An Assessment of Hormonal Contraceptives on Plasma Glucose and Lipid Profile of Women Attending Family Planning Clinic at Keffi, Nasarawa State, Nigeria
- August 25, 2019
- Posted by: RSIS
- Category: Biochemistry
International Journal of Research and Scientific Innovation (IJRSI) | Volume VI, Issue VIII, August 2019 | ISSN 2321–2705
Ogechi Juliet Alisigwe
Department of Biochemistry, Imo State University, Owerri, Nigeria
Abstract: This study seeks to determine the influence of the type, duration of contraceptive used and the age of users on Biochemical parameters such as glucose and lipid amongst women in Keffi, Nasarawastate of Nigeria. The study group consisted of 400 women (age range 18-41 years) who were equally distributed into four groups based on contraceptive used (Noristerate =100, Depo-provera=100, Oral pills= 100 and Norplant =100) for a period of two (2) years, while 50 are control groups. Glucose, triglyceride, total cholesterol, LDL-Cholesterol and HDL-Cholesterol were determined using standard colorimetric methods. There were significant increase in the mean value of total cholesterol (4.82±0.46), triglyceride (1.67±0.11), LDL-Cholesterol (2.37±0.23) and glucose (5.21±0.22) in test group when compared with the control groups with total cholesterol (3.34±0.12), triglyceride (0.89±0.04), LDL-cholesterol (1.89±0.05) and glucose (3.94±0.20) (p<0.05). Results also showed monthly significant increase (p>0.05) in the levels of glucose, Total cholesterol, triglyceride and LDL-Cholesterol following administration of Noriesterate, Depo-provera and Oral pill while the level of HDL- Cholesterol significantly decreased (p<0.05) within the duration of contraceptives used when compared with the control group. However, for women taking Norplant, there was monthly significant decrease (p<0.05)in the levels of glucose, Total cholesterol, triglyceride and LDL-Cholesterol while the HDL-Cholesterol levels were significantly increased suggesting that Norplant could be the most preferred hormonal contraceptive to others under this study. The levels of Glucose, Total cholesterol, Triglyceride and LDL-Cholesterol in this study, were significantly (p>0.05) increased as the age range of the users increases from 18-23 to 36-41 indicating that age has a direct influence on contraceptive used. Similarly, there was a significant increase in BMI by 8.6% between women using contraceptives and the non-users. It could be concluded that hormonal contraceptives alter lipid metabolism and induced dyslipidemia.
Keywords: Hormonal, Contraceptives, Plasma, Glucose, Lipid Profile, Family Planning
