A Review on Role of Siddha Medicine in Improving CD4 Cells in HIV Patients

Siddha medicine, one of the most ancient traditional systems of medicine originating from South India, emphasizes holistic health, immunity enhancement, and disease prevention. In the context of Human Immunodeficiency Virus (HIV) infection, depletion of CD4 T-lymphocytes remains a major concern as it leads to progressive immunodeficiency. While modern antiretroviral therapy (ART) effectively suppresses viral replication, immune restoration may be slow and incomplete in some patients. Siddha medicine offers supportive and complementary approaches aimed at improving immune strength, enhancing quality of life, and supporting CD4 cell regeneration. This review elaborates on the theoretical concepts of Siddha medicine, the role of immunity (Uyir Thathukkal and Udalthathukkal), and the importance of specific Siddha formulations such as Nilavembu Kudineer, Thiripala Chooranam, and Aya Birungaraja Karpam in maintaining and improving CD4 cell counts in HIV patients.

CD4 cells, Nilavembu Kudineer, Thiripala Chooranam

1. Thilagavathi R, Mahadevan MH, Eswaran C, Vanmathi KP. A case study on management of HIV by integrated treatment with Siddha medicine and ART. J Res Siddha Med. 2018;1(1):59–62. [Google Scholar] [Crossref]

2. Kuppusamyumudhaliyar KN, Uththamarayan KS. Siddha Vaidhyathiratu (1st ed). Chennai: Indian Medicine and Homeopathy Department; 1998; p.232,294. [Google Scholar] [Crossref]

3. Venugopal PM. Udalthaththuvam (3rd ed). Chennai: Indian Medicine and Homeopathy department; 1993; p.169,250 [Google Scholar] [Crossref]

4. Thiyagarajan R. Sidhhamaruthuvam Sirappu (2nd ed). Chennai: The Directorate of Indian medicine and Homeopathy; 1995; p.3,4,23. [Google Scholar] [Crossref]

5. P. Parthiban, V. Kumar Siddha medicine and clinical presentation of dengue fever at tertiary care hospital of Chennai, Tamil Nadu, India. [Google Scholar] [Crossref]

6. Nagalingam V, Varnakulendran N, Elango V. Detection of bioactive compound of Ayabirungaraja karpam by GC-MS analysis. [Google Scholar] [Crossref]

7. Thiyagarajan R. Sidhhamaruthuvam Sirappu (2nd ed). Chennai: The Directorate of Indian medicine and Homeopathy; 1995; p.3,4,23. [Google Scholar] [Crossref]

• Artificial Intelligence in Pharmacology, Drug Safety and Toxicity
• Seroprevalence and Associated Risk Factors of Treponema Pallidum Infection among Pregnant Women Attending Antenatal Clinics in Lokoja, Kogi State
• In Silico Evaluation of Hyptis Verticillata-Derived Phytochemicals Targeting Estrogen Receptor Alpha (Erα) and Progesterone Receptor in Hormone-Dependent Breast Cancer
• A Review Article on AI in Personalized Medicine & Novel Pharamacology
• Leech Therapy (Hirudotherapy): A Comprehensive Systematic Review of Pharmacological Constituents, Mechanisms of Action, Therapeutic Applications, and Safety