Comparative Molecular Docking of Hyptis Verticillata Phytocompounds Against DNA Gyrase B and Multiple Bacterial Drug Targets

The rise of antimicrobial resistance (AMR) has become one of the most critical global health challenges, with multidrug-resistant bacteria severely reducing the efficacy of conventional antibiotics. According to the World Health Organization, resistant strains of Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli pose significant therapeutic challenges due to multiple resistance mechanisms, including efflux pump activation, enzymatic degradation, and mutation of drug targets (WHO, 2020). These limitations highlight the urgent need for alternative therapeutic strategies and novel bioactive scaffolds.

Hyptis verticillata; molecular docking; follicle-stimulating hormone receptor

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