Prevalence of Hepatitis C Virus and Related Transmission Factors among Pregnant Women Attending Antenatal Clinic in Dar Es Salaam, Tanzania.

Authors

Shadrack Mayaga Luhunga

Faculty of Postgraduate and Research, Department of Public Health, Kampala International University in Tanzania (KIUT), P.O. Box 9790, Dar es Salaam (Tanzania)

Dr. A. B. Kalolella

Faculty of Postgraduate and Research, Department of Public Health, Kampala International University in Tanzania (KIUT), P.O. Box 9790, Dar es Salaam (Tanzania)

Dr. L. Mwanyika

Faculty of Postgraduate and Research, Department of Public Health, Kampala International University in Tanzania (KIUT), P.O. Box 9790, Dar es Salaam (Tanzania)

Dr. Janeth Emilly Mtebe

Faculty of Postgraduate and Research, Department of Public Health, Kampala International University in Tanzania (KIUT), P.O. Box 9790, Dar es Salaam (Tanzania)

Article Information

DOI: 10.51244/IJRSI.2025.12120086

Subject Category: Public Health

Volume/Issue: 12/12 | Page No: 1000-1010

Publication Timeline

Submitted: 2025-12-25

Accepted: 2026-01-01

Published: 2026-01-12

Abstract

Hepatitis C Virus (HCV) remains a significant global public health challenge, with approximately 58 million individuals infected and around 1.5 million new cases reported annually. This study focused on evaluating HCV prevalence and identifying factors associated with its transmission among pregnant women attending antenatal care (ANC) services in Dar es Salaam, Tanzania. The main objectives were to assess the prevalence of HCV and determine contributing factors. A cross-sectional design with a quantitative approach was used, targeting pregnant women visiting ANC clinics. A sample size of 471 participants was established through convenience sampling, with data collected via structured questionnaires and biological samples. The results indicated that a prevalence rate of HVC in Dar es Salaam Region was 1.7%. This low prevalence was linked to limited awareness, particularly among those engaging in risky behaviors like participated in unprotected sexual activities, shared sharp objects, or had a history of injection drug use were at a higher risk of HCV transmission. The study suggests that the Tanzanian government enhance awareness campaigns to educate both women and men in the community about HCV.

Keywords

Hepatitis C Virus (HCV), Vertical Transmission

Downloads

References

1. Akunna, G. G., & Lucyann, C. A. (2023). Nigeria’s War Against Drug Abuse: Prevalence, Patterns, Ramifications, Policy and Multisectoral Response, Strategies and Solutions. Studies in Social Science & Humanities, 2(10), 35-55. [Google Scholar] [Crossref]

2. Alenzi, M., & Almeqdadi, M. (2024). Bridging the gap: Addressing disparities in hepatitis C screening, access to care, and treatment outcomes. World Journal of Hepatology, 16(8), 1091. [Google Scholar] [Crossref]

3. Aremu, D. O., Maxim, A., Aremu, S. O., Aremu, D. E., Terhemen, Y. D., Itodo, S. O., & Barkhadle, A. A. (2025). The interplay of socio-demographic factors and disease prevalence: insights into malaria, Hepatitis B, and Hepatitis C in Lafia, Nasarawa State, Nigeria. Journal of Health, Population and Nutrition, 44(1), 67. [Google Scholar] [Crossref]

4. Asgedom, Y. S., Kassie, G. A., Woldegeorgis, B. Z., Meskele Koyira, M., & Kebede, T. M. (2024). Seroprevalence of hepatitis B virus infection and factors associated among pregnant women in Ethiopia: A systematic review and meta-analysis. Women's Health, 20, 17455057241235881. [Google Scholar] [Crossref]

5. Crequit, S., Chatzistergiou, K., Bierry, G., Bouali, S., La Tour, A. D., Sgihouar, N., & Renevier, B. (2023). Association between social vulnerability profiles, prenatal care use and pregnancy outcomes. BMC pregnancy and childbirth, 23(1), 465. [Google Scholar] [Crossref]

6. Dirisu, O., Adediran, M., Omole, A., Akinola, A., Ebenso, B., Shoyemi, E., ... & Adebajo, S. (2022). The syndemic of substance use, high-risk sexual behavior, and violence: a qualitative exploration of the intersections and implications for HIV/STI prevention among key populations in Lagos, Nigeria. Frontiers in tropical diseases, 3, 822566. [Google Scholar] [Crossref]

7. Eleje, G. U., Usman, H. A., Onubogu, C. U., Fiebai, P. O., Akaba, G. O., Rabiu, A., ... & Ikechebelu, J. I. (2025). Seroprevalence, seroconversion, and mother-to-child transmission of dual and triplex infections of HIV, HBV, and HCV among Nigerian obstetric population: A national multicentre prospective cohort study. Antiviral Therapy, 30(2), 13596535251333259. [Google Scholar] [Crossref]

8. Gyunda, D. J. (2023). Seroprevalence, Clinical Patterns and Factors Associated with Hepatitis B and C Virus Infections Among Patients With Chronic Liver Diseases in Dodoma Region, Tanzania (Master's thesis, University of Dodoma (Tanzania)). [Google Scholar] [Crossref]

9. Hokororo, J. C., Habtu, M., Bahegwa, R. P., Ngowi, R. R., Msigwa, Y. S., Degeh, M. M., ... & Eliakimu, E. S. (2022). Patient Safety Efforts in Tanzania: A Rapid Review of Two-Decades Efforts (2002-2022) to Inform Interventions towards Attainment of 2030 Targets. Advances in Infectious Diseases, 12(3), 466495. [Google Scholar] [Crossref]

10. Jiyenze, M. K., Tundui, C., & Mollel, H. (2022). Practices Of Implementing And Monitoring The Progress Of Health Sector Strategic Plan: The Perspectives Of The Council Health Managers In Tanzania. East African Medical Journal, 99(10). [Google Scholar] [Crossref]

11. Kondili, L. A., Quaranta, M. G., & Andreoni, M. (2025). Bridging the gap: advancing health equity and eliminating HBV and HCV among marginalized populations. The Lancet Regional Health–Europe, 49. [Google Scholar] [Crossref]

12. Larebo, Y. M., Anshebo, A. A., Abdo, R. A., Behera, S. K., & Gopalan, N. (2024). Prevalence of hepatitis B virus infection among pregnant women in Africa: A systematic review and meta-analysis. Plos one, 19(7), e0305838. [Google Scholar] [Crossref]

13. Lemoine, M., Eholié, S., & Lacombe, K. (2015). Reducing the neglected burden of viral hepatitis in Africa: strategies for a global approach. Journal of hepatology, 62(2), 469-476. [Google Scholar] [Crossref]

14. Leone, S., Sudan, S., & East, M. (2024). Democratic Republic of Congo. Chad, Haiti and Mali. [Google Scholar] [Crossref]

15. Makokha, G. N., Bao, H., Hayes, C. N., Abuduwaili, M., Songok, E., Hijikata, M., & Chayama, K. (2024). The prevalence and genotype distribution of hepatitis C virus in kenya: A systematic review and MetaAnalysis. Journal of Epidemiology and Global Health, 14(3), 677-689. [Google Scholar] [Crossref]

16. Moshabela, M., Bukenya, D., Darong, G., Wamoyi, J., McLean, E., Skovdal, M., ... & Wringe, A. (2017). Traditional healers, faith healers and medical practitioners: the contribution of medical pluralism to bottlenecks along the cascade of care for HIV/AIDS in Eastern and Southern Africa. Sexually transmitted infections, 93(Suppl 3). [Google Scholar] [Crossref]

17. Nguyen, N. T. H., Hoai, L. N., Bui, L. T. M., Chang, Y. M., Abdi, A. A., Hsu, S. C., ... & Huang, C. C. (2024). [Google Scholar] [Crossref]

18. Global mortality of chronic liver diseases attributable to Hepatitis B virus and Hepatitis C virus infections from 1990 to 2019 and projections to 2030. Journal of Infection and Public Health, 17, 102443. [Google Scholar] [Crossref]

19. Okonko, I. O., & Shaibu, N. (2023). Evidence of HIV/HCV Coinfection Among People Living With HIV/AIDS Attending Federal Medical Centre, Yenagoa, Nigeria. medRxiv, 2023-03. [Google Scholar] [Crossref]

20. Remera, E., Tuyishime, E., Kayitesi, C., Malamba, S. S., Sangwayire, B., Umutesi, J., ... & Oluoch, T. (2024). HIV and hepatitis B, C co-infection and correlates of HIV infection among men who have sex with men in Rwanda, 2021: a respondent-driven sampling, cross-sectional study. BMC Infectious Diseases, 24(1), 347. [Google Scholar] [Crossref]

21. Roudot-Thoraval, F. (2021). Epidemiology of hepatitis C virus infection. Clinics and research in hepatology and gastroenterology, 45(3), 101596. [Google Scholar] [Crossref]

22. Rugakingira, A. A., Yondu, E., Thobias, J. M., Dionis, I., Kamata, C. C., Kilonzi, M., ... & Sirili, N. (2024). Opportunities and challenges for the integration of managing non-communicable diseases within HIV care and treatment services in Tanzania. HIV Research & Clinical Practice, 25(1), 2398869. [Google Scholar] [Crossref]

23. Shah, R., Agyei-Nkansah, A., Alikah, F., Asamoah-Akuoko, L., Bagou, Y. C. O., Dhiblawe, A., ... & Thomson, E. C. (2021). Hepatitis C virus in sub-Saharan Africa: a long road to elimination. The Lancet Gastroenterology & Hepatology, 6(9), 693-694. [Google Scholar] [Crossref]

24. Sheehan, Y., Cochrane, A., Treloar, C., Grebely, J., Tedla, N., Lloyd, A. R., & Lafferty, L. (2024). [Google Scholar] [Crossref]

25. Understanding hepatitis C virus (HCV) health literacy and educational needs among people in prison to enhance HCV care in prisons. International Journal of Drug Policy, 130, 104516. [Google Scholar] [Crossref]

26. Stroffolini, T., & Stroffolini, G. (2024). Prevalence and modes of transmission of hepatitis C virus infection: A historical worldwide review. Viruses, 16(7), 1115. [Google Scholar] [Crossref]

27. Tesfu, M. A., Belay, N. B., & Habtemariam, T. T. (2022). Co-infection of HIV or HCV among HBsAg positive delivering mothers and its associated factors in governmental hospitals in Addis Ababa, Ethiopia: a cross-sectional study. Plos one, 17(8), e0273300. [Google Scholar] [Crossref]

28. Toma, D., Anghel, L., Patraș, D., & Ciubară, A. (2025). Hepatitis C Virus: Epidemiological Challenges and Global Strategies for Elimination. Viruses, 17(8), 1069. [Google Scholar] [Crossref]

29. Torre, P., Festa, M., Sarcina, T., Masarone, M., & Persico, M. (2024). Elimination of HCV infection: Recent epidemiological findings, barriers, and strategies for the coming years. Viruses, 16(11), 1792. [Google Scholar] [Crossref]

30. Venkatesh, R., Huang, A. S., Gurmessa, K., & Hsu, E. B. (2024, December). Understanding Barriers to Hepatitis C Antiviral Treatment in Low–Middle-Income Countries. In Healthcare (Vol. 13, No. 1, p. 43). MDPI. [Google Scholar] [Crossref]

31. Wang, X., Liu, J., Wu, Y., Su, B., Chen, M., Ma, Q., ... & Ma, J. (2023). Enhancing the effectiveness of infectious disease health education for children and adolescents in China: a national multicenter schoolbased trial. BMC Public Health, 23(1), 1161. [Google Scholar] [Crossref]

32. World Health Organization. (2022). Global health sector strategies on, respectively, HIV, viral hepatitis and sexually transmitted infections for the period 2022-2030. World Health Organization. [Google Scholar] [Crossref]

33. Wu, S., Wang, J., Guo, Q., Lan, H., Sun, Y., Ren, M., ... & Li, G. (2023). Prevalence of human immunodeficiency virus, syphilis, and hepatitis B and C virus infections in pregnant women: a systematic review and meta-analysis. Clinical microbiology and infection, 29(8), 1000-1007. [Google Scholar] [Crossref]

Metrics

Views & Downloads

Similar Articles