Synthesis and Characterization of Antibacterial Agents: Spectroscopic Insights and Biological activity Evaluation

Antibacterial resistance continues to threaten public health worldwide, prompting the development of novel small-molecule antibacterial agents. Herein, we report the synthesis, spectroscopic characterization, and antibacterial activity assessment of a series of novel heterocyclic derivatives. Structural confirmation was achieved through FT-IR, 1H / 13C NMR, and mass spectrometry. Antibacterial efficacy was evaluated against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) strains. The synthesized compounds exhibited comparable or superior efficacy relative to standard antibiotics, supporting their potential as future therapeutic agents.

Antibacterial, Preparation, potential, Heterocyclic, Spectra

1. Ventola CL; The antibiotic resistance crisis: Part 1. P&T. 2015;40(4):277–283. [Google Scholar] [Crossref]

2. Brown D; Heterocycles as antibiotic scaffolds. Chem Rev. 2018;118(3):1230–1270. [Google Scholar] [Crossref]

3. Kumar A; Synthesis and antibacterial activity of benzothiazole derivatives. Bioorg Med Chem Lett. 2020;30(12):127367. [Google Scholar] [Crossref]

4. Singh P;. Evaluation of quinazoline compounds as antimicrobial agents. Eur J Med Chem. 2019; 179:645–657. [Google Scholar] [Crossref]

5. Wikler MA; Methods for dilution antimicrobial susceptibility tests. CLSI. 2018. [Google Scholar] [Crossref]

6. Jones RN; Mechanisms of action for antibacterial heterocyclic compounds. J Antimicrob Chemother. 2017;72(9):2481–2493. [Google Scholar] [Crossref]

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