Formulation and Evaluation of Taste Masked Oral Disintegrating Films of Tolterodine Tartarate
Authors
Faculty Department of Pharmaceutics, Netaji Institute of Pharmaceutical Sciences, Hanamkonda, Warangal Telangana State (India)
Department of Pharmaceutics, Vaagdevi Institute of Pharmaceutical Sciences affiliated by Kakatiya University, Telangana, Warangal 506001 (India)
Department of Pharmacognocy, Vaagdevi College of Pharmacy affiliated by Kakatiya University, Telangana, Warangal 506002 (India)
Department of Pharmaceutics, Vaagdevi College of Pharmacy affiliated by Kakatiya University, R & D head, magnificient cosmo cosmoceuticals, Telangana Warangal 506002 (India)
Article Information
DOI: 10.51244/IJRSI.2025.12120071
Subject Category: Health Science
Volume/Issue: 12/12 | Page No: 840-849
Publication Timeline
Submitted: 2025-12-25
Accepted: 2026-01-01
Published: 2026-01-06
Abstract
Tolterodine tartarate is a widely used antimuscarinic agent that is used in the treatment of urinary incontinence. This study includes the formulation and evaluation of Oral Disintegrating Films of Tolterodine tartarate, which helps in obtaining the better dissolution rate, quick onset of action and improving the patient compliance. Tolterodine ODF were prepared by solvent casting method using water soluble polymers like HPMC E15, HPMC 5cps and HPMC 50cps in different ratios. These prepared films were evaluated for in-vitro disintegration time, film thickness, drug content, in-vitro drug release etc. Based on the results, the formulation containing HPMC E15 in 1:5 ratio was found to be as the best formulation. The in-vitro disintegration time was 20.02+0.32 sec and a drug release was found to be 99.61+ 0.23 % in 15 minutes.
Keywords
HPMC, Oral disintegrating films, Tolterodine.
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References
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