Synthesis, Characterization and In -Vitro Antimicrobial Activities of a Schiff Base Derived From Benzaldehyde with Nitroaniline and Their Cobalt (II) and Nickel (II) Metal Complexes
- December 17, 2020
- Posted by: RSIS Team
- Categories: Applied Science, Chemistry, IJRSI
International Journal of Research and Scientific Innovation (IJRSI) | Volume VII, Issue XII, December 2020 | ISSN 2321–2705
Obadahun.J*, Agho O.B, Dike.R.C, Ojeleye.F.S, Akabuogu.E.P, Omotola.M.B, Jakheng. S.P.E
Nigerian Institute of Leather and Science Technology (NILEST), ZARIA Department of Science Technology, P.M.B
1034 Samaru, Zaria. Kaduna state, Nigeria
ABSTRACT
Schiff base derived from an equimolar amount of benzaldehyde with P-nitroaniline was synthesized by stirring. The Schiff base was subsequently reacted with cobalt(II) chloride hexahydrate and nickel (II) chloride hexahydrade to form the metal complexes. The compounds were characterized using FT-IR, UV-visible, melting point/decomposition and solubility test. The solubility test of the compounds showed that they are soluble in most organic solvents and the melting point of the schiff base ligand was found to be 147.8 oC and the decomposition temperature of the Cobalt(II) and Nickel(II) were found to be 158.8 oC and 157.9 oC for the cobalt(II) and Nickel(II) complexes respectively. The UV and the IR spectroscopy confirmed the formation of complex. The antimicrobial studies of the synthesized ligands and their Cobalt(II) and Nickel(II) metal complexes were carried out in against Candida albican fungal species, Gram positive bacteria Staphylococcusaureus and Gram negative bacteria Eschaerichia coli. The results indicated that the metal complexes were more active than the ligand but less active compared to standard drugs (ciprofloxacin and floconazole).
1.0 INTRODUCTION
Schiff base is a nitrogen analog of an aldehyde or ketone in which the C=O group is replaced by a compound containing C=N-R group ( Maher A.K., and Mohammed R. S.,2015). It is formed by condensation of an aldehyde or ketone with a primary amine (Alka P. and Anil K.,2015) according to the following scheme: Where R, may be an alkyl or an aryl group. Schiff bases that contain aryl substituents are substantially more stable and more readily synthesized, while those which contain alkyl substituents are relatively unstable. Schiff bases of aliphatic aldehydes are relatively unstable and readily polymerizable while those of aromatic aldehydes having effective conjugation are more stable (Nasira N. S., et al 2016). The formation of a Schiff base from an aldehydes or ketones is a reversible reaction and generally takes place under acid or base catalysis, or upon heating (Nasira N. S., et al 2016) .
Schiff bases are also known as anils, azomethines or imines In the polydentate Schiff base ligands( Mohammed A.A., et al, 2011), along with main functional group azomethine, the other donor sites contain various electronegative atoms such as oxygen, nitrogen and sulphur(Thierry Y. F., 2018). Schiff bases can be synthesized using various methods such as microwave irradiation method (Yang & Sun, 2006), green or environmental friendly method and normal conventional method (Zarei & Jarrahpour, 2011). The aim of this research is to synthesize, characterize and carry out antimicrobial activities for a Schiff base derived from P-nitroaniline and benzaldehyde and its Cobalt(II) and Nickel(II) metal complexes.
