Nanoparticle – Based Drug Delivery for Stomach Cancer

Stomach cancer, or gastric cancer, continues to be a major global health challenge, largely because it is often detected late and responds poorly to standard treatments. Traditional therapies like chemotherapy and radiotherapy frequently struggle with issues such as high toxicity, low drug solubility, and the development of multidrug resistance. In recent years, nanoparticle-based drug delivery systems have emerged as a promising way to overcome these barriers. By designing nanoparticles that can carry drugs directly to the tumour, researchers are able to achieve better targeting, controlled drug release, and enhanced drug accumulation at the cancer site through the enhanced permeability and retention (EPR) effect. When nanoparticles are further modified with specific ligands, they can actively recognize tumour markers, improving, treatment precision while reducing harm to healthy tissues. Innovations in polymeric nanoparticles, liposomes, dendrimers, metallic nanoparticles, and nano-micelles have significantly improved drug stability, bioavailability, and overall patient comfort. As this review highlights, the integration of nanotechnology into gastric cancer therapy represents an exciting step toward personalized medicine and may open the door to more effective clinical treatments in the future.

Stomach cancer, gastric cancer, nanoparticle-based drug delivery

1. Zou J., Chen S., Liu W., Wang Y., Zheng D., Sun W., Xu S., Wei W., Wang S. (2025). Nano formulation-based drug delivery systems for the treatment of gastric cancer: recent developments and future prospects. Nanoscale Horizons. https://pubs.rsc.org/en/content/articlelanding/2025/nh/d5nh00344j [Google Scholar] [Crossref]

2. Nanotechnology-based strategies for gastric cancer imaging and treatment. (2021). RSC Advances. https://pubs.rsc.org/en/content/articlehtml/2021/ra/d1ra01947c [Google Scholar] [Crossref]

3. DOI: 10.1039/d5pm00179j Received 7th July 2025, Accepted 12th October 2025 DOI: 10.1039/d5pm00179j Rsc.li/RSCPharma [Google Scholar] [Crossref]

4. Zhang Y., et al. (2022). Applications of nanomaterials for gastrointestinal tumors: A review. Frontiers in Medical Technology, 4, 997123. https://www.frontiersin.org/journals/medicaltechnology/articles/10.3389/fmedt.2022.997123/full [Google Scholar] [Crossref]

5. Liu H., et al. (2023). Metal nanoparticles as a potential technique for the diagnosis and treatment of gastrointestinal cancer: a comprehensive review. Cancer Cell International, 23, 3115. https://cancerci.biomedcentral.com/articles/10.1186/s12935-023-03115-1 [Google Scholar] [Crossref]

6. .Zou J., Chen S., Liu W., Wang Y., Zheng D., Sun W., Xu S., Wei W., Wang S. (2025). Nanoformulation-based drug delivery systems for the treatment of gastric cancer: recent developments and future prospects. Nanoscale Horizons. https://pubs.rsc.org/en/content/articlelanding/2025/nh/d5nh00344j [Google Scholar] [Crossref]

7. Zhang Y., et al. (2022). Applications of nanomaterials for gastrointestinal tumours: A review. Frontiers in Medical Technology, 4, 997123. https://www.frontiersin.org/journals/medicaltechnology/articles/10.3389/fmedt.2022.997123/full [Google Scholar] [Crossref]

8. Liu H., et al. (2023). Metal nanoparticles as a potential technique for the diagnosis and treatment of gastrointestinal cancer: a comprehensive review. Cancer Cell International, 23, 3115. https://cancerci.biomedcentral.com/articles/10.1186/s12935-023-03115-1 [Google Scholar] [Crossref]

9. Nanotechnology-based strategies for gastric cancer imaging and treatment. (2021). RSC Advances. https://pubs.rsc.org/en/content/articlehtml/2021/ra/d1ra0194 [Google Scholar] [Crossref]

10. Chen, L., Zhang, X., & Wu, Y. (2024). Mesoporous silica nanoparticles in colorectal cancer therapy: Dual- and multi-stimuli responsive strategies. arXiv preprint arXiv:2409.18809. https://arxiv.org/abs/2409.18809 [Google Scholar] [Crossref]

11. Gupta, R., Sharma, V., & Singh, A. (2025). Magnetic nanoparticles and drug delivery systems for anti-cancer applications: A review. Nanomaterials, 15(4), 285. https://www.mdpi.com/2079-4991/15/4/285 [Google Scholar] [Crossref]

12. Patra, J. K., Das, G., & Shin, H. S. (2023). Nanoparticle-based materials in anticancer drug delivery: Progress and challenges. Journal of Controlled Release, 356, 20–35. https://pubmed.ncbi.nlm.nih.gov/37954330/ [Google Scholar] [Crossref]

13. Rahman, M., Ali, H., & Khan, S. (2023). Chitosan-based nanoparticles for drug delivery: Recent advances and cancer applications. Frontiers in Nanotechnology, 5, 11408389. https://pmc.ncbi.nlm.nih.gov/articles/PMC11408389/ [Google Scholar] [Crossref]

14. Wang, J., Li, Q., & Zhou, H. (2024). Programmable lipid nanoparticles: Exploring the four-domain model for targeted drug delivery. arXiv preprint arXiv:2408.05695. https://arxiv.org/abs/2408.05695 [Google Scholar] [Crossref]

15. Almeida, F., Costa, M., & Ribeiro, C. (2024). Smart drug-delivery systems for cancer Nano therapy: Protein coronas and immune evasion strategies. arXiv preprint arXiv:2401.11192. https://arxiv.org/abs/2401.11192 [Google Scholar] [Crossref]

16. Wang, J., Li, Q., & Zhou, H. (2024). Programmable lipid nanoparticles: Exploring the four-domain model for targeted drug delivery. arXiv preprint arXiv:2408.05695. https://arxiv.org/abs/2408.05695 [Google Scholar] [Crossref]

17. Maeda H. (2021). EPR effect in cancer therapy. J Control Release.( epr) [Google Scholar] [Crossref]

18. Zou J., Chen S., Liu W., Wang Y., Zheng D., Sun W., Xu S., Wei W., Wang S. (2025). Nanoformulation-based drug delivery systems for the treatment of gastric cancer: recent developments and future prospects. Nanoscale Horizons. [Google Scholar] [Crossref]

19. Liu H., et al. (2023). Metal nanoparticles as a potential technique for the diagnosis and treatment of gastrointestinal cancer: a comprehensive review. Cancer Cell International, 23, 3115. [Google Scholar] [Crossref]

20. Zhang Y., et al. (2022). Applications of nanomaterials for gastrointestinal tumours: A review. Frontiers in Medical Technology, 4, 997123. [Google Scholar] [Crossref]

21. Nanotechnology-based strategies for gastric cancer imaging and treatment. (2021). RSC Advances. [Google Scholar] [Crossref]

22. Correa P., Piazuelo M.B. (2012). The gastric precancerous cascade. J Dig Dis, 13(1), 2–9. [Google Scholar] [Crossref]

23. Parodi, A., Buzaeva, P., Nigovora, D. et al. Nanomedicine for increasing the oral bioavailability of cancer treatments. J Nanobiotechnol 19, 354 (2021). https://doi.org/10.1186/s12951-021-01100-2 [Google Scholar] [Crossref]

24. Varzandeh M, Sabouri L, Mansouri V, Gharibshahian M, Beheshtizadeh N, Hamblin MR, Rezaei N. Application of nano-radiosensitizers in combination cancer therapy. Bioeng Transl Med. 2023 Feb 10;8(3): e10498. Doi: 10.1002/btm2.10498. PMID: 37206240; PMCID: PMC10189501 [Google Scholar] [Crossref]

25. Inoue, M. (2024). Epidemiology of gastric cancer—Changing trends and global disparities. Cancers, 16(17), 2948. https://doi.org/10.3390/cancers1 [Google Scholar] [Crossref]

26. Shanker N, Mathur P, Das P, Sathishkumar K, Martina Shalini AJ, Chaturvedi M. Cancer scenario in North-East India & need for an appropriate research agenda. Indian J Med Res. 2021 Jul;154(1):27-35. Doi: 10.4103/ijmr. IJMR 34720. PMID: 34782528; PMCID: PMC8715693. [Google Scholar] [Crossref]

27. Volume 13 – 2025 | https://doi.org/10.3389/fbioe.2025.1565999 [Google Scholar] [Crossref]

28. Parodi, A., Buzaeva, P., Nigovora, D. et al. Nanomedicine for increasing the oral bioavailability of cancer treatments. [Google Scholar] [Crossref]

29. J Nanobiotechnol 19, 354 (2021). https://doi.org/10.1186/s12951-021-01100-2 [Google Scholar] [Crossref]

• The Impact of Ownership Structure on Dividend Payout Policy of Listed Plantation Companies in Sri Lanka
• Urban Sustainability in North-East India: A Study through the lens of NER-SDG index
• Performance Assessment of Predictive Forecasting Techniques for Enhancing Hospital Supply Chain Efficiency in Healthcare Logistics
• The Fractured Self in Julian Barnes' Postmodern Fiction: Identity Crisis and Deflation in Metroland and the Sense of an Ending
• Impact of Flood on the Employment, Labour Productivity and Migration of Agricultural Labour in North Bihar