Integrative Ayurvedic and Biomedical Management of Polycystic
Ovary Syndrome: A Longitudinal N-of-1 Observational Study with
Clinical and Reproductive Outcomes
Dr. Sachin Jadhav¹*, Dr. Aditi Sirsat²
1Associate Professor, Department of Rachana Sharir, P.V. Belhekar Ayurved Medical College,
Bhanshivare, Newasa, Ahmednagar, Maharashtra, India.
2M.S. Scholar, Department of Stri Rog evum Prasuti Tantra, Pravara Medical Trust’s Ayurved
Mahavidyalaya, Shevgaon, Maharashtra, India.
*Corresponding Author
Received: 21 November 2025; Accepted: 28 November 2025; Published: 05 December 2025
ABSTRACT
background: Polycystic Ovary Syndrome (PCOS) is a chronic endocrine–metabolic disorder marked by
hyperandrogenism, anovulation, and insulin resistance. Integrative approaches combining classical Ayurveda
with modern biomedical therapy are frequently used in India, yet systematically documented real-world
outcomes remain scarce.
Objective: To document longitudinal menstrual, metabolic, and reproductive outcomes in a woman with
PCOS following an integrative Ayurvedic–biomedical therapeutic regimen.
Methods: An N-of-1, eight-month prospective observational study was conducted on a 25-year-old woman
with ultrasound-confirmed PCOS. Therapy included metformin and myo-inositol along with classical
Ayurvedic formulations targeting Kapha–Vata Dushti, Agnimandya, and Srotorodha. Outcomes included
menstrual cyclicity, ultrasound-based ovulation tracking, serial haemoglobin trends, symptomatic changes, and
conception status. All biomedical safety parameters (LFT, KFT) were monitored.
Results: Menstrual cycles gradually normalized (from >45 days to 28–32 days). Ovulation was confirmed by
follicular ultrasound. Haemoglobin increased from 7.3 g/dL to 10.2 g/dL over the observation period. A
spontaneous conception occurred in January 2025. Safety parameters remained within normal limits. Causality
cannot be inferred due to concurrent biomedical therapy and absence of hormonal markers.
Conclusion: Integrative care in this single-subject study was associated with improved cycle regularity,
ovulatory function, hematological restoration, and conception. Controlled trials with standardized protocols are
required to evaluate efficacy and mechanisms.
Keywords: PCOS, Integrative Medicine, Ayurveda, Ovulation, Infertility, Hemoglobin, N-of-1 Study
INTRODUCTION
Polycystic Ovary Syndrome (PCOS) is among the most common endocrine disorders in women of
reproductive age, with a prevalence between 8–13% globally (Teede et al., 2018). Its pathophysiology includes
hyperandrogenism, chronic anovulation, insulin resistance, and systemic inflammation (Azziz et al., 2016;
Barber et al., 2020). Standard biomedical treatment focuses on metabolic correction and induction of
ovulation; however, long-term outcomes remain variable, and many women seek complementary medical
approaches.
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