In-Vitro Assay to Investigate the Anti-Inflammatory Activity of Hydroalcoholic Leaves Extract of Acacia Auriculiformis A.Cunn. Ex Benth.

International Journal of Research and Scientific Innovation (IJRSI) | Volume VII, Issue IV, April 2020 | ISSN 2321–2705

In-Vitro Assay to Investigate the Anti-Inflammatory Activity of Hydroalcoholic Leaves Extract of Acacia Auriculiformis A.Cunn. Ex Benth.

Vaishnavi Nimbalkar*, Manish Kamble, Jagdish Baheti
Kamla Nehru College of Pharmacy, Butibori, Nagpur (M.S.) India
*Corresponding author

Abstract: Secondary metabolite obtained from medicinal plants are progressively used in the treatment of various diseases as a complementary medicine. When infectious microorganisms such as bacteria, viruses or fungi invade the body, reside in particular tissues and/or circulate in the blood, inflammation occurs and also happen in response to tissue injury, cell death, cancer, ischemia and degeneration. The present study reveals the scientific evidence to the traditional use of Earleaf acacia (Acacia auriculiformis) as anti-inflammatory drug. The HRBC membrane stabilization method has been used to study the invitro anti-inflammatory activity. The result expressed the concentration dependent membrain stabilizing potential.

Keywords: Earleaf acacia, anti-inflammatory, HRBC, stabilization

I. INTRODUCTION

Inflammation is a defensive mechanism of our body to hazardous stimuli such as tissue injury or allergy. It is frequently associated with pain and involves occurrences of some events such as increase of vascular permeability, increase of protein denaturation and membrane alteration. These events usually occurs when infectious microorganisms such as bacteria, viruses or fungi invade the body, circulates in the blood¹ or some times in response to processes such as tissue injury, cell death, cancer, ischemia and degeneration².Pain, redness, warmness and swelling are the primary symptoms of inflammation.  When there is an injury, blood circulation towards the injured tissue increases and this produces redness³. Inflammatory crisis can be controlled and supressed by various medicines. Some of them aresteroids, NSAID’s, and immune suppressant’s. Though, these are associated with many adverse effects, there is need to apply natural anti-inflammatory agents to increase pharmacological response and the lowest degree of unwanted side effects⁴.  Herbal medicines are promoting as alternatives or as complimentary medication for allopathic medicines with no or less adverse effects.  In the present study assessment of in-vitro antiinflamatory activity was studied using Acaccia auriculiformis leaves extract.

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