Design and Performance Test of a Prototype MRI-Compatible Cascaded Pressure Microsensor

In this paper, the design, simulation, fabrication and characterization of a prototype single fiber MRI compatible cascaded pressure sensor is presented. This paper represents the extended version of earlier communication on this topic. In addition to the earlier communication, in this paper, we report on a crucial design requirement: the immunity to Electro-Magnetic Interference (EMI). This immunity has been experimentally tested by combining the prototype sensors with a Siemens 1.5T Magnetic Resonance Imaging (MRI) apparatus at Haga Hospital (The Hague). No disturbance was observed during a full MRI imaging cycle. The system allows for long lasting usage in the range -50 mmHg to 300 mmHg without damage to the membrane. A static pressure resolution (averaged over the array) of 3.6 mmHg was found, a performance that needs improvement in the future. Simulations show that the desired resolution of 1.0 mmHg is feasible within this design approach. The dynamical response allows for registration of dynamical features up to 20 Hz, already meeting dynamical requirements of this low-cost sensing system and already exceeding expectations expressed in advance. Future work includes further miniaturization, catheter integration, improvement of static pressure resolution, tackling separation of temperature-pressure crosstalk by implementing alternating independent Fibre Bragg Grating (FBG) temperature sensors in the array and further enhancing dynamical properties.

Photonic Integrated Circuit; Microring Resonator (MRR); Cardiovascular diseases; Cardiac Performance

1. L. Arntzen, D. Boesten, et. al., “MRI-Compatible Cascaded Blood Pressure Microsensor”, The Eighth International Conference on Advances in Sensors, Actuators, Metering, Pages: 41 to 44, April 24, 2023, Published in: ALLSENSORS 2023, Venice, Italy Copyright (c) IARIA, ISSN: 2519-836X, ISBN: 978-1-68558-083-4083-4. [Google Scholar] [Crossref]

2. K. O. Hill, et. al., Photo-sensitivity in optical fiber waveguides: application to reflection fiber fabrication”, Appl. Phys. Lett. 32 (10): 647, doi:10.1063/1.89881. [Google Scholar] [Crossref]

3. Campbell et al., “Development of a prototype bridge scour sensor exploiting vortex-induced vibrations”, Proceedings of the Institution of Civil Engineers, Bridge Engineering, doi:10.1680/jbren.23.00034. [Google Scholar] [Crossref]

4. J. W. Arkwright et. al., “Fiber Optic Pressure Sensing Arrays for Monitoring Horizontal and Vertical Pressures Generated by Traveling Water Waves”, IEEE Sensors Journal, Vol. 14, No. 8, August 2014. [Google Scholar] [Crossref]

5. J. W. Arkwright et. al., “In-vivo Demonstration of a High Resolution Optical Fiber Manometry Catheter for Diagnosis of Gastrointestinal Motility Disorders”, Optics Expres 4500, Vol. 17, No. 6. [Google Scholar] [Crossref]

6. Nayak et al., “Enhancing fault detection and predictive maintenance of rotating machinery with Fiber Bragg Grating sensor and machine learning techniques”, International Journal of Information Technology, https://doi.org/10.1007/s41870-024-02256-4. [Google Scholar] [Crossref]

7. J. S. van den Brink, ”Concepts in Magnetic Resonance Part B”, Review Article, Thermal Effects Associated with RF Exposures in Diagnostic MRI: Overview of Existing and Emerging Concepts of Protection, 17 June 2019, https://doi.org/10.1155/2019/9618680. [Google Scholar] [Crossref]

8. J. Overgaard, “The heat is (still) on – The past and future of hyperthermic radiation oncology, Radiotherapy and Oncology”, Volume 109, ISSUE 2, P185-187, November 2013, DOI: https://doi.org/10.1016/j.radonc.2013.11.004 [Google Scholar] [Crossref]

9. Q. Shao et. al., “Tumor therapeutic response monitored by telemetric temperature sensing, a preclinical study on immunotherapy and chemotherapy”, Scientific Reports volume 13, Article number: 7727 (2023) [Google Scholar] [Crossref]

10. A. R. Niknam, S. Dodge, M. Hajian and M. A. Ansari, “Characterization of microwave heating for hyperthermia cancer treatment”. Waves in Random and Complex Media, 34(1), 211–225, https://doi.org/10.1080/17455030.2021.1905911. [Google Scholar] [Crossref]

11. Ioannis Androulakis a, Rob M.C. Mestrom b, Sergio Curto Inger-Karine K. Kolkman-Deurloo a, Gerard C. van Rhoon, “Pre-clinical prototype validation and characterization of a thermo-brachytherapy system for interstitial hyperthermia and high-dose rate brachytherapy”, Physics and Imaging in Radiation Oncology,https://doi.org/10.1016/j.phro.2024.100606 [Google Scholar] [Crossref]

12. David M. Smadja, “Hyperthermia for Targeting Cancer and Cancer Stem Cells: Insights from Novel Cellular and Clinical Approaches”, Stem Cell Reviews and Reports, https://doi.org/10.1007/s12015-024-10736-0 [Google Scholar] [Crossref]

13. M. Szwed, A. Marczak, “Application of Nanoparticles for Magnetic Hyperthermia for Cancer Treatment”, The Current State of Knowledge, Cancers 2024, 16(6), 1156; https://doi.org/10.3390/cancers16061156. [Google Scholar] [Crossref]

14. Heart Foundation, “Cardiovascular diseases in the Netherlands 2021”, https://hartstichting-hartstichting-portal-p01.s3.eu-central-1.amazonaws.com/s3fs-public/2022-11/hart-en-vaatziekten-nederland-cijfers-2021.pdf?, [retrieved: March, 2026]. [Google Scholar] [Crossref]

15. K. Peels, N. H. J. Pijls, B. de Bruyne. ”Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses”, New English Journal of Medicine, June 1996. [Google Scholar] [Crossref]

16. Ł. Dziuda, M. Krej and F. W. Skibniewski, ”Fiber Bragg Grating Strain Sensor Incorporated to Monitor Patient Vital Signs During MRI,” in IEEE Sensors Journal, vol. 13, no. 12, pp. 4986-4991, doi: 10.1109/JSEN.2013.2279160. [Google Scholar] [Crossref]

17. A. Kumar, D. J. Patton, M. G. Friedrich, ”The emerging clinical role of cardiovascular magnetic resonance imaging”, Jun 2010, publisher: Pulsus Group [Google Scholar] [Crossref]

18. UMC Utrecht,”7T-MRI”, https://www.umcutrecht.nl/nl/wetenschappelijk-onderzoek/7t-mri, [retrieved: March 2026].https://en.wikipedia.org/wiki/Venturi_effect [retrieved: March 2026]. [Google Scholar] [Crossref]

19. J. E. Hall, ”Guyton and Hall Textbook of Medical Physiology”, pp. 155-166, 2003. [Google Scholar] [Crossref]

20. M. F. O’Rourke, ”Time domain analysis of the arterial pulse in clinical medicine”, Med Biol Eng Comput 47, pp. 119–129, Feb 2009, publisher: IFMBE. [Google Scholar] [Crossref]

21. B. Uyang et. al., Integrated photonics Interferometric Interrogator for a Ring-Resonator Ultrasound Sensor, OPTICS EXPRESS 23408, Vol. 27, No. 16, 5 Aug 2019. [Google Scholar] [Crossref]

22. B. Uyang et. al., On-chip silicon Mach–Zehnder Interferometer, Sensor for Ultrasound Detection, Optics Letters, Vol. 44, No. 8, 15 April 2019. [Google Scholar] [Crossref]

23. FBGS, Draw Tower Gratings, Overview, https://fbgs.com/components/draw-tower-gratings-dtgs/, retrieved: March 2026. [Google Scholar] [Crossref]

24. Femto Sensing International, FAZT I4G INTERROGATOR Datasheet, https://femtosensing.com/wp-content/uploads/2020/01/ FSI-FAZ-I4G-Interrogator-Datasheet-V4.pdf, retrieved: Feb 2023. [Google Scholar] [Crossref]

25. Norland Products, Norland Optical Adhesive 65 Technical Datasheet, https://norlandproducts.com/adhesives, [retrieved: March 2026]. [Google Scholar] [Crossref]

26. COMSOL Multiphysics® V5.6 https://www.comsol.com, [retrieved: March 2026. [Google Scholar] [Crossref]

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