Synthesis, Characterization and Antioxidant Properties of Metal (II) Complexes of Gallic Acid and Quercetin
- September 22, 2020
- Posted by: RSIS Team
- Categories: Chemistry, IJRIAS
International Journal of Research and Innovation in Applied Science (IJRIAS) | Volume V, Issue III, January 2020 | ISSN 2454–6186
Hassan B. Yesufu1, Salihu Alhaji Musa1, Garba T. Mohammed1, Mohammed B. Fugu2
1Department of Pharmaceutical Chemistry, University of Maiduguri, P.M.B 1069 Maiduguri, Nigeria
2Department of Chemistry, University of Maiduguri, P.M.B 1069 Maiduguri, Nigeria
Abstract :- The purpose of this study is to synthesized complexes of Mn and Zn with Quercetin and Gallic acid as ligands using reported procedure and characterized using IR, UV, AAS and Micro Analysis techniques. The purity of the complexes was monitored and analyze using TLC, Melting point, Conductivity measurement and Solubility test and the complexes were evaluated for antioxidant activity against 1,1-diphenylhydrazyl (DPPH) free radical. All the complexes are of good yield, colored, air stable, non hygroscopic, non electrolyte and partially soluble in organic solvent but soluble in DMF. The statistical analysis using one-way ANOVA show that all the complexes are strong free radical scavengers compares to the parent ligands at all the concentration tested but Zn complex at 6.25 µg/ml and 12.5 µg/ml showed better scavenging activity than the standard Ascorbic Acid (VIT. C). The EC50 regressional output shows that complex of Zn is found to be more portent than the other investigated compounds. On the basis of the above described studies an octahedral geometry has been proposed for the complexes.
Keywords: Quercetin, Gallic acid, Ascorbic Acid, DMF, Antioxidant, and Octahedral geometry.
