Formulation and Evaluation of Paliperidone Palmitate Loaded Nanoparticles Using Biodegradable Polymers
- February 11, 2019
- Posted by: RSIS
- Category: Pharmacy
International Journal of Research and Scientific Innovation (IJRSI) | Volume VI, Issue II, February 2019 | ISSN 2321–2705
Sreekanth M.C1, Reshmi K2, K.G Parthiban3, Jerome K George4, Anusha Ajayakumar5
1Assistant Professor, Department of Pharmaceautics, Nehru College of Pharmacy, Pampady, Thrissur-680588, Kerala, India
2Nehru College of Pharmacy, Pampady, Thrissur-680588, India
3Professor and HOD, Department of Pharmaceutics, Nehru College of Pharmacy, Pampady, Thrissur-680588, India
4Assistant Professor, Department of Pharmaceutics, St. Johns College of Pharmaceutical Sciences and Research, Kattappana, Idukki-685508, India
5Assistant Professor, Department of Pharmaceutical Analysis, Nehru College of Pharmacy, Pampady, Thrissur-680588, India
Abstract:-Paliperidone palmitate also known as 9-hydroxyrisperidone, is a dopamine antagonist and 5-HT2A antagonist of the typical antipsychotic class of medications. The present study intends to carry out the formulation and evaluation of Paliperidone palmitate loaded biodegradable nanoparticles. The major goals in designing nanoparticles as a delivery system are to control particle size, surface properties, and release of pharmacologically active agents so as to achieve the site specific action of the drug at the rational rate and dose. Nanoparticles are synthesized by the nano-precipitation method. Nanoparticles of paliperidone palmitate were obtained with high encapsulation efficiency 60-80%. Nanoparticles are generally characterized by their size, morphology, surface charge using the advanced microscopic techniques such as Scanning electron microscopy (SEM). Drug entrapment efficiency was determined by centrifugation. These studies suggest the feasibility of formulating paliperidone palmitate loaded nanoparticles using a biodegradable polymer (Gelatin) for the treatment of psychotic disorders.
Keywords:-Paliperidone palmitate, biodegradable polymers, gelatin, nanoprecipitation.
I. INTRODUCTION [2],[7],[9],[16]
The most emerging branch in pharmaceutical sciences known as “Pharmaceutical nanotechnology” presents new tools, opportunities and scope, which are expected to have significant applications in disease diagnostics and therapeutics. Nanoparticles are defined as particulate dispersions or solid particles with a size in the range of 10-1000nm.
