Hepatoprotective Activity of Carica Papaya and Ficus Bengalensis Latex against Paracetamol Induced Hepatotoxicity in Rats

International Journal of Research and Scientific Innovation (IJRSI) | Volume V, Issue VIII, August 2018 | ISSN 2321–2705

Hepatoprotective Activity of Carica Papaya and Ficus Bengalensis Latex against Paracetamol Induced Hepatotoxicity in Rats

Yogendra Kumar¹, Girendra Gautam², Pushpesh Kumar Mishra³

  Research Scholar, Faculty of Pharmacy, Bhagwant University, Sikar Road, Ajmer, Rajasthan, India

Abstract— Objectives: The aim of the present study was to evaluate the hepatoprotective activity of Carica Papaya latex and Ficus bangelensis latex against Paracetamol induced hepatotoxicity in rats.
Method: Paracetamol (3g/kg.b.w) was used to induced hepatotoxicity in rats. Salymarin (100mg/kg)was used as a standard drug for present study. Silymarin and Carica Papaya Latex at the dose 400mg/kg/b.w. per oral and Ficus bangelenesis latex at dose 300mg/kg/b.w. per oral were given for 10 days followed by single administration of Paracetamol 3mg/Kg b.w. per oral 1hour after Caraca Papaya Latex , Ficus Bengalasis and Silymarin administration for 10 days. On 10 days blood samples were collected from the animals for biochemical analysis and liver were subjected to histopathological examination.
Result and Discussion: The degree of protection was measured by using bio-chemical parameters like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), Bilirubin (BRN), Alkaline phosphate (ALP) and total protein. The decreased levels of SGOT, SGPT, ALP, Bilirubin and increased levels of total protein parameters in treated rats were an indication of the hepatoprotective activity of Carica papaya latex and Ficus bengalenesis latex. Silymarin (100 mg/kg) a well known hepatoprotective drug used for comparision exhibited significant activity (<0.05). Conclusion: The both plants latex were completely prevented the toxic effect of Paracetamol on the above serum parameter. Significant hepatoprotective activity of both plant latex were reported. Carica papaya latex was found to be more protective effect as compare to Ficus bengalenesis latex.

Keywords— Carica Papaya, Ficus Bengalensis, Hepatoprotective, Paracetamol, Silymarin.

I. INTRODUCTION

Liver is a vital organ human body which is maintained the Metabolic reactions in the human body but unnecessary food habits, consumed impure drinks may be bring problems in functioning of the liver consumed more number of drugs can cause damage the liver and Liver Architecture, like junk food intake of alcohols. Damage of liver can elevated levels of serum enzymes like Bilirubin, SGPT and SGOT[1].

Read More