Evolution of Viral Lysis Techniques Post COVID-19: A Review of Some Major Advancements

Viral lysis is a critical step for obtaining nucleic acids and other components from viral particles. Prior to, and during the COVID-19 pandemic, viral lysis techniques required laboratory equipment and expertise, and especially required numerous washing steps post lysis for nucleic acid purification that significantly increase the overall turnaround time. Towards and during the Post COVID-19 era, novel and compelling lysis techniques revolutionised viral lysis. These innovations, born from the response to SARS-CoV-2, successfully overcame the numerous flaws of the ancient era, making viral lysis easier and safer to perform, less time consuming, cost-effective, and by far less demanding in terms of reagents, consumables, equipment, and expert personnel. This review presents and discusses some major advancements in viral lysis techniques in the post COVID-19 era. Emphasis is put on the innovation each technique brings and how it makes lysis better, safer and easier, and also how it shortens protocols and adaptability in point of care testing.

SARS-CoV-2 detection, Lysis techniques, Diagnostics, post COVID-19, Innovations

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