The Role of AI-Based Clinical Decision Support Systems (AI-CDSS) in Modern Pharmacy Practice

Authors

Julliyan Dilleban A.

Arulmigu Kalasalingam College of Pharmacy, India (India)

Thenraja Sankar

Arulmigu Kalasalingam College of Pharmacy, India (India)

Venkateshan Narayanan

Arulmigu Kalasalingam College of Pharmacy, India (India)

Kamala devi M

Arulmigu Kalasalingam College of Pharmacy, India (India)

Denilah Pauline C

Arulmigu Kalasalingam College of Pharmacy, India (India)

Article Information

DOI: 10.47772/IJRISS.2025.910000069

Subject Category: Public Health

Volume/Issue: 9/10 | Page No: 801-804

Publication Timeline

Submitted: 2025-10-12

Accepted: 2025-10-20

Published: 2025-11-04

Abstract

Artificial intelligence-based clinical decision support systems (AI-CDSS) are emerging tools leveraging machine learning and healthcare data to aid pharmacists in managing clinical complexity. They offer real-time insights for identifying high-risk prescriptions, preventing drug interactions, and aiming to improve patient outcomes. While the strength of AI-CDSS lies in data-driven support, human-centered design focusing on trust and usability is crucial for adoption. Applications of AI-CDSS extend to patient care (e.g., disease prediction, medication adherence) and pharmacy practice, including prioritizing prescription reviews (e.g., Lumio Medication) and early detection of cognitive impairment. Although AI-CDSS shows potential in optimizing pharmacy workflows and identifying drug-related issues, direct evidence of improved patient outcomes within the pharmacy remains limited. Implementation faces challenges like technical constraints and workflow misalignment. This paper synthesizes current research, highlighting the potential of AI-CDSS to transform pharmacy practice while acknowledging the need for further investigation into their impact on patient outcomes and the practical barriers to their widespread use.

Keywords

Clinical decision support systems, Artificial intelligence

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References

1. Wang L, Zhang Z, Wang D, Cao W, Zhou X, Zhang P, Liu J, Fan X, Tian F. Human-centered design and evaluation of AI-empowered clinical decision support systems: a systematic review. Frontiers in Computer Science. 2023 Jun 2;5:1187299. [Google Scholar] [Crossref]

2. Magrabi F, Ammenwerth E, McNair JB, De Keizer NF, Hyppönen H, Nykänen P, Rigby M, Scott PJ, Vehko T, Wong ZS, Georgiou A. Artificial intelligence in clinical decision support: challenges for evaluating AI and practical implications. Yearbook of medical informatics. 2019 Aug;28(01):128-34. [Google Scholar] [Crossref]

3. Patel VL, Shortliffe EH, Stefanelli M, Szolovits P, Berthold MR, Bellazzi R, Abu-Hanna A. The coming of age of artificial intelligence in medicine. Artificial intelligence in medicine. 2009 May 1;46(1):5-17. [Google Scholar] [Crossref]

4. Yahyaoui A, Jamil A, Rasheed J, Yesiltepe M. A decision support system for diabetes prediction using machine learning and deep learning techniques. In2019 1st International informatics and software engineering conference (UBMYK) 2019 Nov 6 (pp. 1-4). [Google Scholar] [Crossref]

5. IEEE.Elani HW, Batista AF, Thomson WM, Kawachi I, Chiavegatto Filho AD. Predictors of tooth loss: A machine learning approach. PLoS One. 2021 Jun 18;16(6):e0252873. [Google Scholar] [Crossref]

6. Rosenfeld A, Benrimoh D, Armstrong C. Big data analytics and AI in mental healthcare,(2019). arXiv preprint arXiv:1903.12071. 1903. [Google Scholar] [Crossref]

7. Frangou S, Sachpazidis I, Stassinakis A, Sakas G. Telemonitoring of medication adherence in patients with schizophrenia. Telemedicine Journal & E-Health. 2005 Dec 1;11(6):675-83. [Google Scholar] [Crossref]

8. Liu C, Cao Y, Alcantara M, Liu B, Brunette M, Peinado J, Curioso W. TX-CNN: Detecting tuberculosis in chest X-ray images using convolutional neural network. In2017 IEEE international conference on image processing (ICIP) 2017 Sep 17 (pp. 2314-2318). IEEE. [Google Scholar] [Crossref]

9. Dong Y, Pan Y, Zhang J, Xu W. Learning to read chest X-ray images from 16000+ examples using CNN. In2017 IEEE/ACM international conference on connected health: applications, systems and engineering technologies (CHASE) 2017 Jul 17 (pp. 51-57). IEEE. [Google Scholar] [Crossref]

10. Kupershtein LM, Martyniuk TB, Krencin MD, Kozhemiako AV, Bezsmertnyi Y, Bezsmertna H, Kolimoldayev M, Smolarz A, Weryńska-Bieniasz R, Uvaysova S. Neural expert decision support system for stroke diagnosis. InPhotonics Applications in Astronomy, Communications, Industry, and High Energy Physics Experiments 2017 2017 Aug 7 (Vol. 10445, pp. 1060-1065). SPIE. [Google Scholar] [Crossref]

11. Corny J, Rajkumar A, Martin O, Dode X, Lajonchère JP, Billuart O, Bézie Y, Buronfosse A. A machine learning–based clinical decision support system to identify prescriptions with a high risk of medication error. Journal of the American Medical Informatics Association. 2020 Nov;27(11):1688-94. [Google Scholar] [Crossref]

12. Levivien C, Cavagna P, Grah A, Buronfosse A, Courseau R, Bézie Y, Corny J. Assessment of a hybrid decision support system using machine learning with artificial intelligence to safely rule out prescriptions from medication review in daily practice. International Journal of Clinical Pharmacy. 2022 Apr;44(2):459-65. [Google Scholar] [Crossref]

13. Balestra M, Chen J, Iturrate E, Aphinyanaphongs Y, Nov O. Predicting inpatient pharmacy order interventions using provider action data. JAMIA open. 2021 Jul 1;4(3):ooab083. [Google Scholar] [Crossref]

14. Climent MT, Pardo J, Muñoz-Almaraz FJ, Guerrero MD, Moreno L. Decision tree for early detection of cognitive impairment by community pharmacists. Frontiers in Pharmacology. 2018 Oct 29;9:1232. [Google Scholar] [Crossref]

15. Beede E, Baylor E, Hersch F, Iurchenko A, Wilcox L, Ruamviboonsuk P, Vardoulakis LM. A human-centered evaluation of a deep learning system deployed in clinics for the detection of diabetic retinopathy. InProceedings of the 2020 CHI conference on human factors in computing systems 2020 Apr 21 (pp. 1-12). [Google Scholar] [Crossref]

16. Chen ZH, Lin L, Wu CF, Li CF, Xu RH, Sun Y. Artificial intelligence for assisting cancer diagnosis and treatment in the era of precision medicine. Cancer Commun (Lond) 2021 Nov;41(11):1100-1115 [Google Scholar] [Crossref]

17. Grzybowski A, Brona P, Lim G, Ruamviboonsuk P, Tan G, Abramoff M, et al. Artificial intelligence for diabetic retinopathy screening: a review. Eye (Lond) 2020 Mar;34(3):451-460 [Google Scholar] [Crossref]

18. Ozsahin I, Sekeroglu B, Musa MS, Mustapha MT, Uzun Ozsahin D. Review on diagnosis of COVID-19 from chest CT images using artificial intelligence. Comput Math Methods Med 2020 Sep 26;2020:9756518 [Google Scholar] [Crossref]

19. Jessica H, Britney R, Sarira ED, Parisa A, Joe Z. Applications of artificial intelligence in current pharmacy practice: A scoping review. Research in Social and Administrative Pharmacy. 2024 Dec 17. [Google Scholar] [Crossref]

20. Hidalgo CA, Orghian D, Canals JA, De Almeida F, Martin N. How humans judge machines. MIT Press; 2021 Feb 2. [Google Scholar] [Crossref]

21. Tanguay-Sela M, Benrimoh D, Popescu C, Perez T, Rollins C, Snook E, Lundrigan E, Armstrong C, Perlman K, Fratila R, Mehltretter J. Evaluating the perceived utility of an artificial intelligence-powered clinical decision support system for depression treatment using a simulation center. Psychiatry research. 2022 Feb 1;308:114336. [Google Scholar] [Crossref]

22. Wang D, Wang L, Zhang Z, Wang D, Zhu H, Gao Y, Fan X, Tian F. “Brilliant AI doctor” in rural clinics: challenges in AI-powered clinical decision support system deployment. InProceedings of the [Google Scholar] [Crossref]

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