Phytochemical Screening and Antioxidant Activity of Crinum jagus Bulb Aqueous Extract: A Potential Indicator for Anti-Convulsive Syncope Properties

Plants and their derivatives are essential to human and animal lives. They are used traditionally to treat various diseases. Crinum jagus (Amarylidaceae) plant is one of such plants. It is employed in the treatment of asthma, mental related illnesses, inflammation, diverse forms of convulsion etc. The most commonly used part of Crinum jagus plant for medicinal purposes is the bulb. Convulsive syncope is characterized by a sudden temporary loss of consciousness and involuntary muscle jerk due to reduced supply of oxygen to the brain. It is not the same as epilepsy, which normally occurs as a result of sudden electrical surge in the brain, but was reported to have cardivascular origin cause, and also leads to higher short-term mortality than epilepsy. This study screened Crinum jagus bulb crude aqueous extract for its phytochemicals namely alkaloids, saponnin, flavonoid, terpenoids, tannins, anthraquinones, phenols, steroids, cardiac glycosides, oxalates, and phytate; and also evaluated its antioxidant activity using different standard methods, in order to evaluate its anti-convulsive syncope potential as its being used locally. The results of the study revealed that Crinum jagus bulb is very rich in phenolic compounds, total flavonoids, cardiac glycosides and tannins. The terpenoids, oxalates, steroids, alkaloids, saponins, anthroquinone, and phytates were also present in appreciable proportion needed to support its anti-convulsive syncope property. The extract also displayed significant antioxidant activity in each of the different methods used, which also compliments its potential as an anti-convulsive syncope agent. Thus, Crinum jagus bulb crude aqueous extract could be developed into a potent anti-convulsive syncope agent that will be cheaper and readily available for the masses.

Crinum jagus bulb, Phytochemicals, Antioxidants, Convulsive Syncope.

1. Abubakar D. U. and Wakili, F. (2017). Phytochemical Screening and Elemental Analysis of the Crinum Jagus bulb. J. Chem. Soc. Nigeria, 42(2):53-55 [Google Scholar] [Crossref]

2. Acampora, R., Marte, G., Scala, R., Lieto, M., Maida, P., & Mazzaferro, M. P. (2021). Recurrent convulsive syncope misdiagnosed as seizures due to a diaphragmatic hernia. Neurological Sciences, 42(11), 4727-4729. [Google Scholar] [Crossref]

3. Ahmed, M. B., Islam, S. U., Alghamdi, A. A., Kamran, M., Ahsan, H., and Lee, Y. S. (2022). Phytochemicals as chemo-preventive agents and signaling molecule modulators: current role in cancer therapeutics and inflammation. International Journal of Molecular Sciences, 23(24), 15765. [Google Scholar] [Crossref]

4. Akinyele, S. T., Elusiyan, C. A., Omisore, N. O., and Adewunmi, C. O. (2022). Antimalarial activities and alkaloids from Crinum jagus (Thomps) Dandy. Journal of Ethnopharmacology, 296, 115359. [Google Scholar] [Crossref]

5. Akuru U.B. and Amadi B.A. (2018). Phytochemicals and Antioxidant Properties of Some Selected Medicinal Plants. Journal of Pharmacognosy and Phytochemistry, 7(5): 283-285 [Google Scholar] [Crossref]

6. Alawode, T. T. (2024). Phytochemical, Proximate and Mineral Analysis of Leaves and Bulb of Crinum jagus. International Journal of Basic Science and Technology, 10(3):283 – 291. [Google Scholar] [Crossref]

7. Alawode, T. T., Lajide, L., Owolabi, B. J., and Olaleye, M. T. (2021). Investigation of Bulb Extracts of Crinum jagus for Antibacterial and Antifungal Activities. Journal of Applied Sciences and Environmental Management, 25(1), 113-117. [Google Scholar] [Crossref]

8. Aliyu, I. M. A., Magaji, M. G., Yau, J., and Muhammed, D. N. (2025). Ethnobotanical survey of medicinal plants used in the management of asthma in North-Western Nigeria. Journal of Medicinal Plants Research, 19(6):85-91. [Google Scholar] [Crossref]

9. Al-Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T., Field, M. E., Fonarow, G. C., Gillis, A. M., Granger, C. B., Hammill, S. C., Hlatky, M. A., Joglar, J. A., Kay, G. N., Matlock, D. D., Myerburg, R. J., and Page, R. L. (2018). 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Circulation, 138(13), e210–e271. [Google Scholar] [Crossref]

10. Al-Khayri, J. M., Sahana, G. R., Nagella, P., Joseph, B. V., Alessa, F. M., and Al-Mssallem, M. Q. (2022). Flavonoids as potential anti-inflammatory molecules: A review. Molecules, 27(9):2901. [Google Scholar] [Crossref]

11. Amakor, A., and Shagal, M. H. Exploring the Antivenom Potentials of Crinum Jagus Bulbs in the Treatment of Snake Bite from Girei, Adamawa State, Nigeria. International Journal of Reseach and Scientific Innovation, XI (VII):790-794. [Google Scholar] [Crossref]

12. Anderson, J. L., and Morrow, D. A. (2017). Acute Myocardial Infarction. The New England journal of medicine, 376(21), 2053–2064. [Google Scholar] [Crossref]

13. Aryal, B., Raut, B. K., Bhattarai, S., Bhandari, S., Tandan, P., Gyawali, K., Sharma, K., Ranabhat, D., Thapa, R., Aryal, D., Ojha, A., Devkota, H. P., and Parajuli, N. (2022). Potential Therapeutic Applications of Plant-Derived Alkaloids against Inflammatory and Neurodegenerative Diseases. Evidence-based complementary and alternative medicine, 2022(1):7299778. [Google Scholar] [Crossref]

14. Atunwa, S. A. (2023). Evaluation of the neurocognitive and neuroprotective potentials of selected Nigerian medicinal plants in experimental models of dementia. Alzheimer's Dementia, 19: e080714. [Google Scholar] [Crossref]

15. Babakr A. T. (2025). Oxidized low-density lipoproteins and their contribution to atherosclerosis. Exploration of Cardiology, 3:101246. [Google Scholar] [Crossref]

16. Behnoush, A. H., Yazdani, K., Khalaji, A., Tavolinejad, H., Aminorroaya, A., Jalali, A., and Tajdini, M. (2023). Pharmacologic prevention of recurrent vasovagal syncope: A systematic review and network meta-analysis of randomized controlled trials. Heart Rhythm, 20(3), 448-460. [Google Scholar] [Crossref]

17. Bergfeldt, L. (2003). Differential diagnosis of cardiogenic syncope and seizure disorders. Heart, 89(3): 353-358. [Google Scholar] [Crossref]

18. Botts, S. R., Fish, J. E., and Howe, K. L. (2021). Dysfunctional vascular endothelium as a driver of atherosclerosis: emerging insights into pathogenesis and treatment. Frontiers in pharmacology, 12:3787. [Google Scholar] [Crossref]

19. Cañas, S., Rebollo-Hernanz, M., Bermúdez-Gómez, P., Rodríguez-Rodríguez, P., Braojos, C., Gil-Ramírez, A., and Martín-Cabrejas, M. A. (2023). Radical scavenging and cellular antioxidant activity of the cocoa shell phenolic compounds after simulated digestion. Antioxidants, 12(5):1007. [Google Scholar] [Crossref]

20. Chandimali, N., Bak, S. G., Park, E. H., Lim, H. J., Won, Y. S., Kim, E. K., and Lee, S. J. (2025). Free radicals and their impact on health and antioxidant defenses: A review. Cell death discovery, 11(1):19. [Google Scholar] [Crossref]

21. Chen, J. and Mehta, J. L. (2006). Interaction of oxidized low-density lipoprotein and the renin-angiotensin system in coronary artery disease. Current hypertension reports, 8(2):13. [Google Scholar] [Crossref]

22. Chiarioni, G., Popa, S. L., Ismaiel, A., Pop, C., Dumitrascu, D. I., Brata, V. D., and Surdea-Blaga, T. (2023). Herbal remedies for constipation-predominant irritable bowel syndrome: a systematic review of randomized controlled trials. Nutrients, 15(19):4216. [Google Scholar] [Crossref]

23. Cirillo C, and Capasso R. (2015) Constipation and botanical medicines: an overview. Phytotherapy Research 29(10):1488-1493. [Google Scholar] [Crossref]

24. Crivelli, J. J., Mitchell, T., Knight, J., Wood, K. D., Assimos, D. G., Holmes, R. P., and Fargue, S. (2020). Contribution of dietary oxalate and oxalate precursors to urinary oxalate excretion. Nutrients, 13(1):62. [Google Scholar] [Crossref]

25. D’Amelia, V., Aversano, R., Chiaiese, P., Carputo, D. (2018). The antioxidant properties of plant flavonoids: Their exploitation by molecular plant breeding. Phytochem. Review, 17:611–625. [Google Scholar] [Crossref]

26. da Silva, J. F. P., da Silva, T. R. L. P., de Santana, A. L. F., Gomes-Copeland, K. K. P., Gomes, J. V. D., Estrada-Semprun, O. E., and Silveira, D. (2025). The underexplored chemical diversity and biological potential of Amaryllidaceae from Cerrado. Discover Plants, 2(1):240. [Google Scholar] [Crossref]

27. Dalen, J. E., Alpert, J. S., Goldberg, R. J., and Weinstein, R. S. (2014). The epidemic of the 20(th) century: coronary heart disease. The American journal of medicine, 127(9):807–812. [Google Scholar] [Crossref]

28. de Lima, E. P., Laurindo, L. F., Catharin, V. C. S., Direito, R., Tanaka, M., Jasmin Santos German, I., and Barbalho, S. M. (2025). Polyphenols, alkaloids, and terpenoids against neurodegeneration: Evaluating the neuroprotective effects of phytocompounds through a comprehensive review of the current evidence. Metabolites, 15(2):124. [Google Scholar] [Crossref]

29. Dias, M. C., Pinto, D. C., and Silva, A. M. (2021). Plant flavonoids: Chemical characteristics and biological activity. Molecules, 26(17):5377. [Google Scholar] [Crossref]

30. Dominic, P., Ahmad, J., Awwab, H., Bhuiyan, M. S., Kevil, C. G., Goeders, N. E., and Olshansky, B. (2022). Stimulant drugs of abuse and cardiac arrhythmias. Circulation: Arrhythmia and electrophysiology, 15(1): e010273. [Google Scholar] [Crossref]

31. Ejelonu, Oluwamodupe Cecilia; Elekofehinti, Olusola Olalekan; Adanlawo, and Isaac Gbadura (March 2017). "Tithonia diversifolia saponin-blood lipid interaction and its influence on immune system of normal wistar rats". Biomedicine and Pharmacotherapy. 87:589–595. [Google Scholar] [Crossref]

32. Ekramzadeh, M., Moore, L. W., Kalantar-Zadeh, K., and Kopple, J. D. (2023). Phytate and kidney health: the roles of dietary phytate in inhibiting intestinal phosphorus absorption and Intravenous phytate in decreasing soft tissue calcification. Journal of Renal Nutrition, 33(2):225-227. [Google Scholar] [Crossref]

33. Enas M M. and Christa E M. (2016). Anthraquinones as Pharmacological Tools and Drugs. Med Res Rev 36(4):705-48. [Google Scholar] [Crossref]

34. Ermer, T., Nazzal, L., Tio, M. C., Waikar, S., Aronson, P. S., and Knauf, F. (2023). Oxalate homeostasis. Nature Reviews Nephrology, 19(2):123-138. [Google Scholar] [Crossref]

35. Flevari P, Livanis E.G, Theodorakis G.N, Zarvalis E, Mesiskli T, and Kremastinos D T H ( 2002). Vasovagal syncope. A prospective, randomized, crossover evaluation of the effect of propranolol, nadolol and placebo on syncope recurrence and patient's well-being. Journal of the American College of Cardiology; 40:499– 504. [Google Scholar] [Crossref]

36. Gbadamosi A. S. Oseni M.O. and Oseni O.A. (2024). Phytochemical Analysis, Antioxidant Properties, Anti-nutrient Contents and Antimicrobial Study of Aqueous Extract of Morinda lucinda, Solanum erianthun, and Dryopteris expansa. Asian Plant Research Journal, 12(5): 56-66. [Google Scholar] [Crossref]

37. Gbolade, A. A. (2020). Nigerian medicinal plants with anti-snake venom activity. A review. Journal of Malaria Research and Phytomedicine, 1(1):29-44. [Google Scholar] [Crossref]

38. Gharu, C. P. (2022). Defense mechanism of natural antioxidants against free radicals. Central Asian Journal of Medical and Natural Science, 3(5):163-170. [Google Scholar] [Crossref]

39. Gupta, N. S. (2024). Therapeutic Efficacy of the Plant Bioactive Phytochemicals with Special Reference to Alkaloids, Terpenoids, Phenolics and Cardiac Glycosides. International Journal of Plant and Environment, 10(01):22-30. [Google Scholar] [Crossref]

40. Halliwell, B. (2024). Understanding mechanisms of antioxidant action in health and disease. Nature Reviews Molecular Cell Biology, 25(1):13-33. [Google Scholar] [Crossref]

41. Hennissen, L., Bakker, M. J., Banaschewski, T., Carucci, S., Coghill, D., Danckaerts, M. and Adduce Consortium. (2017). Cardiovascular effects of stimulant and non-stimulant medication for children and adolescents with ADHD: a systematic review and meta-analysis of trials of methylphenidate, amphetamines and atomoxetine. CNS drugs, 31:199-215. [Google Scholar] [Crossref]

42. Ibrahim Sani et a (2020). Scholars International Journal of Traditional and Complementary Medicine, 3(6):111-117. [Google Scholar] [Crossref]

43. Igbari, A. D., Ejugwu, V. J., Nodza, G. I., and Ogundipe, O. T. (2023). Ethnobotanical survey and phytochemical screening of medicinal plants used in the management of asthma in Lagos Metropolis. Journal of Herbs, Spices and Medicinal Plants, 29(4):405-418. [Google Scholar] [Crossref]

44. Indermuehle, A., Crake, T. and Meier, P. (2011). Oxidized low-density lipoprotein cholesterol and coronary artery disease. Cardiology, 119 (2):106. [Google Scholar] [Crossref]

45. Inoue, T., Uchida, T., Kamishirado, H., Takayanagi, K., Hayashi, T. and Morooka, S. (2001). Clinical significance of antibody against oxidized low density lipoprotein in patients with atherosclerotic coronary artery disease. Journal of the American College of Cardiology, 37(3):775-779. [Google Scholar] [Crossref]

46. Jasia N., Tehmeena A., Naik H. R. and Hussain S.Z. (2017). A review phytic acid: As antinutrient or nutraceutical. Journal of Pharmacognosy and Phytochemistry, 6(6):1554-1560. [Google Scholar] [Crossref]

47. Jayawardena, T. U., Merindol, N., Liyanage, N. S., Gélinas, S. E., Lionel, B., Seydou, K. and Desgagné-Penix, I. (2025). Antiviral alkaloids from Crinum jagus: Extraction, synergistic effects, and activity against dengue virus and human coronavirus OC43. Heliyon, 11(4): e42580. [Google Scholar] [Crossref]

48. Kabir, S., Ogwuche, C. E., Tijjani, A., Gafar, M. K., Shah, S. A. A., and Mzozoyana, V. (2025). Phytochemical Pro-filing and Identification of Bioactive Phyto-Compounds Present in the Rhizome of Crinum Jagus. Journal of Molecular Genetics and Gene Research, 1(1):01-07. [Google Scholar] [Crossref]

49. Kanjwal, K., Karabin, B., Kanjwal, Y., and Grubb, B. P. (2009). Differentiation of convulsive syncope from epilepsy with an implantable loop recorder. International journal of medical sciences, 6(6), 296. [Google Scholar] [Crossref]

50. Katoch, R., Sanadya, S. K., Pathania, K., and Chaudhary, H. K. (2023). Nutritional and nutraceutical potential of rice bean (Vigna umbellata)–a legume with hidden potential. Frontiers in Nutrition, 10: 1126544. [Google Scholar] [Crossref]

51. Kokorelis, C., and Rowe, P. C. (2025). Seizure Versus Convulsive Syncope: A Case Report. Clinical pediatrics, 64(2):161-164. [Google Scholar] [Crossref]

52. Li, J., Lin, S., Vanhoutte, P. M., Woo, C. W., and Xu, A. (2016). Akkermansia muciniphila protects against atherosclerosis by preventing metabolic endotoxemia-induced inflammation in Apoe−/− mice. Circulation, 133(24):2434-2446. [Google Scholar] [Crossref]

53. Liu, Y., Lu, S., Meng, J., Xiang, H., Korma, S. A., Cacciotti, I., and Cui, C. (2023). Complexation between egg yolk protein hydrolysate, phytic acid and calcium ion: Binding mechanisms and influence on protein digestibility and calcium uptake. Lwt, 184: 114986. [Google Scholar] [Crossref]

54. Ma, Q., Wang, C. Z., Sawadogo, W. R., Bian, Z. X., and Yuan, C. S. (2022). Herbal medicines for constipation and phytochemical comparison of active components. The American Journal of Chinese Medicine, 50(03):723-732. [Google Scholar] [Crossref]

55. Maleki, S.J., Crespo, J.F. and Cabanillas, B. (2019).Anti-inflammatory effects of flavonoids. Food Chem. 299: 125124. [Google Scholar] [Crossref]

56. Mariama Salihu, Gaber El-Saber Batiha, Keneth Iceland Kasozi, George D. Zouganelis, Souty M.Z. Sharkawi, Eman Ibrahim Ahmed, Ibe Michael Usman, Halima Nalugo, Juma J. Ochieng, Ibrahim Ssengendo, Olatayo Segun Okeniran, Theophilus Pius, Kyobe Ronald Kimanje, Eric Simidi Kegoye, Ritah Kenganzi and Fred Ssempijja (2022). Crinum jagus (J. Thomps. Dandy): Antioxidant and protective properties as a medicinal plant on toluene-induced oxidative stress damages in liver and kidney of rats, Toxicology Reports, 9: 699-712. [Google Scholar] [Crossref]

57. Micek, A., Godos, J., Del Rio, D., Galvano, F., and Grosso, G. (2021). Dietary flavonoids and cardiovascular disease: a comprehensive dose–response meta‐analysis. Molecular nutrition and food research, 65(6):2001019. [Google Scholar] [Crossref]

58. Minkah, P. A. B., and Danquah, C. A. (2021). Anti-infective, anti-inflammatory and antipyretic activities of the bulb extracts of Crinum jagus (J. Thomps.) Dandy (Amaryllidaceae). Scientific African, 12:e00723. [Google Scholar] [Crossref]

59. Mitchell, T., Kumar, P., Reddy, T., Wood, K. D., Knight, J., Assimos, D. G., and Holmes, R. P. (2019). Dietary oxalate and kidney stone formation. American Journal of Physiology-Renal Physiology, 316(3):F409-F413. [Google Scholar] [Crossref]

60. Mvongo C., P. A Noubissi, R. Kamyang, C. S. Minka, A. Mfopa, S.B Abhijit and Y. M. Ramkrishna (2015). Phytochemical analysis, antioxidant potential of two different extract of crinum anti antibacterial properties of some selected Indian jagus. Int. J. Pharm. Sci. Res., 6(5): 2354-2359. [Google Scholar] [Crossref]

61. Nida T. K. (2019) Anthraquinones-A Naturopathic Compound. Journal of New Developments in Chemistry, 2(2):25-28. [Google Scholar] [Crossref]

62. Ode O. J, Nwaehujor C. O. and Onakpa M.M. (2010): Evaluation of anti-hemorrhagic and antioxidant potentials of Crinum jagus bulbs. International Journal of Applied Biology and Pharmaceutical Technology, 1(3):1330–1336. [Google Scholar] [Crossref]

63. Opiyo, S. A., and Njoroge, P. W. (2024). Plant extracts and terpenes with antivenom properties. IOSR Journal of Applied Chemistry, 17(3)1:31-41. [Google Scholar] [Crossref]

64. Otitolaiye, C., Omonkhua, A., Oriakhi, K., Okello, E., Onoagbe, I., and Okonofua, F. (2023). Phytochemical Analysis and in vitro Antioxidant Potential of Aqueous and Ethanol Extracts of Irvingia gabonensis Stem Bark. Pharmacognosy Research, 15(2): 363-372. [Google Scholar] [Crossref]

65. Parmenter, B. H., Croft, K. D., Hodgson, J. M., Dalgaard, F., Bondonno, C. P., Lewis, J. R., and Bondonno, N. P. (2020). An overview and update on the epidemiology of flavonoid intake and cardiovascular disease risk. Food and function, 11(8): 6777-6806. [Google Scholar] [Crossref]

66. Patel S (2016). "Plant-derived cardiac glycosides: Role in heart ailments and cancer management". Biomedicine & Pharmacotherapy. 84:1036–1041. [Google Scholar] [Crossref]

67. Ponce, A., Flores-Maldonado, C., and Contreras, R. G. (2025). Cardiac Glycosides: From Natural Defense Molecules to Emerging Therapeutic Agents. Biomolecules, 15(6):885. [Google Scholar] [Crossref]

68. Prajapati, M., Jayswal, S., and Maitreya, B. (2019). Phytochemical screening and comparative study of antioxidant activity of Cuminum cyminum L. and Nigella sativa L. Int J Basic Appl Res, 9:1305-15. [Google Scholar] [Crossref]

69. Rajput, A., Sharma, R., and Bharti, R. (2022). Pharmacological activities and toxicities of alkaloids on human health. Materials Today: Proceedings, 48:1407-1415. [Google Scholar] [Crossref]

70. Rakha, A., Umar, N., Rabail, R., Butt, M. S., Kieliszek, M., Hassoun, A.,and Aadil, R. M. (2022). Anti-inflammatory and anti-allergic potential of dietary flavonoids: A review. Biomedicine and Pharmacotherapy, 156:113945. [Google Scholar] [Crossref]

71. Ralapanawa, U., and Sivakanesan, R. (2021). Epidemiology and the Magnitude of Coronary Artery Disease and Acute Coronary Syndrome: A Narrative Review. Journal of epidemiology and global health, 11(2):169–177. [Google Scholar] [Crossref]

72. Ramatsobane Maureen Mangoale and Anthony Jide Afolayan (2020). Comparative Phytochemical Constituents and AntioxidantActivity of Wild and Cultivated Alepidea amatymbica Eckl and Zeyh. Hidawi Research International journal, 2020:13. [Google Scholar] [Crossref]

73. Ridwanto, R., Trizaldi, A., Rani, Z., Daulay, A. S., Nasution, H. M., and Miswanda, D. (2023). Antioxidant Activity Test of Methanol Extract of Gaharu (Aquilaria Malaccensis Lam.) Bark with DPPH (1, 1 Diphenyl-2-Picrylhydrazyl) Method. International Journal of Health and Pharmaceutical (IJHP), 3(2): 232-240. [Google Scholar] [Crossref]

74. Rojewska, M., Smułek, W., Grzywaczyk, A., Kaczorek, E., and Prochaska, K. (2023). Study of interactions between saponin biosurfactant and model biological membranes: phospholipid monolayers and liposomes. Molecules, 28(4):1965. [Google Scholar] [Crossref]

75. Roy, A. (2017). A review on the alkaloids an important therapeutic compound from plants. International Journal of Pharmaceutical Biotechnology, 3(2):1-9. [Google Scholar] [Crossref]

76. Šamec, D.; Karalija, E.; Šola, I.; Bok, V.V.; Salopek-Sondi, B. (2021).The role of polyphenols in abiotic stress response: The influence of molecular structure. Plants, 10:118. [Google Scholar] [Crossref]

77. Santos, T. C. D., Gomes, T. M., Pinto, B. A. S., Camara, A. L., and Paes, A. M. D. A. (2018). Naturally occurring acetylcholinesterase inhibitors and their potential use for Alzheimer's disease therapy. Frontiers in Pharmacology, 9:1192. [Google Scholar] [Crossref]

78. Scarabelli C.C. and Scarabelli T.M (2004). Convulsive syncope. British Medical Journal, 329: 336– 41. [Google Scholar] [Crossref]

79. Shan, K., Jiang, Q., Wang, X. Q., Wang, Y., Yang, H., Yao, M. D. and Yan, B. (2016). Role of long non-coding RNA-RNCR3 in atherosclerosis-related vascular dysfunction. Cell death and disease, 7(6): e2248-e2248. [Google Scholar] [Crossref]

80. Soker, E. B., Erdem, M., Ozdogru, D., Coddu, C., and Gulen, M. (2025). The Role of Serum Biomarkers in Differential Diagnosis of Epileptic Seizures, Functional/Cognitive Seizure and Syncope: A Cross-sectional Study. Clinical Neurology and Neurosurgery, 258:109123. [Google Scholar] [Crossref]

81. Udegbunam, S. O., Udegbunam, R. I., Nnaji, T. O., Anyanwu, M. U., Kene, R. O. C., and Anika, S. M. (2015). Antimicrobial and antioxidant effect of methanolic Crinum jagus bulb extract in wound healing. Journal of Intercultural Ethnopharmacology, 4(3):239. [Google Scholar] [Crossref]

82. Upadhyay, J., Tiwari, N., Durgapal, S., Jantwal, A., and Kumar, A. (2022). Phytic acid: As a natural antioxidant. In Antioxidants effects in health, Elsevier, page 437-450. [Google Scholar] [Crossref]

83. Xiao, M. Y., Li, S., Pei, W. J., Gu, Y. L., and Piao, X. L. (2025). Natural Saponins on Cholesterol‐Related Diseases: Treatment and Mechanism. Phytotherapy Research, 39(3):1292-1318. [Google Scholar] [Crossref]

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