Synergistic Anthelmintic Activity of Leaf Extract of Andrographis Paniculata with other Plant Extracts
- September 10, 2020
- Posted by: RSIS Team
- Categories: Botany and Microbiology, IJRIAS
International Journal of Research and Innovation in Social Science (IJRISS) | Volume V, Issue IV, April 2020 | ISSN 2454–6186
Rajamanickam.V, Sivakumar.V
Arulmigu Kalasalingam College of Pharmacy, Krishnankoil, India
Abstract- The prevalence of worm infestation is high in underdeveloped and developing countries because of poor sanitation and lack of health education. Our study was aimed to search out the individual and synergestic result of andrographis paniculata (Family: Acanthaceae), coriandrum sativum (Family:Apiaceae), curcuma longa(Family: Zingiberaceae), ocimum sanctum(Family: Lamiaceae), phyllanthus emblica(Family: Phyllanthaceae) and trigonellafoenum-graecum(Family: Fabaceae) extract as a result of they need been used historically for the treatment of worm infestation. Additional exploring the phytoconstituents gift within the herbs of the polyherbal formulation can aid us within the bioactivity gift.
Various concentration of ethanolic extracts of varied herbs and therefore the polyherbal formulation were subjected for assessment of anthelmintic activity in Pheritima posthuma. Time of dysfunction associated time of death was used as an analysis parameter. helminthic change state (10 mg/ml) was used as a customary drug. Phytochemical take a look at discovered the presence of alkaloids, flavanoids, glycosides, carbohydrates, phenolic compounds and tannins. Concentration dependent anthelmintic result was discovered with the extract. once one hundred mg/ml concentration of ethanolic extracts of the polyherbal formulation was more it showed dysfunction of take a look at worm (earthworm) at eight minutes and death at fifteen minutes. The combination of two plant extracts has shown substantial anthelmintic activity exploitation in vitro model on earthworms which can be attributed to the polyphenols gift within the extract.
