Morphological and Histochemical Investigation of the Role (S) of Moringa Oleifera (Lam) on 3-Nitropropionic Acid Model of Huntington’s disease
- November 20, 2020
- Posted by: RSIS Team
- Categories: Clinical Sciences, IJRSI
International Journal of Research and Scientific Innovation (IJRSI) | Volume VII, Issue XI, November 2020 | ISSN 2321–2705
O.F. Akinpelu1, P.D. Shalli2, O.J Ogundipe3*, F.E. Oladipupo4, S.O. Jimoh5, L.G Ogungbe6, O.M Onasanya7, O.A Alao8
1,2,4,5,7, Department of Anatomy, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ikenne Campus, Ogun State, Nigeria.
3 Department of physiological Sciences, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile – Ife, Osun State, Nigeria.
6Department of Anatomy, Faculty of Basic Medical Sciences, Lead city University Ibadan, Oyo State, Nigeria
8Department of Anatomy, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria
Corresponding Author*
ABSTRACT
Aim: This study evaluated the role of Moringe Oleifera (MO) in the treatment of Huntington’s disease induced by 3- Nitropropionic Acid (3-NP). Material and Method: Forty adult mice weighting between 25-32g were used and divided into four groups (A, B, C and D), Group A serves as the control (Received food and ad libitum), B (Received MO+3-NP), C (Received only 3-NP) and D (Received 3-NP + MO). 3- Nitropropionic Acid (20mg/kg) was administered to the animals intraperitoneal for 7 days. MO was administered orally (250mg/kg) for a period of 7 days. Weights of the animals were monitored periodically using the digital weighing balance. Animals were sacrificed at the end of the experiment and the brain tissue was excised for morphological and histochemical study.
Results showed cyto-architecture derangement of the brain tissue in the Huntington’s group, while the preventive group showed some degree of preservation of the tissue architecture. Conclusion: 3-Np induced huntington’s disease model in mice as expected with the characteristics of demyelination, chromatolysis, exaggerated protein clumps aggregations on the tissue organ and Moringa oleifera shows little curative effect on the neuronal neuro-degeneration.
Key word: huntington’s disease, 3-Nitropropionic acid, Moringa,
1.0 Introduction
Huntington’s disease (HD) is a genetic neurodegenerative disorder in which mental declination is observed and muscle coordination is impaired. It can also define as progressive neurodegenerative disorder associated with severe degeneration of basal ganglia neurons, (Freeman et al., 1993), especially the intrinsic neurons of the striatum, and characterized by progressive dementia and involuntary abnormal choreiform movements. As broad as knowledge is in the field of Nueroscience, there has been no cure available to completely cease or reverse the progressive neuro-degeneration and
