Adaptogenic and Stress-Relieving Herbs in Mental Health

Authors

Sachin, K. Hodgar Sanket A.

Dr kolpe Institute of Pharmacy, Kolpewadi kopargaon. (India)

Bombale Sarthak S.

Dr kolpe Institute of Pharmacy, Kolpewadi kopargaon. (India)

Kshirsagar Vaishnavi V.

Dr kolpe Institute of Pharmacy, Kolpewadi kopargaon. (India)

Ghule Sinare Akshay R.

Dr kolpe Institute of Pharmacy, Kolpewadi kopargaon. (India)

Article Information

DOI: 10.51584/IJRIAS.2025.101100026

Subject Category: Pharmaceutics

Volume/Issue: 10/11 | Page No: 292-301

Publication Timeline

Submitted: 2025-11-10

Accepted: 2025-11-20

Published: 2025-12-06

Abstract

Mental health disorders such as stress, anxiety, and depression have become a major global concern, significantly affecting quality of life and productivity. Conventional pharmacological treatments, although effective, are often associated with adverse effects and long-term dependency. In recent years, adaptogenic and stress-relieving herbs have gained growing attention as safer, holistic alternatives in the management of mental health disorders. Adaptogens are natural substances that enhance the body’s resilience to physical, emotional, and environmental stressors by modulating the hypothalamic–pituitary–adrenal (HPA) axis and maintaining homeostasis. Herbs such as Withania somnifera (Ashwagandha), Bacopa monnieri (Brahmi), Ocimum sanctum (Tulsi), Panax ginseng (Ginseng), and Rhodiola rosea have demonstrated promising results in reducing stress, improving cognition, regulating neurotransmitter activity, and protecting against oxidative damage. Several clinical studies support their role in alleviating symptoms of anxiety, depression, and stress-related disorders, with minimal side effects. However, standardization, dosage optimization, and large-scale clinical validation remain challenges for their wider acceptance in modern medicine. This review aims to highlight the pharmacological mechanisms, therapeutic benefits, and clinical evidence of adaptogenic herbs in promoting mental well-being, thereby offering a natural and sustainable approach to mental health care.

Keywords

Adaptogens, Stress-relieving herbs, mental health, Anxiety, Depression, Herbal medicine

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References

1. Chandrasekhar K, Kapoor J, Anishetty S. “A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults.” Indian Journal of Psychological Medicine. 2012;34(3):255-62. PMC [Google Scholar] [Crossref]

2. Lopresti AL, et al. “A randomized, double-blind, placebo-controlled study: Ashwagandha’s stress-relieving effects may occur via its moderating effect on the hypothalamus-pituitary-adrenal axis.” 2019. PubMed [Google Scholar] [Crossref]

3. Pandit S, et al. “Effects of Withania somnifera Extract in Chronically Stressed Adults: A Dose-Dependent Randomized, Double-Blinded, Placebo-Controlled Study.” Nutrients. 2024;16(9):1293. MDPI [Google Scholar] [Crossref]

4. Lopresti AL, et al. “An Investigation into the Stress-Relieving and Pharmacological Activity of an Ashwagandha Extract on Stress, Anxiety and Hormone Production in Healthy Adults.” MD Journal. 2019. Lippincott Journals [Google Scholar] [Crossref]

5. Verma N, et al. “Safety of Ashwagandha Root Extract: A Randomized, Double-Blind, Placebo-Controlled Trial in Males and Females.” 2021. ScienceDirect [Google Scholar] [Crossref]

6. Puttaswamy N, et al. “Efficacy of Ashwagandha Extract Formulation (ASVAMAN®) on Improvement of Energy and Endurance: A Randomized, Double-blind, Placebo-controlled Study in Healthy Adults.” European Journal of Medical and Health Sciences. 2025;7(2):88-93. Eur J Med Health Sci [Google Scholar] [Crossref]

7. Stojcheva EI, et al. “The Effectiveness of Rhodiola rosea L. Preparations in Mild to Moderate Depression, Anxiety and Stress: A Systematic Review and Metaanalysis.” 2022. PMC [Google Scholar] [Crossref]

8. Mao JJ, et al. “Rhodiola rosea therapy for major depressive disorder: a randomized, double-blind, placebo-controlled study.” 2014. PMC [Google Scholar] [Crossref]

9. Gao L, et al. “Antidepressant effects of Rhodiola capsule combined with sertraline in patients with depression disorder.” 2020. ScienceDirect [Google Scholar] [Crossref]

10. Mao JJ, et al. “Rhodiola rosea vs sertraline in major depressive disorder: Efficacy, tolerability and safety.” Psychopharmacology. 2015. ScienceDirect [Google Scholar] [Crossref]

11. Anghelescu IG. “Stress management and the role of Rhodiola rosea: a review.” 2018. Taylor & Francis Online [Google Scholar] [Crossref]

12. Sprengel M, et al. “A review of its mechanisms, health benefits, and role in sports: Withania somnifera (Ashwagandha).” Nutrition & Metabolism. 2025. BioMed Central [Google Scholar] [Crossref]

13. “Rhodiola rosea: Clinical Evidence for Adaptogenic and Neuroprotective Effects.” Liebert Publications.2024. Liebert Publishing [Google Scholar] [Crossref]

14. Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue: Study results for 2 × 200 mg dosage. 2017. Karger [Google Scholar] [Crossref]

15. Global Psychiatry — Konstantinos F, et al. “The effects of Rhodiola Rosea supplementation on depression, anxiety and mood – A Systematic Review.” 2020. globalpsychiatry.co.uk [Google Scholar] [Crossref]

16. ClinicalTrials.gov. “Effects of a Proprietary Ashwagandha Extract on Stress Reduction: A Three-Arm Randomized, Double-Blinded, Placebo Controlled Clinical Trial.” NCT06793891. ClinicalTrials.gov [Google Scholar] [Crossref]

17. ClinicalTrials.gov. “Long Term Safety and Efficacy of KSM-66 Ashwagandha in Long-TermAdministration over 12 months.” NCT06244147. ClinicalTrials.gov [Google Scholar] [Crossref]

18. ClinicalTrials.gov. “A Clinical Trial to Study the Effects of Sensoril® for Patients with Generalized Anxiety.” NCT01311180. ClinicalTrials.gov (Review) Examine.com entry: Rhodiola rosea research summary on mood, stress, stamina. Examine. [Google Scholar] [Crossref]

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