Synthesis, Characterization and antimicrobial Studies of isonicotinoyl 2-chlorobenzaldehyde Hydrazone and The Ni II and Co II complexes

International Journal of Research and Innovation in Applied Science (IJRIAS) | Volume VI, Issue IV, April 2021|ISSN 2454-6194

Synthesis, Characterization and antimicrobial Studies of isonicotinoyl 2-chlorobenzaldehyde Hydrazone and The Ni II and Co II complexes

Idoko, O.,¹ Mamman, S.,² Ukoha, P.O.,³ and Abdullahi, I.^4
1Chemistry Advanced Research Center, Sheda Science and Technology Complex, PMB 186, FCT, Abuja, Nigeria.
²,⁴Department of Chemistry, University of Abuja, FCT, Nigeria
³Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.

Abstract
isonicotinoyl 2-chlorobenzaldehyde hydrazone and the Ni II and Co II complexes were synthesized and characterized via melting point, solubility test, conductivity measurement, magnetic susceptibility, UV visible spectrophotometry, Infrared spectrophotometry and metal analysis using Atomic Absorption Spectrophotometry. The antimicrobial screening was also carried out on the ligand and complexes using some bacteria and fungal strains. The melting point of the complexes are higher than the ligand. The ligand and complexes are insoluble in water, but soluble in dimethyl sulphoxide. The conductivity test showed that the ligand and complexes are non-conductors. The magnetic susceptibility measurement pointed out that the Ni II complex is diamagnetic, while the Ni II complex is paramagnetic. There was coordination via the azomethine nitrogen and carbonyl oxygen. The Ni II complex has a square planar geometry while the Co II complex has an octahedralgeometry. The ligand and complexes has appreciable activities against some of the selected organisms.

Introduction

Hydrazones are related to ketones and aldehydes by the replacement of the carbonyl oxygen with the NNH2 functional group and are characterized by the presence of the triatomic grouping C=NN- and they can be considered as Schiff bases derived from acid hydrazides2. They are formed usually by condensation of hydrazine and ketones or aldehydes. The most important property of hydrazones is their high physiological activity. Extensive studies have revealed that the lone pair on trigonally hybridized nitrogen atom of the azomethine group is responsible for the chemical and biological activity2. It has been reported that metal complexes of hydrazones have diverse applications2. These compounds and their complexes are being synthesized as drugs by many researchers in order to combat diseases with minimal toxicity and maximal effects.

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