Olusegun D. Oshibanjo, Philips M. Goholshak, Olabisi Akinfolarin, Moses A. Akwashik, Opeyemi Adediran, Idowu Adesope and Lawrence Abegunde – December 2018 Page No.: 01-04
Objective: This study was carried out to evaluate the reproductive performance of rabbits fed Moringa oleifera leaves meal and Moringa oleifera twig meal at 0% 5% and 10% leaves meal (MLM) and 10% twigs meal (MTM). Method: Twenty Female grower rabbits of mixed breed with mean Initial weight of 2323.25 +33.12 and five New Zealand White buck. The animals were randomly allocated in completely randomized design. The data collected includes feed intake, conception rate, litter size, litter weight, weaning weight, and average daily weight gain and litter survival rate. Data were analysed using descriptive statistic and ANOVA at α0.05. Result and discussion: The results obtained reveals that feed intake, litter size and average daily weight gained were not significantly different. However conception rate was significantly (P> 0.05) affected. The litter weight after birth was significantly higher in rabbits fed 10% MLM with least litter weight in rabbits fed no MLM/MTM. The weaning weight was higher in 10% MTM while 5% MLM had the least value. The survival rate was significantly higher in rabbits fed 10% MLM with least survival rate recorded for rabbits fed no MLM/MTM. In conclusion, Moringa oleifera leaves/twigs meals at 10% are excellent feed resources for breeding rabbit.
- Page(s): 01-04
- Date of Publication: 19 December 2018
- Olusegun D. Oshibanjo
Department of Animal Production, University of Jos, Jos Plateau state, Nigeria - Philips M. Goholshak
National Veterinary Research Institute (NVRI), Rabbitary Unit, Vom Jos Plateau state, Nigeria - Olabisi Akinfolarin
Nigerian Institute of Animal Science, Abuja, Nigeria - Moses A. Akwashik
Department of Animal Science, Nasarawa State University, Keffi, Nigeria - Opeyemi Adediran
Department of Animal Science, University of Ibadan, Ibadan Oyo state, Nigeria - Idowu Adesope
Department of Animal Science, University of Ibadan, Ibadan Oyo state, Nigeria - Lawrence Abegunde
Department of Animal Science, University of Ibadan, Ibadan Oyo state, Nigeria
References
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Olusegun D. Oshibanjo, Philips M. Goholshak, Olabisi Akinfolarin, Moses A. Akwashik, Opeyemi Adediran, Idowu Adesope and Lawrence Abegunde “Evaluation of Reproductive Performance of Rabbits Fed Graded Levels of Moringa oleifera Leaves and Twigs Meals” International Journal of Research and Innovation in Applied Science -IJRIAS vol.3 issue 12 December 2018, pp.01-04 URL: https://www.rsisinternational.org/journals/ijrias/DigitalLibrary/Vol.3&Issue12/01-04.pdf
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I.Ponnilavarasan, Mansoor.K.P, K.K.Sivakumar – December 2018 Page No.: 05-10
A simple, fast, precise, selective and accurate RP-HPLC method was developed and validated for the simultaneous determination of Minoxidil and Finasteride from bulk and liquid formulations in the presence of soy lecithin excipient. Chromatographic separation was achieved isocratically on a Phenomenex C18 column (250×4.6 mm, 5 µ particle size) using a mobile phase, Phosphate buffer: acetonitrile: methanol (50:50 v/v) (adjusted to pH 5.8 with NaOH) in the ratio of 30:70. The flow rate was 1.2 ml/min and effluent was detected at 211nm. The retention time of Minoxidil and Finasteride were 3.16, and 8.23 min respectively. Linearity was observed in the concentration range of 50 to 250 μg/ml, 1 to 5 μg/ml for Minoxidil and finasteride with correlation coefficient 0.999 for both the drugs. Percent recoveries obtained for both the drugs were 99.275-99.72 and 98.54-99.3% w/w. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness. The method developed can be used for the routine analysis of Minoxidil and Finasteride in combined dosage form.
- Page(s): 05-10
- Date of Publication: 19 December 2018
- I.Ponnilavarasan
KMCH College of Pharmacy, Kovai Estate, Kalapatty Road, Coimbatore, Tamil Nadu India - Mansoor.K.P
KMCH College of Pharmacy, Kovai Estate, Kalapatty Road, Coimbatore, Tamil Nadu India. - K.K.Sivakumar
KMCH College of Pharmacy, Kovai Estate, Kalapatty Road, Coimbatore, Tamil Nadu India.
References
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[2]. Hemanth K Gaidhane, Jagdish P Bidada, Akshay S Bhusari , Manjusha S Navkhare, Ganesh P Diwanka, Ashish H Tiwari. Development and Validation of Stability Indicating HPLC Method for the estimation of Minoxidil and related substance in topical formulation, Journal of Pharmacy Research, 2011: 4(12), Pg no: 4481-4484.
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[8]. Manish Kumar Thimmaraju, Venkat Rao, Srikanth Gurrala, Jayapal Reddy. UV Spectrophotometric Method for Simultaneous Determination of Finasteride and Tamsulosin in combined dosage form, International Journal of Pharmacy and Biological Sciences, 2011: 1(3), Pg no: 303-310
[9]. Basavaiah.K, Somashekar.B.C, Determination of Finasteride in Tablets by High Performance Liquid Chromatography, E-Journal of Chemistry, 2006: 4, (1), Pg no: 109-116
[10]. Dipti B. Patel, Natubhai J. Patel. Validated RP-HPLC and TLC methods for simultaneous estimation of tamsulosin hydrochloride and finasteride in combined dosage forms, Acta Pharmaceutica, 2010: 60, Pg no: 197–205
[11]. Srinivas.G, KishoreKumar.K, Yarram Rama Koti Reddy, Mukkanti.K, Gangaram V. Kanumula,Madhavan.P, Validated stability indicating LC method of assay and related substances for Finasteride, Journal of Chemical and Pharmaceutical Research, 2011: 3(6), 987-996.
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[13]. Xiaohong Chen, Erin R. Gardner, Douglas K. Price, and William D. Figg. Development and Validation of an LC–MS Assay for Finasteride and its Application to Prostate Cancer Prevention Trial Sample Analysis, Journal of Chromatographic Science, 2008: 46, 356-361.
[14]. Szabolcs Fekete, Jeno Fekete , Katalin Ganzler.Validated UPLC method for the fast and sensitive determination of steroid residues in support of cleaning validation in formulation area, Journal of Pharmaceutical and Biomedical Analysis 49 ,2009, 833–838.
[15]. Phapale PB, Lee HW, Lim MS, Kim EH, Kim SD, Park J, Lee M, Hwang SK, Yoon YR. Rapid determination of finasteride in human plasma by UPLC-MS/MS and its application to clinical pharmacokinetic study, Journal of Chromatography. B. Analytical Technologies in the Biomedical and Life Sciences, 2010 Jun 15; 878(20):1718-23.
I.Ponnilavarasan, Mansoor.K.P, K.K.Sivakumar”Simultaneous Estimation of Minoxidil and Finasteride by RP-HPLC in Presence of Soy Lecithin Excipient in Lotion Dosage Form” International Journal of Research and Innovation in Applied Science -IJRIAS vol.3 issue 12 December 2018, pp.05-10 URL: https://www.rsisinternational.org/journals/ijrias/DigitalLibrary/Vol.3&Issue12/05-10.pdf
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Mustapha A. Tijjani, Fanna I. Abdulrahman, Sherriff Adam, Usman B. Shamaki December 2018 Page No.: 11-17
Citrus aurantifolia Linnhas many medicinal and pharmacological significance. This work aimed at evaluating the phytochemical constituents, acute toxicity and the anti-nociceptive activity of the methanol crude stem bark extract of Citrus aurantifolia. Presence of some bioactive metabolites: cardiac-glycosides, terpeniods, flavonoids, tannins and phlobatannins were found in crude methanol extract. Acute toxicity ( LD50) of the methanol crude extract was determined and it was observed that there was no mortality at 5000mg/kg b.d.wt. Hence, the extract was found to be non toxic. In acetic-acid induced test the methanol stem bark extract demonstrated significant antinociceptive activities (P≤0.05), the percentage inhibitions of the treatment groups were 48.3%, 52.6% and 57.9%.Pentozocine (20 mg/kg), a standard drug gave the percentage inhibition of 67.8%. The extract on tail immersion test appeared to increase the mean reaction time at (30 min.) were found to be 5.00±0.00s, 5.80±0.37s, 6.00±0.32s and 7.00±0.32s respectively and at (120 min.), were observed to be 4.40±0.25s, 5.20±0.20s, 5.40±0.25s and 5.80±0.20s. Pentozocine gave mean reaction time of 9.00±0.32s, 8.00±0.32s, 7.60±0.68s and 6.20±0.20s respectively at various post treatment time intervals.The percentage inhibitions of methanol extract on tail immersion test at dose of 400mg/kg was 20%,at 30min, at 60min, was 71.4%, at 90min. was 32% while at 120min. was 22.7% and finally, for the 600mg/kg body weight were 40%, 80.9%, 36% and 31.8 respectively. The pentozocine gave percentage inhibitions at 30, 60, 90, 120 min were 80%, 90%, 52% and 40.9% for various doses at post treatment time were found to be higher than that of the methanolextract. Moreover the extract appeared to induced an increase in pain threshold at (P˂0.05) to Eddy’s hot plate. The maximum dose of 600mg/kg, the percentage increase in pain threshold of 82.4% respectively. Pentozocine (20 mg/kg) showed mean reaction time of 6.60±0.24s and percentage increase in pain threshold 94.1%. The activity of the pentozocine was found to be significantly higher compared to the extract although, they were all significant at (P≤ 0.05) across the column. Thus, the usage of the plant in treatment of analgesic condition by local people could be justified.
- Page(s): 11-17
- Date of Publication: 20 December 2018
- Mustapha A. Tijjani
Department of Chemistry, Faculty of Science, University of Maiduguri, P.M.B 1069, Maiduguri, Borno State, Nigeria. - Fanna I. Abdulrahman
Department of Science Laboratory Technology, Ramat Polytechnic Maiduguri, P.M.B. 1070 Maiduguri, Borno State – Nigeria. - Sherriff Adam
Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Maiduguri, Borno State., Nigeria - Usman B. Shamaki
Department of Pharmaceutical Chemisty, Faculty of Pharmacy, University of Maiduguri, Borno State, Nigeria
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Mustapha A. Tijjani, Fanna I. Abdulrahman, Sherriff Adam, Usman B. Shamaki”Phytochemical Screening, Acute Toxicity and Anti-Nociceptive Activity of Methanol Stem Bark Extract of Citrus aurantifolia Linn” International Journal of Research and Innovation in Applied Science -IJRIAS vol.3 issue 12 December 2018, pp.11-17 URL: https://www.rsisinternational.org/journals/ijrias/DigitalLibrary/Vol.3&Issue12/11-17.pdf
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Yogesh Rathod, Durgesh Khairnar, Manoj Deore, Bhaulal Phad, R. J. Nikam – December 2018 Page No.: 18-20
Traction motor system in India works on single phase 25kV traction system. If this single phase traction load is supplied from only one phase then it creates the unbalance effect in three phase system to reduce unbalancing effect, all these phases are tapped from the adjacent substations in sequence. These phases are electrically isolated from each other by means of neutral sections normally provided near the traction substation (TSS) and sectioning post (SP). But at such section post or near neutral section only sign boards are used which give the indication to driver at that time DJ (circuit breaker) should be open, which may not be clearly seen in the foggy, rainy, snowing and polluted environment. Due to ignorance of such sign electrical hazard is possible. Hence our project basically focused on the automatic clearing of such a neutral section using sensor, relay, and use of circuit breaker at the start and end of the neutral section and it’s function is to carry the supply of running phase to neutral section by disconnecting the next phase, without loss (interruption) of the supply from OHE and continuous operation of the all electrical equipment on the train, which is not possible at the present in neutral section.
- Page(s): 18-20
- Date of Publication: 05 January 2019
- Yogesh Rathod
BE Student, Dept. of Electrical Eng., MET BKC IOE, Nashik, Maharashtra, India - Durgesh Khairnar
BE Student, Dept. of Electrical Eng., MET BKC IOE, Nashik, Maharashtra, India - Manoj Deore
BE Student, Dept. of Electrical Eng., MET BKC IOE, Nashik, Maharashtra, India - Bhaulal Phad
BE Student, Dept. of Electrical Eng., MET BKC IOE, Nashik, Maharashtra, India - R. J. Nikam
Assistant Professor, Dept.o f Electrical Eng., MET BKC IOE, Nashik, Maharashtra, India
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[1]. H. Preatap, “Modern electric traction s”, DhanpatRai& Co.
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Yogesh Rathod, Durgesh Khairnar, Manoj Deore, Bhaulal Phad, R. J. Nikam “Automatic Switched Neutral Section in Railway” International Journal of Research and Innovation in Applied Science -IJRIAS vol.3 issue 12 December 2018, pp.18-20 URL: https://www.rsisinternational.org/journals/ijrias/DigitalLibrary/Vol.3&Issue12/18-20.pdf
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James T. Ihum and Fabian Stephen – December 2018 Page No.: 21-28
This paper has investigated the viability of constructing Kashimbilla Multipurpose Dam in Taraba State Nigeria using Cost and Benefit Analysis (CBA) under two different scenarios. It particularly varied interest rate, project costs and benefits. The analysis has demonstrated that Kashimbilla Dam is a worthwhile project. While the result from the computation of the CBA suggests that the project is viable, other social benefits such as improved crop yields resulting from irrigation services, improved water availability, full benefits from flood control (value of human life), increased access to water resources, creation of employment and tourism indicate also that the project is a worthy public undertaking.
- Page(s): 21-28
- Date of Publication: 06 January 2019
- James T. Ihum
Former Postgraduate Student, Department of Economics, LUBS, University of Leeds, UK - Fabian Stephen
Center for Energy, Petroleum and Mineral Law and Policy, School of Social Sciences, University of Dundee, UK
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James T. Ihum and Fabian Stephen “A Cost and Benefit Analysis of Kashimbilla Multipurpose Dam Project in Takum, Taraba State, Nigeria ” International Journal of Research and Innovation in Applied Science -IJRIAS vol.3 issue 12 December 2018, pp.21-28 URL: https://www.rsisinternational.org/journals/ijrias/DigitalLibrary/Vol.3&Issue12/21-28.pdf
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Umar Dan’azumi, A. M. Fulata, Suleiman Ali, Mohammed Audu, M. M. Garandawa – December 2018 Page No.: 29-45
Terminalia catappa is a family of combretaceae which constitutes of many bioactive components. One thousand grammes (1000g) of the leaf of Terminalia catappa was extracted with methanol using cold infusion techniques. Crude extract obtained, which was further partitioned with n-hexane, ethyl acetate, n-butanol and water to give n-hexane portion (1.638% W/W), dark green in colour, oily in texture, ethyl acetate portion (0.075% W/W), black in colour, gummy in texture, n-butanol portion (0.777% W/W), brown in colour, oily in texture and finally aqueous portion (2.997% W/W), dark brown in colour, powdered in texture. Preliminary phytochemical screening of the methanol crude extract and partitioned portions revealed the presence of some secondary metabolites such as cardiac glycoside, flavonoids, saponins, terpenoids, tannins and alkaloid. However, metabolites such as phlabotannins and glycosides were tested negative. The n-butanol portion was subjected to purification using column and thin layer chromatography methods. Fractions were obtained rerun, recombined and pooled based on their retardation factor (Rf). Pure isolate with retardation factor (Rf) 0.4 and melting point 286.00-287.00oC which was subjected to Gas Chromatography Mass Spectrometry (GC-MS) and the result was compared using NIST library of compounds which are of therapeutic values.
- Page(s): 29-45
- Date of Publication: 06 January 2019
- Umar Dan’azumi
Department of Basic Science, College of Agriculture Gujba, P.M.B 1104 Damaturu Yobe State-Nigeria - A. M. Fulata
Department of Remedial Science, Ramat Polytechnic Maiduguri, P.M.B 1070 Maiduguri, Borno State-Nigeria - Suleiman Ali
Department of Basic Science, College of Agriculture Gujba, P.M.B 1104 Damaturu Yobe State-Nigeria - Mohammed Audu
Mai Idris Alooma Polytechnic Geidam, P.M.B 1020 Geidam Yobe State-Nigeria - M. M. Garandawa
Mai Idris Alooma Polytechnic Geidam, P.M.B 1020 Geidam Yobe State-Nigeria
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Umar Dan’azumi, A. M. Fulata, Suleiman Ali, Mohammed Audu, M. M. Garandawa “Preliminary Phytochemical Screening and GC-MS Analysis of the Bioactive Components of the Leaf of Terminalia catappa” International Journal of Research and Innovation in Applied Science -IJRIAS vol.3 issue 12 December 2018, pp.29-45 URL: https://www.rsisinternational.org/journals/ijrias/DigitalLibrary/Vol.3&Issue12/29-45.pdf
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