The Effects of the Extracts of Ginger and Aloe Vera on Wistar Rats Model of Type 2 Diabetes Induced With Dexamethasone and High Fat Diet
- March 13, 2020
- Posted by: RSIS
- Categories: Biochemistry, IJRSI
International Journal of Research and Scientific Innovation (IJRSI) | Volume VII, Issue II, February 2020 | ISSN 2321–2705
Aleme, B. M., Uwakwe, A.A and Amadi, B. A.
1,2,3Department of Biochemistry University of Port Harcourt. Rivers State Nigeria
Abstract: Africa and Nigeria to be precise is characterized by a rich diversity of ethno-medicinal plants as well as a rich traditional medicine system. An ethno-botanical survey was conducted to collect information about medicinal plants used for the treatment of diabetes especially the type 2 diabetes, ginger and aloe vera were part of the commonly used plant parts in Nigeria. This study assessed insulin resistance in normal and diabetic animal subjects using homeostatic model (HOMAIR). The research compared the effectiveness of natural plants extract (ginger and aloe vera) source with and without two anti-insulin resistant drugs (Glimepiride and Metformin) and one anti-insulin resistant herb (Cinnamon) after inducement of insulin resistance by dexamethasone and high fat diet (25% lard, 7% egg, and 15% sucrose). The study evaluate dyslipidaemia and hyperinsulinaemia in sampled subjects Eighty four wistar albino rats were used in this study, being divided into fourteen groups of six rats each and fed with high fat diet, inducted with dexamethasone, and treated with Glimepiride, Metformin, Cinnamon, Ginger, and Aloe vera in various doses with the exception of the normal and negative controls. Each sample of blood serum and plasma was analyzed using Randox kits to test for various biochemical parameters. Compared with the normal control, the mean values of the parameters were significantly different (p<0.05) from each other with few exceptions. Compared with the animal controls, the results showed a significant difference (p<0.05). Groups fed with high fat diet showed an increase in LDL, CHOL and TG levels where the LDL and CHOL and TG levels of the induced and untreated and even the treated groups were much higher than that of the normal control groups. The groups treated with Glimepiride, Metformin, and Cinnamon showed improvement. The various doses of Ginger, Aloe vera, and their mixture, showed improvement with an increase in the level as the dose increased. Conclusively, the assessment of insulin resistance studied using the models proved that insulin resistance can be managed when appropriate lifestyle is adopted.
Keywords: Ginger, Aloe vera, Type 2 diabetes, Dexamethasone, high fat diet, synergetic, Insulin resistance.
I. INTRODUCTION
Medicinal herbs prepared using various parts of the plantsare being used all over the world as remedy to cure human diseases. It is well known that the medicinal property of plants or plant extracts is due to the phytochemical substances present in them[1].
