Anti-Inflammatory and Antioxidant Activity of the Hydroalcoholic Extract of Cynodon Dactylon L. Pres.
- July 2, 2018
- Posted by: RSIS
- Category: Pharmacy
International Journal of Research and Scientific Innovation (IJRSI) | Volume V, Issue VI, June 2018 | ISSN 2321–2705
Sneha Sahadeo Kirgat, Swati R. Dhande
Bharati Vidyapeeth College of Pharmacy, C.B.D Belapur, Navi-Mumbai, Maharashtra, India
Abstract: The present work was aimed to study the anti-inflammatory activity of Cynodon dactylon L. Pres.; using hydroalchoholic extract of entire plant on rodent models. The experimental paradigm included pulmonary edema in mice and granuloma pouch technique in rats In pulmonary edema model; mice received hydroalcoholic extract of Cynodon dactylon L. Pres. (HECD) 600 mg/kg, p.o. Mice were challenged with intrapleural injection of 0.1 ml of 1 % suspension of carrageenan in saline, one hour after administration of drugs or vehicle, on the right side of the thorax. In Granuloma pouch technique rats received HECD 600 mg/kg, p.o. and after 24 hour were challenged with carrageenan (4 ml of 2% w/ v of carrageenan solution in saline, s.c.). Indomethacin (10 mg/kg) was used as reference standard. The effect of the HECD against pulmonary edema in mice; was found to be significantly (**P<0.01) effective as well as the effect of HECD on the increased protein infiltration induced by carrageenan was found to be significant (**P<0.01).
Key words: Cynodon dactylon, anti-inflammatory activity, Indomethacin, Carrageenan.
I. INTRODUCTION
In ancient Greek and Roman era, inflammation was regarded as a single disease entity and the result of a disturbed state of body fluids. The interesting concept of inflammation was then outlined that inflammation itself should not be considered as a disease, but as a salutary operation consequent either to process of inflammation as a succession of changes occurring in a living tissue when it is injured providing that the injury is not of such a degree of severity so as to at once destroy its structure and vitality. It is defined as a series of responses due to release of endogenous substances following injury by the vascularized tissues of the body. Pain that accompanies inflammation and tissue injury may cause local stimulation of pain fibers and enhanced pain sensitivity. Most currently available and commonly used drugs to treat symptoms of inflammation and most types of arthritis include the group of non steroidal anti-inflammatory drugs (NSAIDs). A major aspect of mechanism of action of the NSAIDs is of both cyclooxygenase isoenzymes, namely cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) activities, and thereby synthesis of prostaglandins and thromboxane. In addition to sharing many therapeutic activities NSAIDs share many unwanted side effects like gastric ulceration, intolerance, inhibition of platelet function, renal damage etc [1].
