Histomophological Study of Aqueous Extract of Hibiscus Sabdariffa on Hormonally Induced Prostatic Enlargement of Adult Wistar Rat
- December 27, 2019
- Posted by: RSIS
- Categories: IJRSI, Medical Sciences
International Journal of Research and Scientific Innovation (IJRSI) | Volume VI, Issue XII, December 2019 | ISSN 2321–2705
S.O. Jimoh1, A.K Adefule1, O.J Ogundipe2, O.F. Akinpelu1, A.A. John-Caleb1, F.E. Oladipupo1, M.O Onasanya1
1Department of Anatomy, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ikenne Campus, Ogun State, Nigeria
2Department of physiological Sciences, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile – Ife, Osun State, Nigeria
Abstract: – Aim: to investigate some effects of aqueous extract of Hibiscus sabdariffa on induced benign prostatic hyperplasia. Material and Method: Forty eight male adult wistar rats weighing between 190g and 220g were used for the study. They were acclimatized for 2 weeks and fed with standard rat chow and water ad libitum before the study. They were divided into six groups. Group1- control group received 0.3ml of corn oil, others were induced for BPH with hormones (200µg Testosterone and 100µg estradiol) for 3 weeks; after induction Group 2 took distilled water, Group 3 received 0.71g of finasteride, Group 4, 5 and 6 received 0.3, 0.6 and 0.9g/kg bw Hibiscus sabdariffa (HS), respectively. The prostate were excised, processed and stained with H&E and Masson Trichrome. Result: The weight of group 4, 5 and 6 rats decrease compared to group 2 rats. There were pronounced reduction in the mucosal (epithelial) and fibromuscular stroma hyperplasia of the treated groups when compared with the group 2 rats. Conclusion: This indicates that the test herb has no adverse effect on prostatic parameters of healthy rats and also shows that Hibiscus sabdariffa extract can be viewed as a candidate novel medication for benign prostate hyperplasia therapy.
Key Words: Benign prostatic hyperplasia, finasteride, prostate gland, Hibiscus sabdariffa, Hormones
I. INTRODUCTION
The prostate is largest accessory gland of the male reproductive system. It lies in the lesser pelvis, just beneath the neck of the urinary bladder where urine is stored and behind the lower part of the pubic symphysis and upper part of the pubic arch. It is found in front of the ampulla of the rectum, above the urogenital diaphragm (2). The Prostate gland comprises of glandular part and fibro muscular part. A fibrous capsule envelopes the prostate which contains neurovascular plexus of veins and nerves, The prostate gland is a major secondary endocrine organ of males whose development and growth depends on androgen stimulation especially by dihydrotestosterone (DHT), an active metabolic product from the conversion of testosterone by steroid 5 “-reductase (28). The prostatic fluid is thin, slightly acidic (pH 6.4).
