Management of Early-Onset Non-Exudative (Dry) Age-Related Macular Degeneration Through Ayurvedic Shodhana and Kriyakalpa: A Case Report

Authors

Dr Hemant Kumar Nagar

Shalakya Tantra, National Institute of Ayurveda, Jaipur (India)

Dr Arjun Singh Patidar

Shalakya Tantra, National Institute of Ayurveda, Jaipur (India)

Prof. Gulab Chand Pamnani

Shalakya Tantra, National Institute of Ayurveda, Jaipur (India)

Dr Rajendra Kumar Soni

Shalakya Tantra, National Institute of Ayurveda, Jaipur (India)

Article Information

DOI: 10.47772/IJRISS.2026.100500340

Subject Category: AYURVEDA CASE STUDY

Volume/Issue: 10/5 | Page No: 5158-5165

Publication Timeline

Submitted: 2026-05-07

Accepted: 2026-05-12

Published: 2026-06-01

Abstract

Background: Age-related macular degeneration (ARMD) is a progressive neurodegenerative disease of the retina. While typically a geriatric condition, early-onset ARMD (before age 50) is an emerging clinical concern with limited therapeutic interventions in conventional medicine for the non-exudative (dry) form.
Methods: A 43-year-old male diagnosed with dry ARMD presented with painless, gradual diminution of vision in both eyes. The condition was diagnosed as Pitta Vidagdha Drishti based on Ayurvedic clinical features. Management followed an integrated Ayurvedic protocol comprising Shodhana (systemic purification via Nasya and Matra Basti), Shamana (internal medicine), and Kriyakalpa (targeted ocular therapies including Akshi Tarpana and Anjana).
Results: Post-treatment Optical Coherence Tomography (OCT) demonstrated a significant reduction in drusen count (from 4 to 1 in the left eye) and stabilized retinal thickness. Best Corrected Visual Acuity (BCVA) improved from 6/24 to 6/12 in the left eye.
Conclusion: Ayurvedic management effectively addresses both the functional and structural aspects of early-onset dry ARMD, providing a promising non-invasive strategy for retinal preservation.

Keywords

Early-onset ARMD, Pitta Vidagdha Drishti, Kriyakalpa, Akshi Tarpana, Optical Coherence Tomography.

Downloads

References

1. Bowling B. Kanski's Clinical Ophthalmology: A Systematic Approach. 8th ed. Edinburgh: Elsevier; 2016. Chapter 14, Acquired macular disorders; p. 586-592. [Google Scholar] [Crossref]

2. Gupta SK, Vishwakarma RK, Singh GS. Indian subcontinent prevalence-risk factors of age-related macular degeneration. Acta Ophthalmol. 2009;87(3):262-269. [Google Scholar] [Crossref]

3. Wong WL, Su X, Li X, Cheung CM, Klein R, Cheng CY, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health. 2014;2(2):e106-116. [Google Scholar] [Crossref]

4. Fernandes AR, Baptista PV, Rodrigues LR, Oliveira J, Ramos S, Ponte MN, et al. Exudative versus Nonexudative Age-Related Macular Degeneration: Physiopathology and Treatment Options. Int J Mol Sci. 2022;23(5):2592. [Google Scholar] [Crossref]

5. Hussain RM, Ciulla TA. Emerging vascular endothelial growth factor antagonists for neovascular age-related macular degeneration. Expert Opin Emerg Drugs. 2017;22(3):235-246. [Google Scholar] [Crossref]

6. Shastri AD, editor. Sushruta Samhita of Maharshi Sushruta, Uttara Tantra, Ch. 7, Ver. 12. 1st ed. Varanasi: Chaukhambha Sanskrit Sansthan; 2012. p. 28. [Google Scholar] [Crossref]

7. Upadhyaya Y, editor. Ashtanga Hridayam of Vagbhata, Uttara Sthana, Ch. 13, Ver. 42. Reprint ed. Varanasi: Chaukhambha Prakashan; 2019. p. 521. [Google Scholar] [Crossref]

8. Belamkar SR, et al. Concept of Nasya and its probable action on the Eye: A Review. Journal of Indian System of Medicine. 2017;5(3):195-201. [Google Scholar] [Crossref]

9. Sharma R, Singh H. Basti: The Most Comprehensive Management for All Vata Disorders - A Review. Int J Ayurvedic Med. 2021;12(2):165-171. [Google Scholar] [Crossref]

10. Mao D, Tao B, Sheng S, et al. Causal Effects of Gut Microbiota on Age-Related Macular Degeneration: A Mendelian Randomization Study. Invest Ophthalmol Vis Sci. 2023;64(12):32. doi:10.1167/iovs.64.12.32. [Google Scholar] [Crossref]

11. Janoria KG, Gunda S, Boddu SH, Mitra AK. Novel approaches to retinal drug delivery. Expert Opin Drug Deliv. 2007;4(4):371-388. doi:10.1517/17425247.4.4.371. [Google Scholar] [Crossref]

12. Rathore AS, Gupta S, Kadian J, et al. Critical Review of Anjana: A Potential Ocular Drug Delivery System in Ayurveda. Ayushi Int Interdiscip Res J. 2022;9(5):45-51. [Google Scholar] [Crossref]

13. Kumar S, et al. Rakta Prasadaka properties of Manjisthadi formulations: Impact on peripheral microcirculation and tissue oxygenation. Int J Health Sci Res. 2020;10(1):154-162. [Google Scholar] [Crossref]

14. Jaiswal S, et al. Anti-inflammatory and antioxidant potential of Yogaraja Guggulu in chronic degenerative disorders: A pharmacological review. J Drug Deliv Ther. 2021;11(4-S):145-151. [Google Scholar] [Crossref]

15. Paranjpe P. Chakshushya Rasayana in the era of Digital Eye Strain: A phytochemical study on Triphala and retinal health. Int J Res Ayur Pharm. 2022;13(4):88-93. [Google Scholar] [Crossref]

Metrics

Views & Downloads

Similar Articles