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International Journal of Research and Innovation in Applied Science (IJRIAS) | Volume VII, Issue V, May 2022 | ISSN 2454–6194

Synthesis of Acetyl Resorcinol and Investigation of the Anti Microbial Potentials of Some of its Metal Complexes.

*1Okolo Azubuike Jeremiah, 1Ezenweke Linus Obi, 1Emmanuel Ifeanyi V., 2Osuagwu Collins C, 1Usiakpebru Augustine.
1Department of Pure and Industrial Chemistry, Physical Sciences
Chukwuemeka Odumegwu Ojukwu University Uli,Anambra State
2Department of Chemical Engineering,Imo State Polytechnic,Umuagwo Ohaji.
*Corresponding Author’s

IJRISS Call for paper

Abstract: The chemical synthesis of acetyl resorcinol with glacial acetic acid and resorcinol in presence of zinc chloride as catalyst to obtain acetyl resorcinol was the adopted procedure. The resulting acetyl resorcinol are complexed with the following metals Cr3+, Mn2+, Fe2+ and Co2+ ions. The acetyl resorcinol and its complexes were characterized using IR Spectrometry, Gas Chromatography/ Mass Spectrometry (GC/MS) as well as melting point. The IR Spectrum revealed the functional groups present. The IR absorption shows characteristic behaviour in the sense that, OH group found in 4 – Acetyl resorcinol in the region v(OH):3,303.35cm-1 was absent in the complexes due to deprotonation and co- ordination between metal ion and oxygen of phenol. The type of ligands involved were bidentate and polydentate ligands. The GC/MS studies showed the molecular weight (mass) of the complexes formed. The Mass Spectroscopy of all the compounds show molecular ion peaks indicating molecular weight of the various compounds hence showing that chelation has taken place. Interestingly, all the synthesized compounds were obtained in good yield (74.20% – 90.10%) The antibacterial of the acetyl resorcinol and its metal complexes were screened against Salmonella enteric, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa. It was observed that the growth of micro-organisms were inhibited in acetyl resorcinol, Co complex, Mn Complex. The Fe Complex inhibited the growth of Staphylococcus aureus but could not inhibit others while Cr Complex inhibited the growth of Escherichia coli but could not stop others. This study shows that chemical synthesis and complexation have taken place and the knowledge gained will help to advance the course of bioinorganic and inorganic chemistry.

Keywords: Acetyl resorcinol, Antibacterial, Infrared spectrometry, Spectrum, Metal complexes

I.INTRODUCTION

Over the past few decades, the bacterial resistance to antibiotic has become one of the most important problems of infections treatment. Although there are antimicrobial agents having different structures and mechanism which are frequently used in the treatment of microbial infections even then these agents are associated with resistance. It is necessary to synthesize new classes of antimicrobial compounds possessing different mechanism or