Synthesis of (6E)-1-(1-Benzyl-3-Methyl-1H -Pyrazole-5 (4H) Ylidene) Hydrazine Derivatives

International Journal of Research and Scientific Innovation (IJRSI) | Volume V, Issue II, February 2018 | ISSN 2321–2705

“Synthesis of (6E)-1-(1-Benzyl-3-Methyl-1H -Pyrazole-5 (4H) Ylidene) Hydrazine Derivatives”

J P Paul

 Asst. Prof., Department of Chemistry, Ganapathy Engineering College ,Warangal (dist), Telangana, India

Abstract: Heterocyclic bearing Nitrogen and Sulphur atoms constitute the core structure of a number of biologically interesting compounds. pyrazole derivatives are well established in the literature as important biologically active heterocyclic compounds[7] these derivatives are the subject of many research studies due to their wide spread potential biological activities. A number of pyrozole-Hydrazine derivatives are used for the treatment of chronic inflammatory diseases including rheumatoid arthritis and multiple sclerosis.
Keywords: Pyrazoles; pyrazolone; methyl; Hydrazene; ylidene

I. INTRODUCTION

Pyrazoles are the present target of numerous methods, because of their commonness in temporary or moveable flatform in drug discovery programs and in synthesis of biologically active compounds and their reactions in different chemical species This pyrazole ring is the core in various leading drugs such as Viagra, celebrex etc. Pyrazoles are the building blocks for various research programs in pharmaceutical and agricultural fields Alfa Aesar is the source of various pyrazoles derivatives Already many of the pyrazoles derivatives are clearly notified in various literatures, here are just a few examples of their use. Numerous patents describe the use of the 3-aminopyrazole analogue (H30935) as building block to more complex moieties, such as potential drug candidates. 5-Aminopyrazoles such as H32831 have been used in heterocyclizations involving Narylmaleimides or ethyl2-thien-3-yl-3-hydroxypropenoate. Studies involving H32918 as a building block showed that 3-aminopyrazole derivatives can be selected based MK2-inhibitors. Suzuki coupling of a 7-bromo-1,4-benzoxazine derivative with pyrazole boronate esters (such as H32930, H53139 and L19654) lead to a series of pharmacological active molecules, as potential PI3 kinase inhibitors for the treatment of chronic inflammatory diseases including multiple sclerosis and rheumatoid arthritis.

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