Effect of Combined Root Extract of Sphenocentrum Jollyanum and Baphia Nitida on Some Lipid Profile Indices in Male Wistar Albino rats
- April 24, 2019
- Posted by: RSIS
- Category: Biochemistry
International Journal of Research and Scientific Innovation (IJRSI) | Volume VI, Issue IV, April 2019 | ISSN 2321–2705
Wopara, Iheanyichukwu1*, Uwakwe, A. A2, and Wegwu, M. O.3
1,2,3 Department of Biochemistry, Faculty of Science, University of Portharcourt, Nigeria
*Corresponding author
Abstract:-This study is aimed at investigating the effect of combined extract of Sphenocentrum jollyanum and Baphia nitida on some lipid profile indices in male wistar Albino rats. Seventy (70) Male Wistar rats were divided into seven (7) groups with ten (10) rats per group. Group 1(control) were fed normal feed and water, Group 2 were treated with 200mg/kg S.jollyanum ,Group 3 were treated with 200mg/kg B.nitida, Group 4 were treated with 200mg/kg S.Jollyanum+B.nitida, Group 5 were treated with 400mg/kg S.jollyanum +B.nitida, Group 6 were treated with 400mg/kg S.jollyanum and Group 7 were treated with 400mg/kg B.nitida via orogastric feeding for 12 weeks. The result was analyzed using One way ANOVA, followed by post hoc multiple comparisons and level of significant set at p > 0.05. Randox reagent diagnostic kit was used to perform the test. The results of the investigation revealed that there were no significant differences (p>0.05) in the serum cholesterol concentrations between the control rats and the rats treated with different concentrations of Sphenocentrum jollyanum and Baphia natida compared to the control. However, the rats treated with 200 and 400mg/kg bw of diherbal mixture of Sphenocentrum jollyanum and Baphia natida, although the mean differences were not statistically significant (p>0.05). Similarly, there were no significant difference (p>0.05) in the serum levels of triglyceride in the extract fed rats when compared with the control. Though elevated levels were recorded in groups fed with 200 and 400mg/kg b.w of diherbal mixture of S. jollyanum and B. Natida although the mean differences were not significant (p>0.05). The HDL result showed that there were significant difference (p>0.05) in the serum HDL concentrations between the control rats and the rats treated with 200 and 400mg/kg of diherbal mixture of Sphenocentrum jollyanum + Baphia natida compared to the control rats. The change in cholesterol levels may suggest possible effect of high dose and prolonged administration of the extracts which might lead to heart disease.
Keywords: Sphenocentrum jollyanum, Baphia nitida, cholesterol, triglyseride and orogastric
