Antiplasmodial and Toxicological Effects of Ethanolic Extracts of Mango (Mangiferaindica) Leaves and Bitter Cola (Garcinia kola) Seeds in Albino Rats
- August 21, 2019
- Posted by: RSIS
- Category: Health Sciences
International Journal of Research and Scientific Innovation (IJRSI) | Volume VI, Issue VIII, August 2019 | ISSN 2321–2705
Awoibi Kristhien1*, Amah H.2
1*Post Graduate Student Medical Laboratory Science, Faculty of Health Sciences, Imo State University Owerri Nigeria
2Lecturer Medical Laboratory Science, Faculty of Health Sciences, Imo State University Owerri Nigeria
Abstract: Malaria is one of the most important diseases in the world. The choice for the treatment is highly limited due to drug resistance. Hence, finding the new compounds to treat malaria is urgently needed. The present study aim at investigating the toxicological and anti-plasmodial effects of extracts of Mangiferaindica and Garcinia kola on Albino rat infected with Plasmodium berghei. For efficacy test in vivo, standard 5-day curative test was carried out. Rats were inoculated with 1×107/ml parasitized erythrocytes of Plasmodium berghei by intraperitoneal injection. The extracts (100,300, 500, 800, and 1000 mg/kg) of each plants were given separately to each group and orally once a day for 5 consecutive days. Average Percentage parasiemia and hemaological indices were estimated. Combisunate (10 mg/kg) was given to infected rats as reference control while untreated control was given only distilled water. It was found that ethanolic extracts of Mangiferaindica and Garcinia kola at different doses showed dose dependent parasitemia inhibitionbuthavenocurative effects. Therefore, Mangiferaindica and Garcinia kola exact significant anti-plasmodial activity and prolonged survival time with no toxicity.
Keywords: Toxicological, antiplasmodial, Mangiferaindica, Garcinia kola, Plasmodium berghei
I. INTRODUCTION
Plants provide nutrition for human based on their primary products of photosynthesis while the conventional pharmaceutical drugs, herbs, ethno medicines, essential oils and cosmetics are derived from secondary products of plants metabolism such as alkaloids, terpenoids and flavonoids [1]. These are the characteristics of medicinal plants, possession of pathological niche which revolved to a path genomic structure makes herbs being used for different ailments with respect to their actions/activities in the physiology of human.
