Malaria and Hepatitis-B Co-Infection Among Pregnant Women in Selected Health Facilities in Ikwerre Local Government Area, Rivers State, Nigeria.

This study was done to determine the prevalence of malaria and hepatitis B co-infection among pregnant women attending ante-natal in three health centers, samples were collected from Mbodo Aluu health care center, Igwuruta general hospital and Ozuaha primary health care center between August to November 2024. Ethical approval was sought from the ethics committee of the university of Port Harcourt and ministry of health Rivers State. Malaria parasite was determined using the gold standard microscopic procedure, while hepatitis B virus was determined using rapid serology assay diagnostic kit. Urinalysis was done using combi 9 dipstick stripe. Three hundred and eighty (380) consented subjects were examined. Two hundred and forty-seven (247) participated from Mbodo, one hundred and twenty-three (123) from Igwuruta and ten from Ozuaha. The total prevalence of Malaria in this study was 16.84%, hepatitis B 3.42% and Proteinuria 25.79%. Malaria and hepatitis B co-infection was 1.58%, malaria + proteinuria recorded a prevalence of 4.58%, hepatitis B + proteinuria recorded. The prevalence of 4.58%, malaria + hepatitis B + Proteinuria recorded 0.79%. Malaria and hepatitis B was significantly high among the age group from 20 below (2.94%) (p<0.5). The results also shows that the highest prevalence was among the second trimester (52.29%). The prevalence rate of malaria, Hepatitis B and their co-infections in the present study is relatively high. Therefore, it is recommended that regular screening of pregnant women for these Infections be sustained to forestall the undesirable consequences of these infections.

Prevalence, Malaria, Hepatitis B, Co-infection, Proteinur

1. Abah A E, Udoidang I N (2019). Co-Infection of Malaria and Hepatitis B Virus in Port Harcourt, Rivers State, Nigeria. Int J Infect.;6(4): e97033. [Google Scholar] [Crossref]

2. Adegnika, A. A., and Kremsner, P. G. (2012). Antenatal care and prevention of malaria in pregnancy in Africa: From policy to practice. Current Opinion in Infectious Diseases, 25(5), 457–463. [Google Scholar] [Crossref]

3. Adeniran, A. S., Olaniran, O., and Afolabi, O. (2016). Malaria in pregnancy: Knowledge and prevention among antenatal clinic attendees in a secondary health facility in Nigeria. Journal of Basic and Clinical Reproductive Sciences, 5(1), 13–18. [Google Scholar] [Crossref]

4. Adeyemo SA, Olajide TO, Akinyemi KO, Adesina BA, Ibitoye RT. (2022). Malaria prevalence among school-aged children in Ibadan, Oyo State, Nigeria: a cross-sectional study. Malar J. 2022; 21:123. doi:10.1186/s12936-022-04123-7. [Google Scholar] [Crossref]

5. Aernan, P. T., Adogo, L. Y., and Shaibu, J. O. (2011). Hepatitis B virus and malaria co-infection in patients attending a tertiary hospital in Nigeria. Journal of Medical Science, 11(2), 112–115. [Google Scholar] [Crossref]

6. Aernan, P. T., Adogo, L. Y., and Shaibu, J. O. (2011). Hepatitis B virus and malaria co-infection in patients attending a tertiary hospital in Nigeria. Journal of Medical Science, 11(2), 112–115. [Google Scholar] [Crossref]

7. Ahemad, S. (2022). Malaria-induced kidney injury: Pathophysiology and clinical outcomes. International Journal of Nephrology and Renovascular Disease, 15, 43–52. https://doi.org/10.2147/IJNRD.S345678 [Google Scholar] [Crossref]

8. Anjorin, S., Okolie, E., and Yaya, S. (2023). Malaria profile and socioeconomic predictors among under-five children: an analysis of 11 sub-Saharan African countries. Malaria Journal, 22, 55. [Google Scholar] [Crossref]

9. Awosolu, O. B., Yahaya, Z. S., Haziqah, M. T. F., Simon-Oke, I. A., and Fakunle, C. (2021). A cross-sectional study of the prevalence, density, and risk factors associated with malaria transmission in urban communities of Ibadan, Southwestern Nigeria. Heliyon, 7(1). [Google Scholar] [Crossref]

10. Bawa, S. B. (2014). The socio-economic burden of malaria in sub-Saharan Africa. African Research Review, 8(1), 119–138. [Google Scholar] [Crossref]

11. Brown, D.D., Solomon, S., Lerner, D. et al. (2020). Malaria and acute kidney injury. Pediatr Nephrol 35, 603–608 (2020). [Google Scholar] [Crossref]

12. Centers for Disease Control and Prevention (CDC). (2021). Hepatitis B questions and answers for health professionals. [Google Scholar] [Crossref]

13. Corrêa, G. (2017). Malaria in pregnancy: Management and prevention strategies. Brazilian Journal of Health Review, 3(2), 122–132. [Google Scholar] [Crossref]

14. Dabo, N. T., Sharif, A. A., Muhammed, Y., and Sarkinfada, F. (2015). Malaria and Hepatitis B co-infection in patients with febrile illnesses attending general outpatient unit of the Murtala Muhammed Specialist Hospital, Kano, Northwest Nigeria. Bayero Journal of Pure and Applied Sciences, 8(1), 89-95. [Google Scholar] [Crossref]

15. Donnelly S (2022) The immunology of parasite infections: Grand challenges. Front. Parasitol. 1:1069205 [Google Scholar] [Crossref]

16. European Centre for Disease Prevention and Control (ECDC). (2024). "Hepatitis B Annual Epidemiological Report for 2022 [Google Scholar] [Crossref]

17. Freimanis, G. L., Tetteh, K. K. A., Rowe, J. A., and Drakeley, C. J. (2012). The impact of co-infection with hepatitis B virus on the severity of malaria. Journal of Infectious Diseases, 205(4), 627–635. [Google Scholar] [Crossref]

18. Humphreys, N. E., and Grencis, R. K. (2002). Effects of Ageing on the Immunoregulation of Parasitic Infection. Infection and Immunity, 70(9), 5148-5157. [Google Scholar] [Crossref]

19. Ibrahim A, Ma’an N, Gondwe T (2017). Prevalence and determinants of malaria parasitaemia among pregnant women attending antenatal clinics in Kaduna South LGA, Nigeria. BMC Infect Dis. 2017 Jul 7;17(1):350. doi:10.1186/s12879-017-2502-2. PMID:28667521. [Google Scholar] [Crossref]

20. Ijoma, U. N., Meka, I. A., Omotowo, B., Nwagha, T. U., Obienu, O., Onodugo, O. D., and Ugwu, E. O. (2021). Sero-prevalence of Hepatitis B virus infection: A cross-sectional study of a large population of health care workers in Nigeria. Nigerian Journal of Clinical Practice, 24(1), 38-44. [Google Scholar] [Crossref]

21. Jeanne, A. N. (2024). The Role of Climate and Environmental Factors in Malaria Transmission in Nigeria: Challenges and Prospects. INOSR Applied Sciences, 12(3), 6-10 [Google Scholar] [Crossref]

22. Kaiser, J. (2013). Malaria’s toll: Still a leading killer of children. Science, 339(6115), 1249–1250. [Google Scholar] [Crossref]

23. Kolawole, O. M., & Kana, B. D. (2018). Co-infection of malaria and hepatitis B virus: A neglected public health problem. Journal of Advances in Medicine and Medical Research, 26(6), 1–8. https://doi.org/10.9734/JAMMR/2018/41868 [Google Scholar] [Crossref]

24. Kolawole, O. M., Durowade, K. A., and Adekanle, D. A. (2012). Prevalence of hepatitis B surface antigenemia in asymptomatic pregnant women in Oshogbo, Nigeria. African Journal of Clinical and Experimental Microbiology, 13(2), 68–72. [Google Scholar] [Crossref]

25. Mabbott NA (2018). The Influence of Parasite Infections on Host Immunity to Co-infection With Other Pathogens. Front. Immunol. 9:2579. [Google Scholar] [Crossref]

26. Mbaawuaga, E. M., Enenebeaku, M. N. O., and Okopi, J. A. (2008). Hepatitis B virus (HBV) seroprevalence among pregnant women in Makurdi, Nigeria. African Journal of Biomedical Research, 11(2), 155–159. [Google Scholar] [Crossref]

27. Mmbando BP, Davis SM, Mandara CI, Greenhill AR, Msellem MI (2016). Malaria prevalence among outpatients across three health facilities in Kilombero Valley, Tanzania. PLoS One. 2016 Aug 25;11(8): e0160634. doi: 10.1371/journal.pone.0160634. PMID:27529234. [Google Scholar] [Crossref]

28. Musibau, A. A., Sule, O. A., and Olukolade, B. F. (2017). Implementation of the Global Technical Strategy for Malaria 2016–2030 in Nigeria: Challenges and prospects. Public Health Frontiers, 2(1), 21–27. [Google Scholar] [Crossref]

29. Nwele, D. E., Onyali, I. O., Iwueze, M. O., Elom, M. O., & Uguru, O. E. S. (2022). Malaria endemicity in the rural communities of Ebonyi State, Nigeria. The Korean journal of parasitology, 60(3), 173. [Google Scholar] [Crossref]

30. Obeagu, E. I., Ogbonna, U. S., Nwachukwu, A. C., Ochiabuto, O., Enweani, I. B., and Ezeoru, V. C. (2021). Prevalence of Malaria with Anaemia and HIV status in women of reproductive age in Onitsha, Nigeria. Journal of Pharmaceutical Research International, 33(4), 10-19. [Google Scholar] [Crossref]

31. Ochola, L. B., Gitau, E. N., Musyoki, J. N., Mwau, M., & Muli, J. M. (2014). Co-infections of hepatitis B virus and malaria parasite in adult patients attending Thika District Hospital, Kenya. BMC Research Notes, 7(1), 333. https://doi.org/10.1186/1756-0500-7-333 [Google Scholar] [Crossref]

32. Oladepo, O., Oyediran, M. A., and Titiloye, M. A. (2010). Malaria in pregnancy: Women’s knowledge and health care seeking behavior in Ogun State, Nigeria. African Journal of Reproductive Health, 14(3), 45–52. [Google Scholar] [Crossref]

33. Olowe OE, Akinleye SO, Ibeh DC, Bello RA, Onah MN. (2021). Malaria infection rates in urban pregnant women attending antenatal clinics in Lagos, Nigeria. BMC Infect Dis. 2021; 21:456. doi:10.1186/s12879-021-06123-8. [Google Scholar] [Crossref]

34. Omatola CA, Okolo MO. (2021). Hepatitis B and Asymptomatic Malaria Infection among Pregnant Women in a Semiurban Community of North-Central Nigeria. J Environ Public Health. 2021 Nov 28; 2021:9996885. [Google Scholar] [Crossref]

35. Pindolia, D. K., Garcia, A. J., Huang, Z., Smith, D. L., Alegana, V. A., Noor, A. M., Snow, R. W., and Tatem, A. J. (2013). The demographics of human and malaria movement and migration patterns in East Africa. Malaria Journal, 12, 397. [Google Scholar] [Crossref]

36. Quiros-Roldan, E., Sottini, A., Natali, P. G., and Imberti, L. (2024). The Impact of Immune System Aging on Infectious Diseases. Microorganisms, 12(4), 775. [Google Scholar] [Crossref]

37. Rogerson, S. J., Hviid, L., Duffy, P. E., Leke, R. F., and Taylor, D. W. (2018). Malaria in pregnancy: Pathogenesis and immunity. The Lancet Infectious Diseases, 18(5), e105–e118. [Google Scholar] [Crossref]

38. Rouamba, T., Nakanabo-Diallo, S., Derra, K., (2019). Socioeconomic and environmental factors associated with malaria hotspots in the Nanoro demographic surveillance area, Burkina Faso. BMC Public Health, 19, 249. [Google Scholar] [Crossref]

39. Snow, R. W., Guerra, C. A., Noor, A. M., Myint, H. Y., and Hay, S. I. (1999). The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature, 434(7030), 214–217. [Google Scholar] [Crossref]

40. Talla, C., Itanyi, I. U., Tsuyuki, K., Stadnick, N., Ogidi, A. G., Olakunde, B. O., and Ezeanolue, E. E. (2021). Hepatitis B infection and risk factors among pregnant women and their male partners in the baby shower programme in Nigeria: a cross‐sectional study. Tropical Medicine and International Health, 26(3), 316-326. [Google Scholar] [Crossref]

41. Tam, G., Cowling, B. J., and Maude, R. J. (2021). Analysing human population movement data for malaria control and elimination. Malaria Journal, 20, 294. [Google Scholar] [Crossref]

42. Ujuju CN, Ezegwu HU, Mbata TI (2018). Prevalence of malaria parasites among febrile under-five children at four primary health centres in Enugu East LGA, Nigeria. PLoS One. 2018 Mar 14;13(3): e0193240. doi: 10.1371/journal.pone.0193240. PMID:29566033. [Google Scholar] [Crossref]

43. Usman JN, Yusuf MK, Adebayo OO, Okoro PE, Nwachukwu UA. (2020). Cross-sectional survey of malaria in adolescents in Abuja, Nigeria: prevalence and risk factors. Am J Trop Med Hyg. 2020;103(2):567–574. [Google Scholar] [Crossref]

44. van Eijk, A. M., Ayisi, J. G., Ter Kuile, F. O., Misore, A. O., Otieno, J. A., Kolczak, M. S., and Nahlen, B. L. (2011). Malaria and human immunodeficiency virus infection as risk factors for anemia in infants in Kisumu, western Kenya. American Journal of Tropical Medicine and Hygiene, 85(1), 47–56. [Google Scholar] [Crossref]

45. World Health Organization. (2012). Intermittent preventive treatment of malaria in pregnancy using sulfadoxine-pyrimethamine (IPTp-SP): Updated WHO policy recommendation. WHO. [Google Scholar] [Crossref]

46. World Health Organization. (2013). WHO policy brief for the implementation of intermittent preventive treatment of malaria in pregnancy using sulfadoxine-pyrimethamine (IPTp-SP). [Google Scholar] [Crossref]

47. World Health Organization. (2014). World malaria report 2014. World Health Organization. [Google Scholar] [Crossref]

48. WHO (World Health Organization). (2015). Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection. Geneva: WHO Press. [Google Scholar] [Crossref]

49. World Health Organization (WHO). (2017). Hepatitis B vaccines: WHO position paper–July 2017. Weekly Epidemiological Record, 92(27), 369–392. [Google Scholar] [Crossref]

50. World Health Organization (WHO). (2020). Global report on antimalarial drug efficacy and drug resistance: 2000–2019. [Google Scholar] [Crossref]

51. World Health Organization (WHO). (2024). "Hepatitis B." [Google Scholar] [Crossref]

52. Yartey, J. E. (2006). Malaria in pregnancy: Access to effective interventions in Africa. International Journal of Gynecology and Obstetrics, 94(3), 364–373. [Google Scholar] [Crossref]

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