AI-Driven Optimization of Healthcare Supply Chains: From Prediction to Real-Time Response

Authors

Geraldine I. Ifeanyi

Department of Nursing, Ursuline College, Pepperpike, Ohio (USA)

Peacemark Hammed

SHRIDEapp limited, Ibadan (Nigeria)

Article Information

DOI: 10.51244/IJRSI.2026.1305000192

Subject Category: Computer Science

Volume/Issue: 13/5 | Page No: 2116-2123

Publication Timeline

Submitted: 2026-04-28

Accepted: 2026-05-03

Published: 2026-06-09

Abstract

Healthcare supply chains operate at the intersection of clinical care, logistics, and public health, where efficiency is not merely a matter of cost but of life and survival. Over the past decade, increasing demand variability, globalization of pharmaceutical production, and rising complexity in healthcare delivery have exposed structural weaknesses in traditional supply chain systems. These systems have historically relied on linear forecasting methods, siloed data environments, and delayed decision-making processes, which are inadequate in addressing rapidly evolving healthcare needs. This review synthesizes existing scholarly literature on AI-driven optimization in healthcare supply chains, with particular emphasis on the continuum from predictive analytics to real-time operational intelligence. The paper further explores how AI technologies such as machine learning, deep learning, and IoT-enabled systems enhance forecasting accuracy, improve inventory management, and enable dynamic logistics optimization. Additionally, it examines the implications of these advancements for global health systems, especially in the context of pandemic preparedness and equitable access to healthcare resources. The review concludes by identifying key challenges, including data fragmentation, ethical concerns, and implementation barriers, while proposing future directions for research and practice.

Keywords

AI; Optimization; Healthcare; Supply Chain; Prediction; Real-Time Response

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References

1. Dobrzykowski D. Understanding the downstream healthcare supply chain: unpacking regulatory and industry characteristics. Journal of Supply Chain Management. 2019 Apr;55(2):26-46. [Google Scholar] [Crossref]

2. Mathur B, Gupta S, Meena ML, Dangayach GS. Healthcare supply chain management: literature review and some issues. Journal of Advances in Management Research. 2018 Jul 25;15(3):265-87. [Google Scholar] [Crossref]

3. Govindan K, Mina H, Alavi B. A decision support system for demand management in healthcare supply chains considering the epidemic outbreaks: A case study of coronavirus disease 2019 (COVID-19). Transportation research part e: logistics and transportation review. 2020 Jun 1;138:101967. [Google Scholar] [Crossref]

4. Nelson ML, Sen R. Business rules management in healthcare: A lifecycle approach. Decision Support Systems. 2014 Jan 1;57:387-94. [Google Scholar] [Crossref]

5. Bam L, McLaren ZM, Coetzee E, Von Leipzig KH. Reducing stock-outs of essential tuberculosis medicines: a system dynamics modelling approach to supply chain management. Health Policy and Planning. 2017 Oct 1;32(8):1127-34. [Google Scholar] [Crossref]

6. Karamshetty V, De Vries H, Van Wassenhove LN, Dewilde S, Minnaard W, Ongarora D, Abuga K, Yadav P. Inventory management practices in private healthcare facilities in Nairobi county. Production and Operations Management. 2022 Feb;31(2):828-46. [Google Scholar] [Crossref]

7. Saddikuti V, Prakash S, Siddharth V, Jain K, Satpathy S. A prescription for efficiency: optimizing the surgical item inventory management practices in a healthcare facility. Journal of Advances in Management Research. 2024 Jul 4;21(3):478-506. [Google Scholar] [Crossref]

8. Singh H. Artificial intelligence for predictive analytics: Gaining actionable insights for better decision-making. International Journal of Research in Electronics and Computer Engineering. 2019;8(1). [Google Scholar] [Crossref]

9. Selvarajan GP. Harnessing AI-Driven Data Mining for Predictive Insights: A Framework for Enhancing Decision-Making in Dynamic Data Environments. International Journal of Creative Research Thoughts. 2021 Jun;9(2):5476-86. [Google Scholar] [Crossref]

10. Gereffi G. What does the COVID-19 pandemic teach us about global value chains? The case of medical supplies. Journal of International Business Policy. 2020 Jul 15;3(3):287. [Google Scholar] [Crossref]

11. Mekonen ZT, Fenta TG, Nadeem SP, Cho DJ. Global health commodities supply chain in the era of COVID-19 pandemic: challenges, impacts, and prospects: a systematic review. Journal of Multidisciplinary Healthcare. 2024 Dec 31:1523-39. [Google Scholar] [Crossref]

12. Bhaskar S, Tan J, Bogers ML, Minssen T, Badaruddin H, Israeli-Korn S, Chesbrough H. At the epicenter of COVID-19–the tragic failure of the global supply chain for medical supplies. Frontiers in public health. 2020 Nov 24;8:562882. [Google Scholar] [Crossref]

13. Kumar KP, Swarubini PJ, Ganapathy N. Cognitive artificial intelligence. InArtificial intelligence and biological sciences 2025 Mar (pp. 301-323). CRC Press. [Google Scholar] [Crossref]

14. Siemens G, Marmolejo-Ramos F, Gabriel F, Medeiros K, Marrone R, Joksimovic S, De Laat M. Human and artificial cognition. Computers and Education: Artificial Intelligence. 2022 Jan 1;3:100107. [Google Scholar] [Crossref]

15. Zohdi M, Rafiee M, Kayvanfar V, Salamiraad A. Demand forecasting based machine learning algorithms on customer information: an applied approach. International Journal of Information Technology. 2022 Jun;14(4):1937-47. [Google Scholar] [Crossref]

16. Carbonneau R, Laframboise K, Vahidov R. Application of machine learning techniques for supply chain demand forecasting. European journal of operational research. 2008 Feb 1;184(3):1140-54. [Google Scholar] [Crossref]

17. Usmani UA, Happonen A, Watada J. A review of unsupervised machine learning frameworks for anomaly detection in industrial applications. InScience and information conference 2022 Jul 7 (pp. 158-189). Cham: Springer International Publishing. [Google Scholar] [Crossref]

18. Choi WH, Kim J. Unsupervised learning approach for anomaly detection in industrial control systems. Applied System Innovation. 2024 Feb 21;7(2):18. [Google Scholar] [Crossref]

19. Meyer G, Adomavicius G, Johnson PE, Elidrisi M, Rush WA, Sperl-Hillen JM, O'Connor PJ. A machine learning approach to improving dynamic decision making. Information systems research. 2014 Jun;25(2):239-63. [Google Scholar] [Crossref]

20. Padakandla S. A survey of reinforcement learning algorithms for dynamically varying environments. ACM Computing Surveys (CSUR). 2021 Jul 13;54(6):1-25. [Google Scholar] [Crossref]

21. Mishra S. A reinforcement learning approach for training complex decision making models. International Journal of Artificial Intelligence, Data Science, and Machine Learning. 2022 Oct 30; [Google Scholar] [Crossref]

22. 3(3):82-92. [Google Scholar] [Crossref]

23. Akande SA, Enyejo JO. Leveraging predictive analytics to improve demand forecasting and inventory management in healthcare supply chains. International Journal of Scientific Research in Science, Engineering and Technology. 2024 Mar;11(2). [Google Scholar] [Crossref]

24. Oluwole O, Emmanuel E, Ogbuagu OO, Alemede V, Adefolaju I. Pharmaceutical supply chain optimization through predictive analytics and value-based healthcare economics frameworks. International Journal of Engineering Technology Research & Management. 2024;8(2):88-104. [Google Scholar] [Crossref]

25. Inam SA. A review of artificial intelligence for predicting climate driven infectious disease outbreaks to enhance global health resilience. Discover Public Health. 2025 Nov 23;22(1):738. [Google Scholar] [Crossref]

26. Ekundayo F. Using machine learning to predict disease outbreaks and enhance public health surveillance. World J Adv Res Rev. 2024;24(3):794-811. [Google Scholar] [Crossref]

27. Ogwu MC, Izah SC. Technologies for predictive modeling of tropical diseases. InTechnological Innovations for Managing Tropical Diseases 2025 Feb 20 (pp. 109-130). Cham: Springer Nature Switzerland. [Google Scholar] [Crossref]

28. Adegoke BO, Odugbose T, Adeyemi C. Data analytics for predicting disease outbreaks: A review of models and tools. International journal of life science research updates [online]. 2024;2(2):1-9. [Google Scholar] [Crossref]

29. Desai AN, Kraemer MU, Bhatia S, Cori A, Nouvellet P, Herringer M, Cohn EL, Carrion M, Brownstein JS, Madoff LC, Lassmann B. Real-time epidemic forecasting: challenges and opportunities. Health security. 2019 Aug 1;17(4):268-75. [Google Scholar] [Crossref]

30. Modupe OT, Otitoola AA, Oladapo OJ, Abiona OO, Oyeniran OC, Adewusi AO, Komolafe AM, Obijuru A. Reviewing the transformational impact of edge computing on real-time data processing and analytics. Computer Science & IT Research Journal. 2024 Mar;5(3):693-702. [Google Scholar] [Crossref]

31. Ficili I, Giacobbe M, Tricomi G, Puliafito A. From sensors to data intelligence: Leveraging IoT, cloud, and edge computing with AI. Sensors. 2025 Mar 12;25(6):1763. [Google Scholar] [Crossref]

32. Gudala L, Shaik M, Venkataramanan S, Sadhu AK. Leveraging artificial intelligence for enhanced threat detection, response, and anomaly identification in resource-constrained iot networks. Distributed Learning and Broad Applications in Scientific Research. 2019 Jul 5;5:23-54. [Google Scholar] [Crossref]

33. Ghouri A. Real Time Data Analytics with AI: Improving Security Event Monitoring and Management. Unique Journal of Artificial Intelligence. 2026 Jan 16;4(1):99-110. [Google Scholar] [Crossref]

34. Subramanian L. Effective demand forecasting in health supply chains: emerging trend, enablers, and blockers. Logistics. 2021 Feb 28;5(1):12. [Google Scholar] [Crossref]

35. Islam S, Habib MM. Integrating forecasting & planning management for sustainable hospital supply chains and societal advancement. International Journal of Supply Chain Management. 2024;12(4):34-41. [Google Scholar] [Crossref]

36. Niaz M, Nwagwu U. Managing healthcare product demand effectively in the post-COVID-19 environment: Navigating demand variability and forecasting complexities. American Journal of Economic and Management Business (AJEMB). 2023 Sep 26;2(8):316-30. [Google Scholar] [Crossref]

37. Tadayonrad Y, Ndiaye AB. A new key performance indicator model for demand forecasting in inventory management considering supply chain reliability and seasonality. Supply chain analytics. 2023 Sep 1;3:100026. [Google Scholar] [Crossref]

38. Niaz M, Nwagwu U. Managing healthcare product demand effectively in the post-COVID-19 environment: Navigating demand variability and forecasting complexities. American Journal of Economic and Management Business (AJEMB). 2023 Sep 26;2(8):316-30.\ [Google Scholar] [Crossref]

39. Levine R, Pickett J, Sekhri N, Yadav P. Demand forecasting for essential medical technologies. American journal of law & medicine. 2008 Jun;34(2-3):225-55. [Google Scholar] [Crossref]

40. Khan MI, Lama R, Islam KS, Karim MR, Tamang B. AI-Driven Risk Management & Optimization in Healthcare Supply Chain: A Machine Learning Approach. Journal of Artificial Intelligence General science (JAIGS) ISSN: 3006-4023. 2025;8(02):149-60. [Google Scholar] [Crossref]

41. Kumar V, Goodarzian F, Ghasemi P, Chan FT, Gupta N. Artificial intelligence applications in healthcare supply chain networks under disaster conditions. International Journal of Production Research. 2025 Jan 17;63(2):395-403. [Google Scholar] [Crossref]

42. Krykavskyy Y, Shandrivska O, Pawłyszyn I. A study of macroeconomic and geopolitical influences and security risks in supply chains in times of disruptions. LogForum. 2023;19(3). [Google Scholar] [Crossref]

43. Byrapu SR. Supply chain risk management. J. Algebr. Stat. 2023 Jan 30;14:150-5. [Google Scholar] [Crossref]

44. Giudici P, Centurelli M, Turchetta S. Artificial Intelligence risk measurement. Expert Systems with Applications. 2024 Jan 1;235:121220. [Google Scholar] [Crossref]

45. Tian T, Jia S, Lin J, Huang Z, Wang KO, Tang Y. Enhancing industrial management through AI integration: A comprehensive review of risk assessment, machine learning applications, and data-driven strategies. Economics & Management Information. 2024 Nov 11:1-8. [Google Scholar] [Crossref]

46. Chowdhury AR. A systematic review of risk-based procurement strategies in retail supply chains: Sourcing flexibility and vendor disruption management. American Journal of Advanced Technology and Engineering Solutions. 2025 Apr 17;1(01):466-505. [Google Scholar] [Crossref]

47. Goldschmidt K, Kremer M, Thomas DJ, Craighead CW. Strategic sourcing under severe disruption risk: Learning failures and under-diversification bias. Manufacturing & Service Operations Management. 2021 Jul;23(4):761-80. [Google Scholar] [Crossref]

48. Yoon J, Talluri S, Yildiz H, Ho W. Models for supplier selection and risk mitigation: a holistic approach. International journal of production research. 2018 May 19;56(10):3636-61. [Google Scholar] [Crossref]

49. Leaven L, Ahmmad K, Peebles D. Inventory management applications for healthcare supply chains. International Journal of Supply Chain Management. 2017 Sep 30;6(3):1-7. [Google Scholar] [Crossref]

50. Essila JC. Strategies for reducing healthcare supply chain inventory costs. Benchmarking: An International Journal. 2023 Nov 22;30(8):2655-69. [Google Scholar] [Crossref]

51. Azizi S, Yoltay DN, Kundakcioglu OE. Inventory Management for Medical Supplies. InEncyclopedia of Optimization 2024 May 24 (pp. 1-10). Cham: Springer Nature Switzerland. [Google Scholar] [Crossref]

52. Farooq A, Abbey AB, Onukwulu EC. Inventory optimization and sustainability in retail: A conceptual approach to data-driven resource management. International Journal of Multidisciplinary Research and Growth Evaluation. 2024 Nov;5(6):1356-63. [Google Scholar] [Crossref]

53. Amosu OR, Kumar P, Ogunsuji YM, Oni S, Faworaja O. AI-driven demand forecasting: Enhancing inventory management and customer satisfaction. World Journal of Advanced Research and Reviews. 2024 Aug 8;23(2):100-10. [Google Scholar] [Crossref]

54. Nweje U, Taiwo M. Leveraging Artificial Intelligence for predictive supply chain management, focus on how AI-driven tools are revolutionizing demand forecasting and inventory optimization. International Journal of Science and Research Archive. 2025 Jan 30;14(1):230-50. [Google Scholar] [Crossref]

55. Sajja GS, Addula SR, Meesala MK, Ravipati P. Optimizing inventory management through AI-driven demand forecasting for improved supply chain responsiveness and accuracy. InAIP conference proceedings 2025 Jun 5 (Vol. 3306, No. 1, p. 050003). AIP Publishing LLC. [Google Scholar] [Crossref]

56. da Costa TP, Gillespie J, Cama-Moncunill X, Ward S, Condell J, Ramanathan R, Murphy F. A systematic review of real-time monitoring technologies and its potential application to reduce food loss and waste: Key elements of food supply chains and IoT technologies. Sustainability. 2022 Dec 29;15(1):614. [Google Scholar] [Crossref]

57. Bhutta MN, Ahmad M. Secure identification, traceability and real-time tracking of agricultural food supply during transportation using internet of things. Ieee Access. 2021 Apr 28;9:65660-75. [Google Scholar] [Crossref]

58. Tsang YP, Choy KL, Wu CH, Ho GT, Lam CH, Koo PS. An Internet of Things (IoT)-based risk monitoring system for managing cold supply chain risks. Industrial Management & Data Systems. 2018 Sep 28;118(7):1432-62. [Google Scholar] [Crossref]

59. Pajic V, Andrejic M, Chatterjee P. Enhancing cold chain logistics: A framework for advanced temperature monitoring in transportation and storage. Mechatron. Intell Transp. Syst. 2024 Jan;3(1):16-30. [Google Scholar] [Crossref]

60. Müller WA, Ferreira SB, Botelho da Silva S. Enhancing food safety in the cold chain through internet of things and artificial intelligence. Journal of Food Science. 2026 Feb;91(2):e70871. [Google Scholar] [Crossref]

61. Ageron B, Benzidia S, Bourlakis M. Healthcare logistics and supply chain–issues and future challenges. InSupply Chain Forum: An International Journal 2018 Jan 2 (Vol. 19, No. 1, pp. 1-3). Taylor & Francis. [Google Scholar] [Crossref]

62. Veluru CS. A comprehensive study on optimizing delivery routes through generative AI using real-time traffic and environmental data. Journal of Scientific and Engineering Research. 2023;10(10):168-75. [Google Scholar] [Crossref]

63. Mohsen BM. AI-driven optimization of urban logistics in smart cities: Integrating autonomous vehicles and IoT for efficient delivery systems. Sustainability. 2024 Dec 22;16(24):11265. [Google Scholar] [Crossref]

64. Hussain KM. Revolutionizing Route Optimization Systems with Artificial Intelligence for a Smarter, Sustainable Logistics Ecosystem. International Journal of Computer Science and Mobile Computing. 2025 Feb;14(2). [Google Scholar] [Crossref]

65. Créput JC, Hajjam A, Koukam A, Kuhn O. Dynamic vehicle routing problem for medical emergency management. Self organizing maps-applications and novel algorithm design. 2011 Jan 21:233-50. [Google Scholar] [Crossref]

66. Yazdani M, Shahriari S, Haghani M. Real-time decision support model for logistics of emergency patient transfers from hospitals via an integrated optimisation and machine learning approach. Progress in Disaster Science. 2025 Jan 1;25:100397. [Google Scholar] [Crossref]

67. Mills AF, Argon NT, Ziya S. Dynamic distribution of patients to medical facilities in the aftermath of a disaster. Operations Research. 2018 Jun;66(3):716-32. [Google Scholar] [Crossref]

68. Baurasien BK, Alareefi HS, Almutairi DB, Alanazi MM, Alhasson AH, Alshahrani AD, Almansour SA, Alshagag ZA, Alqattan KM, Alotaibi HM. Medical errors and patient safety: Strategies for reducing errors using artificial intelligence. International journal of health sciences. 2023 Jan;7(S1):3471-87. [Google Scholar] [Crossref]

69. Verma A, Singhal N. Integrating artificial intelligence for adaptive Decision-Making in complex system. InInternational Conference on Advances in Data-driven Computing and Intelligent Systems 2023 Sep 21 (pp. 95-105). Singapore: Springer Nature Singapore. [Google Scholar] [Crossref]

70. Bhavikatta NB. AI-Driven inventory optimization in supply chains: A comprehensive review on reducing stockouts and mitigating overstock risks. Journal of Computer Science and Technology Studies. 2025 Jun 30;7(7):01-13. [Google Scholar] [Crossref]

71. Devabhaktuni R. Trustworthy AI Framework for Intelligent Warehouse Automation and Predictive Inventory Management. International Journal of Artificial Intelligence and Expert Systems (IJAE). 2025 Dec 1;14(3):50-62. [Google Scholar] [Crossref]

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