Effects of Hydromethanol Extracts of Garcinia Kola on Some Biochemical Parameters of Male Wistar Rats

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International Journal of Research and Scientific Innovation (IJRSI) | Volume VI, Issue XI, November 2019 | ISSN 2321–2705

Effects of Hydromethanol Extracts of Garcinia Kola on Some Biochemical Parameters of Male Wistar Rats

C. Obiandu1*; F. Saronee1; K. Okari2; and A.C. Obiandu3

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1Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Choba, Rivers State, Nigeria.
2Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Choba, Rivers State, Nigeria
3Post Primary Schools Board, Port Harcourt, Rivers State, Nigeria
*Corresponding Author

Abstract: Garcinia Kola is commonly used in traditional medicine for the treatment of diverse ailments including coronary artery diseases. Thus, this study aims to determine the effect of hydromethanol (1:4) extracts of the pulp and seed coat of Garcinia kola on serum lipid profile and its antioxidant properties. The two forms were separately dried and blended to powder. Forty male wistar rats (8 per group) were assigned into Five (5) groups. Groups were treated thus: Group one; control. Group two; 100mg/kg pulp extract. Group three; 200mg/kg pulp extract. Group four; 100mg/kg seed coat extract. Group five; 200mg/kg seed coat extract; for 30 and 60 days duration. On treatment conclusion, blood was collected for the determination of lipid profile and antioxidant properties. The higher dose of the pulp and seed coat extracts significantly (P˂0.05) increased the catalase level and superoxide dismutase enzyme activity, whereas, both the higher and lower doses of the seed coat extract caused a reduction in malondialdehyde level. The serum total cholesterol was significantly elevated by the higher dose of the pulp extract while the seed coat extract caused significantly increased high density lipoprotein cholesterol level and a reduction in the low density lipoprotein level. The two extracts demonstrated marked antioxidant effects. The seed coat of Garcinia kola may possess the potential to prevent cell death due to lipid peroxidation by inhibiting the lipid peroxidation process. The seed coat extract may also be useful in preventing coronary artery disease and other atherosclerotic problems.

Keywords: Garcinia kola, hydromethanol, wistar rats, antioxidant.

I. INTRODUCTION

Globally, there is increasing dependence on medicinal plants for the prevention and treatment of various illnesses [1]. Estimates, suggest that, a large number of the population of many developing countries heavily rely on medicinal plants and the services of traditional medicine practitioners to meet basic health care needs. It has been reported that 80% of the population in Africa depend on medicinal plants for primary health care [1][2][3]. The global importance attached to the use of medicinal plants is derived from its affordability, minimal side effects, and accessibility compared to modern medicines [1][2][3].