Pharmacological Evaluation of Imperata Cylindrica Crude Extract as Anti-Angiogenic Potential: Network Pharmacology, Molecular Docking Prediction with ADMET Analysis and CAM Assay Visualization

Authors

Sheemaiah Kylle L. Hasim

STEM Department, Carlos P. Garcia Senior High School, Davao City (Philippines)

Mary Chris M. Castillo

STEM Department, Carlos P. Garcia Senior High School, Davao City (Philippines)

Riza Jane T. Andig

STEM Department, Carlos P. Garcia Senior High School, Davao City (Philippines)

Julio Raymundo M. Pasagui

STEM Department, Carlos P. Garcia Senior High School, Davao City (Philippines)

Judie L. Velasco

STEM Department, Carlos P. Garcia Senior High School, Davao City (Philippines)

Article Information

DOI: 10.51244/IJRSI.2026.13020055

Subject Category: Technology

Volume/Issue: 13/2 | Page No: 616-648

Publication Timeline

Submitted: 2026-02-13

Accepted: 2026-02-18

Published: 2026-02-28

Abstract

This study investigated the anti-angiogenic potential of Imperata cylindrica (cogon grass) leaf extract through an integrated network pharmacology–guided in silico approach coupled with in vivo validation, focusing on the multi-target behavior of its bioactive compounds. Given the central role of angiogenesis in tumor growth and metastasis, identifying plant-derived compounds capable of modulating angiogenic pathways remains a strategic priority in cancer research.

Keywords

Imperata cylindrica, angiogenesis, bioactive compounds

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