In Silico Study of Diuretic by Using the Flower of Aerva Lanata L

Authors

Haseena Parveen.N

Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore (India)

Dr. C. A. Annapoorani

Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore (India)

Article Information

DOI: 10.51244/IJRSI.2025.1208004123

Subject Category: Public Health

Volume/Issue: 12/9 | Page No: 4661-4678

Publication Timeline

Submitted: 2025-10-07

Accepted: 2025-10-15

Published: 2025-10-24

Abstract

Diuretics are medications commonly used to treat conditions characterized by fluid retention, such as edema and hypertension. Diuretics promote increased urine production, which can help flush out toxins and potentially prevent the formation of kidney stones.This increased urine output can potentially help in flushing out small stones or reducing the concentration of stone-forming substances in the urine. The flower of Aerva lanataL has been studied for its potential therapeutic effects in the context of kidney stones and diuretic properties. It may possess anti-urolithic properties, which could be beneficial in preventing or treating kidney stones. Aervalanata flowers are known for their diuretic effects, meaning they can increase urine production. This property has been traditionally used to treat conditions associated with fluid retention and urinary problems. It exhibits anti-inflammatory properties, which can help reduce inflammation and associated symptoms in various conditions. Aervalanata has been investigated for its potential to prevent the formation of urinary stones (urolithiasis) due to its diuretic and urinary alkalizing propertiesand it also have antineoplastic activity.

Keywords

Kidney stone, Diuretics, Aerva lanata flower, Osteopontin, Biological activity, Antineoplastic, Anti-inflammatory.

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References

1. Bitasta, M., & Madan, S. (2016). Aervalanata: A blessing of mother nature. Journal of Pharmacognosy and Phytochemistry, 5(1), 92-101. [Google Scholar] [Crossref]

2. ParamasivamRagavendran,D.S., Raj,C.A., Starlin, T., & Gopalakrishnan, V. K. (2012). Phytochemical screening, antioxidant activity of Aervalanata (L)–An Invitro study. Asian Journal of Pharmaceutical and Clinical Research, 5(2), 77-81. [Google Scholar] [Crossref]

3. Narayanan, M., Krishnan, L., Natarajan, D., Kandasamy, S., El Askary, A., Elfasakhany, A., &Pugazhendhi, A. (2021). Evaluation of antibacterial, antioxidant, and nephroprotective proficiency of methanol extract of Aervalanata. Process Biochemistry, 109, 98-103. [Google Scholar] [Crossref]

4. Goyal M, Pareek A, Nagori BP, Sasmal D. Aervalanata: A review on phytochemistry and pharmacological aspects. Pharmacogn Rev. 2011 Jul;5(10):195-8. doi: 10.4103/0973-7847.91120. PMID: 22279378; PMCID: PMC3263055. [Google Scholar] [Crossref]

5. Dinnimath, B. M., Jalalpure, S. S., & Patil, U. K. (2017). Antiurolithiatic activity of natural constituents isolated from Aervalanata. Journal of Ayurveda and integrative medicine, 8(4), 226-232. [Google Scholar] [Crossref]

6. Athira, P., & Nair, S. N. (2017). Pharmacognostic review of medicinal plant Aervalanata. Journal of pharmaceutical sciences and Research, 9(9), 1420. [Google Scholar] [Crossref]

7. Sofia, N. H., Walter, T. M., & Sanatorium, T. (2016). Prevalence and risk factors of kidney stone. Global Journal for Research Analysis, 5(3), 183-7. [Google Scholar] [Crossref]

8. Alelign, T., & Petros, B. (2018). Kidney stone disease: an update on current concepts. Advances in urology, 2018. [Google Scholar] [Crossref]

9. Bird, V. Y., & Khan, S. R. (2017). How do stones form? Is unification of theories on stone formation possible? Archivosespanoles de urologia, 70(1), 12. [Google Scholar] [Crossref]

10. Alexander, R. T., Hemmelgarn, B. R., Wiebe, N., Bello, A., Morgan, C., Samuel, S., ... & Tonelli, M. (2012). Kidney stones and kidney function loss: a cohort study. Bmj, 345. [Google Scholar] [Crossref]

11. Mariswamy, Y., Gnanaraj, W. E., Antonisamy, J. M., Adaikalam, A. A., &Jamesraj, V. (2013). GC-MS studies on methanolic extracts of Aervalanata L. American Journal of Pharmaceutical Research, 3(3), 2687-2717 [Google Scholar] [Crossref]

12. Agarwal, S., & Mehrotra, R. J. J. C. (2016). An overview of molecular docking. JSM chem, 4(2), 1024-1028. [Google Scholar] [Crossref]

13. Chaudhary, K. K., & Mishra, N. (2016). A review on molecular docking: novel tool for drug discovery. Databases, 3(4), 1029. [Google Scholar] [Crossref]

14. Khan, S. R. (1997). Animal models of kidney stone formation: an analysis. World journal of urology, 15, 236-243. [Google Scholar] [Crossref]

15. Kayalvizhi, D., Sivakumar, V., & Jayanthi, M. (2015). Phytochemical screening and antinephrolithiasis activity of ethanol extract of Aervalanata on ethylene glycol induced renal stone in rats. Research Journal of Pharmacy and Technology, 8(11), 1481-1486. [Google Scholar] [Crossref]

16. Vishnupriya, S., &Tamilselvi, K. (2022). A study on phytochemical screening and antiurolithiatic activity of Aervalanata (L.) Juss. ex Schult. leaves extract. Asian J. Innov. Res, 6(1), 10-13. [Google Scholar] [Crossref]

17. Gomathi, D., Kalaiselvi, M., Ravikumar, G., Devaki, K., & Uma, C. (2015). GC-MS analysis of bioactive compounds from the whole plant ethanolic extract. Journal of food science and technology, 52, 1212-1217. [Google Scholar] [Crossref]

18. Thangavel, A., Balakrishnan, S., Arumugam, A., Duraisamy, S., & Muthusamy, S. (2014). Phytochemical screening, gas chromatography-mass spectrometry (GC-MS) analysis of phytochemical constituents and anti-bacterial activity of Aervalanata (L.) leaves. African journal of pharmacy and pharmacology, 8(5), 126-135. [Google Scholar] [Crossref]

19. Anandan, A., Eswaran, R., Doss, A., Sangeetha, G., & Anand, S. P. (2012). Investigation for bioactive compounds of Aervalanata (L.) Juss. ex Schultes. Asian Journal of Research in Chemistry, 5(4), 469-471. [Google Scholar] [Crossref]

20. Lagunin, A., Filimonov, D., &Poroikov, V. (2010). Multi-targeted natural products evaluation based on biological activity prediction with PASS. Current Pharmaceutical Design, 16(15), 1703-1717. [Google Scholar] [Crossref]

21. Poroikov, V. V., Filimonov, D. A., Ihlenfeldt, W. D., Gloriozova, T. A., Lagunin, A. A., Borodina, Y. V., ... & Nicklaus, M. C. (2003). PASS biological activity spectrum predictions in the enhanced open NCI database browser. Journal of Chemical Information and Computer Sciences, 43(1), 228-236. [Google Scholar] [Crossref]

22. Guedes, I. A., de Magalhães, C. S., & Dardenne, L. E. (2014). Receptor–ligand molecular docking. Biophysical reviews, 6, 75-87. [Google Scholar] [Crossref]

23. Gschwend, D. A., Good, A. C., & Kuntz, I. D. (1996). Molecular docking towards drug discovery. Journal of Molecular Recognition: An Interdisciplinary Journal, 9(2), 175-186. [Google Scholar] [Crossref]

24. Abdullabekova V.N., Khaydarov, V. R., Sharipova, S. T., Rakhimova, O. R. Q., &Tajieva, A. J. (2022). Using the method of mathematical planning of the experiment in the development of a quality control method of aervalanata l. herb. Cardiometry, (22), 108-117. [Google Scholar] [Crossref]

25. Al-Ansari, M., Al-Humaid, L. A., Vijayaraghavan, P., Ravindran, B., Chang, S. W., Agastian, P., ... &Balamuralikrishnan, B. (2019). Identification of phytochemical components from Aervalanata (Linn.) medicinal plants and its in-vitro inhibitory activity against drug resistant microbial pathogens and antioxidant properties. Saudi Journal of Biological Sciences, 26(6), 1129-1133. [Google Scholar] [Crossref]

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