A Hybrid Machine Learning Framework with Optimized Feature Selection for Augmenting Survival Prediction via Synthetic Match Generator

Authors

Padmini Kuppala

Department of CSE, Sreenidhi Institute of Science and Technology, Ghatkesar, Hyderabad (India)

Dr. Nilesh V. Ingale

Department of CSE, Vikrant University Gwalior (India)

Dr. V. Aruna

Department of CSE, Sreenidhi Institute of Science and Technology, Ghatkesar, Hyderabad (India)

Article Information

DOI: 10.47772/IJRISS.2026.1026EDU0131

Subject Category: Machine Learning

Volume/Issue: 10/26 | Page No: 1486-1494

Publication Timeline

Submitted: 2026-02-18

Accepted: 2026-02-24

Published: 2026-03-18

Abstract

Heart surgery is the most important thing that can be done for kids with end-stage heart failure, but there is still a big problem with death one year after the transplant. It is very important to get this mortality risk right in order to match donors and recipients more effectively and improve patient results. In this work, we use the ICU heart transplant expiration dataset to estimate the risk of death in pediatric heart transplant patients after one year. We suggest a new method that uses advanced feature selection and group methods to make predictions more accurate. Using Chi-squared tests to pick out key traits and combining multiple classifiers for accurate predictions are part of the method. The results show that the suggested Voting Classifier, which uses both Boosted Decision Tree and ExtraTree models, works very well, as it gets 100% of the votes right. This method is a quick and accurate way to guess the chance of death within a year. It gives doctors useful information for better patient care and finding the best match between recipient and donor in pediatric heart transplants.

Keywords

Machine learning algorithms, deep learning, classification

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References

1. A. Ashfaq, G. M. Gray, J. Carapellucci, E. K. Amankwah, L. M. Ahumada, M. Rehman, J. A. Quintessenza, and A. Asante-Korang, ‘‘Predicting one year mortality using machine learning after pediatric heart transplantation: Analysis of the united network of organ sharing (UNOS) database,’’ J. Heart Lung Transplantation, vol. 41, no. 4, p. S152, Apr. 2022. [Google Scholar] [Crossref]

2. A. E. Braat, J. J. Blok, H. Putter, R. Adam, A. K. Burroughs, A. O. Rahmel, R. J. Porte, X. Rogiers, and J. Ringers, ‘‘The eurotransplant donor risk index in liver transplantation: ET-DRI,’’ Amer. J. Transplantation, vol. 12, no. 10, pp. 2789–2796, Oct. 2012. [Google Scholar] [Crossref]

3. L. Breiman, ‘‘Random forests,’’ Mach. Learn., vol. 45, pp. 5–32, Oct. 2001. [Google Scholar] [Crossref]

4. J. Bullock, M. Grieco, Y. Liu, I. Pedersen, W. Roberson, G. Wright, P. Alonzi, M. A. McCulloch, and M. D. Porter, ‘‘Determining factors of heart quality and donor acceptance in pediatric heart transplants,’’ in Proc. Syst. Inf. Eng. Design Symp. (SIEDS), Apr. 2021, pp. 1–6. [Google Scholar] [Crossref]

5. [Online]. Available: http://optn.transplant.hrsa.gov [Google Scholar] [Crossref]

6. A. Chebli, A. Djebbar, and H. F. Marouani, ‘‘Semi-supervised learning for medical application: A survey,’’ in Proc. Int. Conf. Appl. Smart Syst. (ICASS), Nov. 2018, pp. 1–9. [Google Scholar] [Crossref]

7. M. Colvin, J. M. Smith, Y. Ahn, M. A. Skeans, E. Messick, K. Bradbrook, K. Gauntt, A. K. Israni, J. J. Snyder, and B. L. Kasiske, ‘‘OPTN/SRTR 2020 annual data report: Heart,’’ Amer. J. Transplantation, vol. 22, pp. 350–437, Mar. 2022. [Google Scholar] [Crossref]

8. A. I. Dipchand, ‘‘Current state of pediatric cardiac transplantation,’’ ASVIDE, vol. 5, pp. 1–116, Feb. 2018. [Google Scholar] [Crossref]

9. N. Gotlieb, A. Azhie, D. Sharma, A. Spann, N.-J. Suo, J. Tran, A. Orchanian-Cheff, B. Wang, A. Goldenberg, M. Chassé, H. Cardinal, J. P. Cohen, A. Lodi, M. Dieude, and M. Bhat, ‘‘The promise of machine learning applications in solid organ transplantation,’’ NPJ Digit. Med., vol. 5, no. 1, pp. 1–13, Jul. 2022. [Google Scholar] [Crossref]

10. C. Hyldahl, O. Kaczmarskyj, J. Laruffa, A. Miller, L. Snavely, A. Wan, and S. L. Riggs, ‘‘Designing a dashboard to streamline pediatric heart transplant decision making,’’ in Proc. Syst. Inf. Eng. Design Symp. (SIEDS), Apr. 2023, pp. 237–242. [Google Scholar] [Crossref]

11. J. M. G. Taylor, ‘‘Random survival forests,’’ J. Thoracic Oncol., vol. 6, no. 12, pp. 1974–1975, Dec. 2011. [Google Scholar] [Crossref]

12. M. O. Killian, S. Tian, A. Xing, D. Hughes, D. Gupta, X. Wang, and Z. He, ‘‘Prediction of outcomes after heart transplantation in pediatric patients using national registry data: Evaluation of machine learning approaches,’’ JMIR Cardio, vol. 7, Jun. 2023, Art. no. e45352. [Google Scholar] [Crossref]

13. J. K. Kirklin, D. C. Naftel, R. L. Kormos, L. W. Stevenson, F. D. Pagani, M. A. Miller, J. T. Baldwin, and J. B. Young, ‘‘The fourth INTERMACS annual report: 4,000 implants and counting,’’ J. Heart Lung Transplantation, vol. 31, no. 2, pp. 117–126, Feb. 2012. [Google Scholar] [Crossref]

14. S. M. Lundberg and S.-I. Lee, ‘‘A unified approach to interpreting model predictions,’’ in Proc. Adv. Neural Inf. Process. Syst., 2017, pp. 1–11. [Google Scholar] [Crossref]

15. R. Miller, D. Tumin, J. Cooper, D. Hayes, and J. D. Tobias, ‘‘Prediction of mortality following pediatric heart transplant using machine learning algorithms,’’ Pediatric Transplantation, vol. 23, no. 3, May 2019, Art. no. e13360. [Google Scholar] [Crossref]

16. R. J. H. Miller, F. Sabovč ik, N. Cauwenberghs, C. Vens, K. K. Khush, P. A. Heidenreich, F. Haddad, and T. Kuznetsova, ‘‘Temporal shift and predictive performance of machine learning for heart transplant outcomes,’’ J. Heart Lung Transplantation, vol. 41, no. 7, pp. 928–936, Jul. 2022. [Google Scholar] [Crossref]

17. V. Naruka, A. Arjomandi Rad, H. Subbiah Ponniah, J. Francis, R. Vardanyan, P. Tasoudis, D. E. Magouliotis, G. L. Lazopoulos, M. Y. Salmasi, and T. Athanasiou, ‘‘Machine learning and artificial intelligence in cardiac transplantation: A systematic review,’’ Artif. Organs, vol. 46, no. 9, pp. 1741–1753, Sep. 2022. [Google Scholar] [Crossref]

18. X. Yang, Z. Song, I. King, and Z. Xu, ‘‘A survey on deep semi-supervised learning,’’ IEEE Trans. Knowl. Data Eng., vol. 109, no. 2, pp. 1–20, Aug. 2022. [Google Scholar] [Crossref]

19. R. J. Williams, M. Lu, L. A. Sleeper, E. D. Blume, P. Esteso, F. Fynn-Thompson, C. J. Vanderpluym, S. Urbach, and K. P. Daly, ‘‘Pediatric heart transplant waiting times in the United States since the 2016 allocation policy change,’’ Amer. J. Transplantation, vol. 22, no. 3, pp. 833–842, Mar. 2022. [Google Scholar] [Crossref]

20. Porter, M. D., Sharff, J. R., Dixon, R., Haregu, F., & McCulloch, M. (2024). Using Machine Learning to Assess the Predictive Power of Donor Characteristics in Pediatric Heart Transplant Outcomes. The Journal of Heart and Lung Transplantation, 43(4), S622. [Google Scholar] [Crossref]

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