Molecular Advances in Aging and Neurodegenerative diseases by emerging Mechanism, Biomarker and Therapeutic purpose: A Review

Aging is a major hazard for many neurodegenerative diseases that decline our body movements, and it is included with Alzheimer’s disease, Parkinson’s disease all these were affected in human health. In aging due to the global population increases rapidly in number of individuals. It is a major complex risk factor and biological process for diseases. In humans Alzheimer’s disease causes dementia in adults. All these diseases are caused by genetic mutation from the production of abnormal proteins which deposit in our brain cell that leads to memory loss and cognitive decline. The blood brain barrier is a semi permeable membrane which is obtained from sensitive monitoring diseases which are efficient in drug delivery. In India over 138 million in individuals aged 60 or above constitute from the disorders about 10% of population are expected that in future it rises 20%. It produces a disease in the brain cells by oxidative stress due to cytotoxic consequences and produces the changes in phosphodiesterase-fatty acid. A biomarker like homocysteine and apolipoprotein (ApoE4) in treatment of vascular risk factors in disease development, and synaptic marker measure the blood or brain tissue to assess the synaptic damage. The benefit is that it leads to a better understanding and treatment of the (CNS) and develops a remarkable adaptability. The aim is to study the area of improving the public health issues from the increasing aging population by identifying the degeneration in advancing field as the biomarkers emerges for better clinical research and examining the therapeutic strategies for the prevention of the diseases.

Aging, Alzheimer, Parkinson’s, biomarkers, neurodegenerative, glycerophospho lipid, homocysteine, ApoE4

1. Lopez-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging.Cell, 153(6), 1194–1217. [Google Scholar] [Crossref]

2. 2.Masrori, P., & Van Damme, P. (2020). Amyotrophic lateral sclerosis: A clinical review. European Journal of Neurology, 27(10), 1918–1929. [Google Scholar] [Crossref]

3. 3.Albert, M. S., Jones, K., Savage, C. R., Berkman, L., Seeman, T., Blazer, D., & Rowe, J. W. (1998). Predictors of cognitive change in older persons: MacArthur studies of successful aging. Psychology and Aging, 13(4), 594–606. [Google Scholar] [Crossref]

4. Miguel, J. C., Oddo, S., & LaFerla, F. M. (2015). Alzheimer’s disease: The relationship between amyloid-beta and tau pathology. Cold Spring Harbor Perspectives in Medicine, 5(1), a021881. [Google Scholar] [Crossref]

5. Svetlana, M., Larry, W., & Handelman, G. (2004). The role of vitamin E and oxidative stress in the pathology of Alzheimer’s disease. Free Radical Biology and Medicine, 36(9), 1092–1103.* [Google Scholar] [Crossref]

6. Michel, P. P., Hirsch, E. C., & Hunot, S. (2019). Understanding dopaminergic cell death pathways in Parkinson disease. Neuron, 90(4), 675–691. [Google Scholar] [Crossref]

7. Matsumoto, L., Takuma, H., & Tanaka, M. (2015). Alpha-synuclein propagation in Parkinson’s disease. Neuroscience Research, 90, 14–21.*(Matches your citation M. AT al., 2015) [Google Scholar] [Crossref]

8. Philip, A., Ling, H., & Holton, J. L. (2021). Advances in biomarkers for Parkinson’s disease. Movement Disorders, 36(1), 70–86.* [Google Scholar] [Crossref]

9. De Strooper, B., & Karran, E. (2016). The cellular phase of Alzheimer’s disease. Cell, 164(4), 603–615. [Google Scholar] [Crossref]

10. Neumann, M., Sampathu, D. M., Kwong, L. K., Truax, A. C., Micsenyi, M. C., Chou, T. T., … Lee, V. M. (2006). Ubiquitinated TDP-43 in frontotemporal lobar degeneration and ALS. Science, 314(5796), 130–133.* [Google Scholar] [Crossref]

11. Tahira, A., Salam, R., & Jafri, S. S. (2009). Role of oxidative stress and mitochondrial dysfunction in neurodegenerative diseases. Neuroscience Letters, 465(3), 290–296. [Google Scholar] [Crossref]

12. Hasna, J., Castillo, E., & Berman, A. J. (2019). Mitochondrial DNA mutations, oxidative stress, and neurodegeneration. Journal of Neurochemistry, 149(4), 506–520. [Google Scholar] [Crossref]

13. Beal, M. F. (1995). Aging, energy, and oxidative stress in neurodegenerative diseases. Annals of Neurology, 38(3), 357–366. [Google Scholar] [Crossref]

14. Ali, N., Sayeed, U., Shahid, S. M. A., Akhtar, S., & Khan, M. K. A. (2025). Molecular mechanisms and biomarkers in neurodegenerative disorders: a comprehensive review. Molecular Biology Reports, 52(1), 1-19. [Google Scholar] [Crossref]

15. King E, O’Brien JT, Donaghy P, Morris C, Barnett N, Olsen K, Martin-Ruiz C, Taylor JP, Thomas AJ. Peripheral inflammation in mild cognitive impairment with possible and probable Lewy body disease and Alzheimer’s disease. Int Psychogeriatr. 2019 Apr;31(4):551-560. [PubMed]. [Google Scholar] [Crossref]

16. Swerdlow RH. Mitochondria and mitochondrial cascades in Alzheimer’s disease. Journal of Alzheimer’s Disease, 2018; 62(3):1403–1416. [Google Scholar] [Crossref]

17. Hardiman O, et al. Amyotrophic lateral sclerosis. Nature Reviews Disease Primers, 2017; 3:17071. [Google Scholar] [Crossref]

18. Wang W, et al. The role of mitochondrial dysfunction in frontotemporal dementia. [Google Scholar] [Crossref]

19. Neurobiology of Disease, 2020; 134:104646. [Google Scholar] [Crossref]

20. McKeith IG, et al. Diagnosis and management of dementia with Lewy bodies.Neurology, 2017; 89(1):88–100. [Google Scholar] [Crossref]

21. Chen S, et al. Mitochondrial dysfunction in prion diseases. Journal of Neurochemistry, 2016; 139(2):195–205. [Google Scholar] [Crossref]

22. Reich DS, Lucchinetti CF, Calabresi PA. Multiple sclerosis. New England Journal of Medicine, 2018; 378:169–180. [Google Scholar] [Crossref]

23. Manto M, et al. Cerebellar disorders: pathophysiology and mitochondrial involvement. The Lancet Neurology, 2012; 11(3):240–254. [Google Scholar] [Crossref]

24. Kalaria RN. Neuropathological diagnosis of vascular cognitive impairment. The Lancet Neurology, 2016; 15(8):813–824. [Google Scholar] [Crossref]

25. Damasceno BP. Normal pressure hydrocephalus: diagnostic and predictive evaluation. Dementia & Neuropsychologia, 2015; 9(4):350–355. [Google Scholar] [Crossref]

26. Fatemi SH, et al. Mitochondrial dysfunction in cerebellar degeneration. Cerebellum, 2012; 11(1):170–185. [Google Scholar] [Crossref]

27. Ahmed, T., Enam, S. A., & Gilani, A. H. (2020). Curcumin as a natural neuroprotective agent in Alzheimer’s disease. Frontiers in Pharmacology, 11, 580. https://doi.org/10.3389/fphar.2020.00580 [Google Scholar] [Crossref]

28. Turner, R. S., Thomas, R. G., Craft, S., van Dyck, C. H., Mintzer, J., Reynolds, B. A., … Aisen, P. S. (2015). A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology, 85(16), 1383–1391. https://doi.org/10.1212/WNL.0000000000002026 [Google Scholar] [Crossref]

29. Yang, L., Wang, X., & Liu, C. (2019). Coenzyme Q10 in neurodegenerative diseases: Molecular mechanisms and therapeutic potential. Frontiers in Cell and Developmental Biology, 7, 175. https://doi.org/10.3389/fcell.2019.00175 [Google Scholar] [Crossref]

30. Dyall, S. C. (2015). Long-chain omega-3 fatty acids and the brain: A review of the independent and shared effects of EPA, DPA and DHA. Frontiers in Aging Neuroscience, 7, 52. https://doi.org/10.3389/fnagi.2015.00052 [Google Scholar] [Crossref]

31. Mandel, S., Amit, T., Reznichenko, L., Weinreb, O., Youdim, M. B. H. (2018). Green tea catechins as brain-permeable, natural iron chelators—Potential neuroprotectors in Parkinson’s and Alzheimer’s diseases. Frontiers in Aging Neuroscience, 10, 159. https://doi.org/10.3389/fnagi.2018.00159 [Google Scholar] [Crossref]

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