Lipid Profile of Alloxan-Induced Diabetic Albino Wistar Rats Pre-treated with Curcuma Longa Rhizome Powder, Crude Aqueous Extract and Both
- July 13, 2021
- Posted by: rsispostadmin
- Categories: Biochemistry, IJRIAS
International Journal of Research and Innovation in Applied Science (IJRIAS) | Volume VI, Issue VI, June 2021|ISSN 2454-6194
A.G. Oluwafemi1, O.B. Ajayi1, and O.A. Oseni2
1Department of Biochemistry, Ekiti State University, Ado Ekiti, Nigeria
2Department of Basic Medical Biochemistry, College of medicine, Ekiti State Nigeria
ABSTRACT
The pre-treatments with turmeric powder, extract and their mixture was evaluated in this paper to unriddle their effects on the lipid profile of diabetic rats after daily feeding and administration of the crude aqueous extract of turmeric rhizome powder for three weeks. A significantly (P≤ 0.05) decrease in weight and plasma level of High-Density Lipoprotein Cholesterol (HDL-C) were observed in alloxan-induced- diabetic rats in comparison with normal and pretreated groups. There was however a significant increase (P<0.05) in the blood glocuse level, plasma levels of total cholesterol, triglycerides, Low-Density Lipoprotein Cholesterol (LDL_C) of alloxan induced- diabetic rats (group B) when compared with normal (group A) and pre-treated groups (group C, D and E). The decrease in plasma triacylglycerol (TG) level, wheight gained and normal blood glucose levels observed in normal rats (group A) and pre-treated alloxan-induced diabetic rats in group E and others (C and D is an indication that turmeric rhizome in diet and as extract does not increase blood triglycerides. This suggests that it is unlikely to pose a health hazard as a high triglyceride level increases the risk of cardiovascular disease. The weight gained with normal blood glucose levels observed in group C, D and E might implies that pretraetment with turmeric powder or extract appears to be protective against pathological effects inflicted on alloxan induced-diabetic rats.
1.INTRODUCTION
Diabetes mellitus has been described as one of the major complex and chronic disorders of protein metabolism ,carbohydrate. It is usualllipid usually characterized by persistent elevation of blood glucose, resulting from a partial or complex cessation of insulin secretion , or peripheral resistance to insulin action (Longe et al., 2015). In recent literature, diabetics have been found to show abnormal lipid disorders such as hyperlipidemia, atherosclerosis (Asangaet al., 2013). Plasma lipids assayed for includes total cholesterol (TC), TG, LDL-C, and HDL-C. Lipid metabolism disorder has been found to be one of the reasons for premature atherosclerosis in patients with diabetes mellitus (Khanna et al., 1996).
Turmeric (Curcuma longa) , which belong to the family of ginger is a rhizomatous herbaceous perennial plant . It is called by different names in different cultures and widely cultivated in the tropics. In some states in Nigeria, like Ekiti, turmeric is commonly called “Osun” and “Ajo” in Ondo State. Furthermore, it is called “Hald” in North India, while in South, turmeric is known as “Manjal”. It is known as “terremerite” in French and simply as “yellow root” in many languages. In many cultures,
