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INTERNATIONAL JOURNAL OF RESEARCH AND SCIENTIFIC INNOVATION (IJRSI)
ISSN No. 2321-2705 | DOI: 10.51244/IJRSI |Volume XII Issue IX September 2025
Uncommon Observation of a Trilobed Left Lung: A Cadaveric Case
Report on Pulmonary Anatomical Variation and Its Embryological,
And Clinical Perspectives
Promise Nwachinemerem Okpechi¹, Nkiruka Lilian Okwuanga²
*
, Michael Obinna Onyewuchi³,
Augustine Alobu Ekoh⁴, Onyinyechi Queen Promise⁵
Department of Anatomy, Nnamdi Azikiwe University, Nnewi Campus, Anambra. Nigeria
*
Corresponding Authors
DOI:
https://doi.org/10.51244/IJRSI.2025.120800366
Received: 06 September 2025; Accepted: 12 September 2025; Published: 15 October 2025
ABSTRACT
We present a rare case of a trilobed left lung, where the left lung possesses three distinct lobes separated by both
horizontal and oblique fissures, mirroring the typical structure of the right lung. This anatomical variation was
discovered during a routine cadaveric dissection at Nnamdi Azikiwe University. The study aims to document
and describe this variation, compare it with classical lung anatomy, explore potential embryological causes, and
highlight its clinical relevance. The discovery of this variation has significant implications for clinical practice,
particularly in radiological diagnosis, thoracic surgery, and pulmonology. Recognizing such variations is crucial
to avoid diagnostic errors, surgical complications, or misinterpretation in imaging. This case reinforces the
importance of cadaveric dissection in anatomical education and highlights the need for region-specific
anatomical documentation.
Keywords: Anatomical variation, Left lung, Trilobed lung, Cadaveric dissection, Clinical implications.
INTRODUCTION
Background of the Study
Human anatomy has long been established as a foundational pillar of medical science, yet it is also a field
enriched by continual discoveries of anatomical variations. Traditionally, the human lungs are asymmetrical: the
right lung comprises three lobes (superior, middle, and inferior), separated by the horizontal and oblique fissures,
whereas the left lung typically has only two lobes (superior and inferior) separated by a single oblique fissure,
accommodating the space taken by the heart (Drake et al, 2020).
However, during a routine cadaveric dissection in a medical anatomy lab, a rare and unusual finding was
encountered: the left lung of the subject cadaver possessed three distinct lobes, clearly demarcated by both a
horizontal and an oblique fissure, mirroring the typical structure of the right lung. This anomaly challenges the
conventional understanding of pulmonary anatomy and demands deeper anatomical, embryological, and clinical
evaluation.
Statement of the Problem
Despite numerous documented variations in human organs, bilateral trilobed lungs remain extremely rare, with
only a few mentions in anatomical literature. The clinical implications of such a variation - especially in thoracic
surgery, radiological imaging, and pathology - highlight the importance of accurate anatomical knowledge.
Failure to recognize such variants can lead to diagnostic errors, surgical complications, or misinterpretation in
imaging.
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Objectives of the Study
1. To document and describe an anatomical variation in the left lung having three lobes.
2. To compare the observed anatomical variant with classical lung anatomy.
3. To explore potential embryological causes for the lobation difference.
4. To highlight the clinical relevance of anatomical variations in pulmonary anatomy.
Significance of the Study
This study contributes to the growing body of literature on anatomical variability, particularly in thoracic
anatomy. It serves as a teaching tool for medical educators and students and provides a reference point for
clinicians, radiologists, and surgeons. Moreover, it underscores the importance of cadaveric dissection as a
critical method for discovering and validating anatomical diversity.
Research Questions
1. How does the observed left lung structure differ from classical descriptions?
2. What embryological factors could explain such an anomaly?
3. What are the possible clinical implications of this variation?
Scope and Limitation of the Study
The study is limited to a single cadaveric case observed in a dissection lab. While it may not provide a statistically
significant sample size, it raises important questions for future anatomical and embryological research.
MATERIALS AND METHODS
Dissection and Documentation
A formalin-embalmed adult male cadaver was dissected at the Gross Laboratory Department of Anatomy,
Nnamdi Azikiwe University, following standard protocols (Carmine & Smith, 2019). The thoracic cavity was
opened, and the lobar and fissural anatomy of both lungs was examined. The anomalous left lung structure was
photographed and compared with standard anatomical references.
Materials Used
1. Preserved adult human cadaver (formalin-fixed, male adult, approximate age unknown)
2. Dissection instruments (scalpels, dissecting scissors, forceps, bone cutters, ribs spreader)
3. Personal protective equipment (PPE)
4. Photography equipment (digital camera or smartphone with high-resolution imaging)
5. Dissection table with drainage
6. Measurement tools (ruler or measuring tape, Vernier caliper for precise measurements)
7. Notebook and pen for in-situ notes and diagrams
8. Anatomy textbooks and atlases for real-time comparison and referencing
Procedure
The thoracic cavity was carefully opened, and observations were made regarding the number of lobes and
fissures in both lungs. The left lung was found to have three clearly demarcated lobes, separated by a horizontal
and an oblique fissure. Observations were compared with classical texts and documented photographically. The
bronchial tree of the left lung was examined to assess corresponding bronchial division.
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Photographed (Promise Onyinyechi Queen)
Fig. 1. Thoracic cavity carefully opened during routine cadaveric dissection.
The lungs were exposed, and observations were made regarding the number of lobes and fissures.
The left lung was found to have three clearly demarcated lobes, separated by a horizontal and an oblique fissure.
RESULTS
Observational Results
During routine anatomical dissection of a male adult cadaver in the Gross Anatomy Laboratory at Nnamdi
Azikiwe University, an anatomical variation in the lobation of the left lung was observed.
Left Lung
External Features of the: The left lung exhibited three well-defined lobes, separated by two fissures:
Superior Lobe
Located at the apex of the lung and anteriorly.
Separated from the middle lobe by a clearly demarcated horizontal fissure.
Middle Lobe
Situated between the superior and inferior lobes.
This lobe is not normally present in the left lung.
Bounded superiorly by the horizontal fissure and inferiorly by an oblique fissure.
Inferior Lobe
Occupied the posteroinferior portion of the lung.
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Extended anteriorly beneath the middle lobe, similar to the normal anatomical inferior lobe.
Fissures
Horizontal Fissure: Extended horizontally from the anterior border of the lung, creating a separation
between the superior and middle lobes.
Oblique Fissure: Extended from the posterior surface obliquely downward and forward to separate the
middle from the inferior lobe.
Right Lung
The right lung of the same cadaver was also examined and found to have the normal three-lobed structure
separated by a horizontal and an oblique fissure.
Photographic Documentation
High-resolution images were taken from multiple angles showing:
The complete left lung with three distinct lobes.
Clear demarcation of the two fissures.
A side-by-side comparison with the right lung.
Comparison with Anatomical Texts
Reference to standard anatomical sources (e.g., Gray’s Anatomy, Moore’s Clinically Oriented Anatomy)
confirmed that the typical human left lung contains only two lobes and one oblique fissure.
No congenital malformation or external pathological evidence was noted in the cadaver.
This observation represents a rare anatomical variation not commonly documented in literature and raises
considerations for clinical imaging, thoracic surgery, and pulmonary diagnostics.
Fig. 2. The left lung presented with three lobes:
A horizontal fissure separating the superior and middle lobes.An oblique fissure separating the middle and
inferior lobes.
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INTERNATIONAL JOURNAL OF RESEARCH AND SCIENTIFIC INNOVATION (IJRSI)
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Fig 3: Anatomical illustration of a trilobed left lung,
Demonstrating a rare variation in lung morphology. This description provides a clear and concise overview of
the diagram, highlighting the key features of the trilobed left lung © Promise N. Opkechi
Fig. 4. This left lung mirrored the structure of the right lung.
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Fig 5: Anatomical illustration of the right lung,demonstrating typical trilobed morphology.
This description highlights the standard anatomy of the right lung,Providing a comparison to the rare trilobed
left lung variation © Promise N. Okpechi
Fig.6: The right lung of the same cadaver with the normal three-lobed structure separated by a horizontal and an
oblique fissure.
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Fig 7: Anatomical illustration of a trilobed left lung,Demonstrating a rare variation in lung morphology.
This description provides a clear and concise overview of the diagram,Highlighting the key features of the
trilobed left lung © Promise N. Opkechi
Fig. 8. The left lung presented with three lobes:
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A horizontal fissure separating the superior and middle lobes.An oblique fissure separating the middle and
inferior lobes.
Fig.9. The left lung presented with three lobes:
A horizontal fissure separating the superior and middle lobes. An oblique fissure separating the middle and
inferior lobes.
DISCUSSION
The discovery of a trilobed left lung separated by a horizontal and an oblique fissure in an adult Nigerian cadaver
represents a rare but clinically significant anatomical variation. This anomaly deviates from the traditional
description of the left lung having two lobes and has important implications for clinical practice.
Clinical Implications
Recognizing this variation is crucial for:
1. Radiologists: Misinterpretation of additional fissures or lobes as pathological findings can lead to
diagnostic errors. For instance, a trilobed left lung may be mistaken for atelectasis or scarring, resulting
in unnecessary interventions.
2. Thoracic Surgeons: Precise anatomical knowledge is essential for procedures like lobectomy,
segmentectomy, or lung transplantation. Failure to recognize atypical lobation may lead to surgical
complications, such as incomplete resection or damage to adjacent structures.
3. Anesthetists and Pulmonologists: Accurate understanding of lung anatomy is vital for bronchoscopy
and segmental lung ventilation. Misinterpretation of anatomical variations can lead to inadequate
ventilation or complications during procedures.
Impact on Clinical Decision-Making
This anatomical variation highlights the importance of considering individual differences in lung anatomy when
making clinical decisions. For example:
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Preoperative Planning: Thoracic surgeons should be aware of potential anatomical variations when
planning lobectomies or other thoracic procedures.
Radiological Interpretation: Radiologists should consider the possibility of anatomical variations when
interpreting imaging studies, particularly in patients with atypical lung anatomy.
The identification of a trilobed left lung in a routine cadaveric dissection emphasizes the importance of
anatomical awareness and documentation in clinical practice. By recognizing and understanding anatomical
variations, healthcare professionals can provide more accurate diagnoses and effective treatment, ultimately
improving patient outcomes.
Embryological Basis
The development of the lungs begins around the 4th week of gestation, with branching morphogenesis shaping
the bronchial tree and lobation. During this process, the embryonic lung undergoes a series of complex cellular
and molecular interactions that ultimately give rise to the mature lung structure.
Branching Morphogenesis
Branching morphogenesis is a critical process in lung development, where the bronchial buds undergo a series
of branching events to form the bronchial tree. This process is regulated by a complex interplay of genetic and
environmental factors, including:
Fibroblast growth factors (FGFs): FGFs play a crucial role in regulating branching morphogenesis,
promoting the growth and differentiation of bronchial epithelial cells.
Sonic hedgehog (SHH) signaling: SHH signaling is essential for the proper formation of the bronchial
tree, regulating the expression of target genes involved in lung development.
Lobation and Fissure Formation
The formation of lobes and fissures in the lung is a complex process that involves the coordinated action of
multiple cellular and molecular mechanisms. Variations in fissure formation, such as the presence of a trilobed
left lung, can result from incomplete or excessive branching of the bronchial buds during embryogenesis.
Aberrant division of secondary bronchial buds: A trilobed left lung may be explained by aberrant division of
the secondary bronchial buds during embryogenesis, resulting in an additional lobe and fissure.
Implications for Anatomical Variation
Understanding the embryological basis of lung development provides valuable insights into the origins of
anatomical variations, such as the trilobed left lung. By recognizing the complex cellular and molecular
mechanisms involved in lung development, clinicians can better appreciate the importance of anatomical
awareness and documentation in clinical practice.
CONCLUSION
The identification of a trilobed left lung in a routine cadaveric dissection highlights the presence of rare
anatomical variations in pulmonary structure that deviate from classical descriptions. This case reinforces the
educational value of cadaveric dissection and underscores the importance of anatomical awareness in clinical
practice. To further investigate similar anomalies, future research could focus on:
1. Radiological studies: Utilizing imaging techniques like CT scans or MRI to identify and analyze similar
variations in living patients.
2. Comparative anatomical studies: Examining the prevalence of such variations across different
populations to better understand their distribution and significance.
3. Embryological studies: Investigating the developmental mechanisms underlying such variations to gain
insights into their etiology.
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By exploring these areas, researchers can deepen our understanding of anatomical variations and their
implications for clinical practice, ultimately improving patient outcomes.
Finally, this case reinforces the educational value of cadaveric dissection as a tool not only for teaching standard
anatomy but also for revealing deviations that may shape clinical understanding and improve patient outcomes.
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