
INTERNATIONAL JOURNAL OF RESEARCH AND SCIENTIFIC INNOVATION (IJRSI)
ISSN No. 2321-2705 | DOI: 10.51244/IJRSI |Volume XII Issue VIII August 2025
www.rsisinternational.org
Conceptual Clarification
Lifecycle of the Hepatitis B Virus
The Hepatitis B virus has a complex life cycle. The virus enters the liver cell and is transported into the nucleus
of the liver cell. Once inside the nucleus, the viral DNA is transformed into the covalently closed circular DNA
(cccDNA) which serves as a template for viral replication (creation of new Hepatitis B virus). New HBV is
packaged and leaves the liver cell, with the stable viral cccDNA remaining in the nucleus where it can integrate
into the DNA of the host liver cell, as well as continue to create new Hepatitis B virus. Although the life cycle
is not completely understood, parts of this replicative process are error prone, which accounts for different
genotypes or genetic codes of the Hepatitis B virus ( 4).
Complications of Hepatitis B
Chronic hepatitis B can lead to cirrhosis, liver cancer, liver failure and premature death, and the most common
route of hepatitis B transmission globally is perinatal transmission which occurs during the labor and delivery
process. Unvaccinated infants can also become infected shortly after birth or through horizontal transmission in
early childhood from infected blood. Such perinatal infections lead to a high rate of chronicity.{5} The risk of
developing chronic hepatitis B increases to 90% of those infected as neonates and 30% to 50 % among children
infected between one and five years old and 5% to 10% among those infected as adults. The prevalence of
HBsAg among children aged five years is a proxy for new hepatitis B infections from vertical and/or early
horizontal transmission {5, 6}.
WHO’s global health sector strategy impact target for eliminating Viral hepatitis includes a HBsAg prevalence
target for children of ≤ 1% by 2020 and ≥ 0.1 % by 2030. {6}. Considerable progress has been made towards
eliminating the perinatal transmission of HBV and reducing new infections among children through universal
infant HBV immunization, including a timely hepatitis B birth dose. Following birth dose, it is recommended
that universal infant immunization with at least three of the hepatitis B vaccine (HepB3), each separated by least
four weeks commonly referred to as the pentavalent vaccination series. {7}. The first dose of hepatitis B vaccine
should be administered to all newborns as soon as possible after birth, preferably within 24 hours. .If the birth
dose is administered as soon as possible following delivery (within 24 hours) in addition to the pentavalent
vaccination, the infant has a greater than 90% chance of a hepatitis B free future. {8}
Nigeria is among the countries with a hepatitis B virus, prevalence of 11%. {8} Knowledge of viral hepatitis is
relatively low among Nigerians despite being a leading infectious cause of much death each year. {8,9} It is
estimated that over 20 million Nigerians living with viral hepatitis B are undiagnosed, increasing the likelihood
of future transmission to others and placing them at greater risk for severe, even fatal health complications such
as liver cirrhosis and liver cancer (hepatocellular carcinoma). {10}. Hepatitis B Vaccination at birth is critical
to protecting all babies from hepatitis B and liver disease, as newborns exposed to hepatitis B virus are at a high
risk of developing chronic hepatitis B, which can lead to serious liver disease in adulthood.
In Nigeria hepatitis B birth dose has been offered since 2004, however implementation and uptake has been
variable with researchers identifying barriers to timely administration of birth dose including poor knowledge
among health care workers or common misconceptions about administration. Hepatocellular carcinoma (HCC)
is a disease of public health concern in Nigeria, with chronic hepatitis B infections contributing most to the
disease burden. Despite the increasing incidence of HCC, surveillance practices for early diagnosis and possible
cure are not deeply rooted in the country. (11)
According to FO Baba, in Nigeria, only 33% received timely birth dose which is key to preventing MTCT of
HBV. The availability of daily child vaccination services seems to be an obvious requirement for improving
access to the birth dose of HBV vaccine. {15,16} Where is not possible, there should be rapid linkage to the
nearest facility where HBV vaccination is immediately available.
Key facilitators across multiple zones in Nigeria are health literacy, maternal education, and community leader
influence. However, unique regional differences were existed in Nigeria, where North-West zone perceived
vaccine benefits, fear of non-immunization consequences, urban residence, health literacy, and antenatal care