Investigation of Salivary Enzyme Levels in Periodontitis Patient of Bangladeshi Population: A Priliminary Study

International Journal of Research and Scientific Innovation (IJRSI) | Volume VI, Issue VII, July 2019 | ISSN 2321–2705

Investigation of Salivary Enzyme Levels in Periodontitis Patient of Bangladeshi Population: A Priliminary Study

Sharif Neaz¹, Sayeeda Monira Rahman², Fatema Tuz Jhura³

¹Lecturer, Department of Biochemistry & Molecular Biology, Tejgaon College, Dhaka-1215, Bangladesh
²Lecturer, Department of Biochemistry, Habibullah Bahar University College, Shantinagar, Dhaka-1000, Bangladesh
³Medical Officer, Department of Oral and Maxillofacial Surgery, Uttara Executive Centre (National Healthcare Network), Dhaka- 1230, Bangladesh

Abstract: – The aim of the study was to find any association exists between salivary enzyme ALP, ALT, AST and CK level of periodontitis Bangladeshi individuals with their pathological oral condition. In this study levels of ALP, ALT, AST and CK were determined in saliva sample of periodontitis patient. The experimental group contains 50 (fifty) periodontitis patient and 50 (fifty) healthy individuals were served as control. Saliva sample was collected in sample tube and biochemical analysis was done in Biochemistry semi automatic analyzer. Periodontitis was diagnosed by a dental surgeon based on Gingival index (GI), Probing depth (PD) and Clinical attachment loss (CAL). Results were analyzed statistically by one way ANOVA test with SPSS software. Salivary enzyme level of periodontitis patient was compared with the salivary enzyme level of normal control group. ALP, ALT, AST and CK level of periodontitis patients were increased in the saliva than that of control group.

Key words: Alkaline Phosphatase (ALP), Alanine Transaminase (ALT), Aspertate Transaminase (AST), Creatine Kinase (CK), Periodontitis, Gingival Index (GI), Probing Depth (PD), Clinical Attachment Loss (CAL)

I. INTRODUCTION

Periodontal disease is one of the commonest inflammatory diseases which are multi factorial in origin. Periodontitis is an inflammatory disease which affects the periodontium which is the collective form of free and attached Gingiva, Periodontal ligament, Cementum and alveolar bone. The most common form of periodontitis is chronic periodontitis which is irremediable and combined condition that damages tissue through the complex associations between periopathic bacteria and the host immune system (1). Among many diseases that affect teeth, periodontitis is a very common disease that causes the destruction of supporting structures of teeth, progressively results to tooth loss (2). Although periodontitis is an infectious disease of gingival tissue, destruction of alveolar bone is responsible for tooth loss. The commonest cause of alveolar bone damage during periodontitis is due to the progressive inflammation from the marginal gingiva to the underlying periodontal tissues (3).

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