Aftermath of Acute and Chronic Administration of Chloroform Leaf Extract of Vernonia amygdalina on Blood Glucose Levels in Normoglycemic and Streptozotocin-induced Hyperglycemic Mice

This study evaluated the acute and chronic effects of chloroform extract of Vernonia amygdalina (CHEVA) on blood glucose concentration (BGC) in normoglycemic and streptozotocin (STZ)-induced hyperglycemic mice. Sixty male albino mice were randomized into groups (n = 5). Acute (900 mg/kg) and chronic (300 mg/kg) intraperitoneal doses of CHEVA were administered, while tolbutamide served as standard drug. Hyperglycemia was induced using STZ (50 mg/kg IP). Blood glucose levels were measured at defined intervals. Data were analyzed using repeated-measures ANOVA followed by Tukey post hoc test. CHEVA produced no significant change in normoglycemic mice (p > 0.05). However, significant reductions were observed in STZ-induced mice during chronic treatment (p < 0.05). Phytochemical analysis revealed flavonoids, terpenoids, and alkaloids. The findings support the antidiabetic potential of Vernonia amygdalina, possibly via insulin sensitization and glucose uptake enhancement.

Vernonia amygdalina, Diabetes mellitus, Blood glucose, STZ, Phytochemicals

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