- February 25, 2022
- Posted by: RSIS
- Categories: Human Physiology, IJRSI
International Journal of Research and Scientific Innovation (IJRSI) | Volume IX, Issue I, January 2022 | ISSN 2321–2705
Njoku-Oji, Njideka Nancy1; Ifegwu, Njoku Oji2; Igbonaju, Marvelous3; Okwuonu, Ifeoma Frances4; Chukwukaeme, Chidinma Winifred5; Mmaju, Chidinma Ifeyinwa6; Okonudo, Peter Osezele7
1,3,4,5,6,7Department of Human Physiology, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
2Department of Anatomy, College of Medicine and Health Sciences, Abia State University Uturu, Abia State, Nigeria
*Corresponding Author: Ifegwu, Njoku Oji.
Abstract:- Objective: This study was carried out to investigate the effect of the ethanolic leaf extracts of Carica papaya (C. papaya) and Newbouldia laevis (N. laevis) on the lipid profile of alloxan-induced Wistar rats.
Methodology: Forty (40) male wistar rats weighing 130-150g were procured and acclimatized for two weeks, after which they were divided into eight (8) groups of five (5) rats each, and were housed in cages. The groups were designated as groups A, B, C, D, E, F, G and H. Groups B – H were induced with diabetes using alloxan. Group A served as the control group and received only distilled water; group B diabetic received only distilled water only, while groups C – H diabetic received 400mg/kg of C. papaya, 600mg/kg of C. papaya, 400mg/kg of N. laevis, 600mg/kg of N. laevis, 200mg/kg of C. papaya + 200mg/kg of N. laevis and 300mg/kg of C. papaya + 300mg/kg of N. laevis respectively for 21 days through oral route with the aid of oral gastric tube. On the 22nd day, the animals were sacrificed by chloroform inhalation, and blood samples were obtained through cardiac puncture for lipid profile parameters’ assays. Data obtained were analyzed using SPSS version 25 and (P<0.05) was considered significant.
Result: There was significant increase in the plasma total cholesterol, triglycerides, low density lipoprotein (LDL) with a decrease in plasma high density lipoprotein (HDL) of the animals in group B when compared with the control group. These effects were ameliorated in Groups C – H that received the variable doses of the ethanolic leaf extracts C. papaya and N. laevis with more positive effects on the groups that received the combined ethanolic leaf extracts.
Conclusion: The leaf extracts of C. papaya and N. laevis have ameliorative effects on the lipid profile alloxan-induced diabetic Wistar rats.
Keywords: Carica papaya, Newbouldia laevis, total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), high density lipoprotein (HDL)
