Integrative Ayurvedic and Biomedical Management of Polycystic Ovary Syndrome: A Longitudinal N-of-1 Observational Study with Clinical and Reproductive Outcomes

background: Polycystic Ovary Syndrome (PCOS) is a chronic endocrine–metabolic disorder marked by hyperandrogenism, anovulation, and insulin resistance. Integrative approaches combining classical Ayurveda with modern biomedical therapy are frequently used in India, yet systematically documented real-world outcomes remain scarce.

Objective: To document longitudinal menstrual, metabolic, and reproductive outcomes in a woman with PCOS following an integrative Ayurvedic–biomedical therapeutic regimen.

Methods: An N-of-1, eight-month prospective observational study was conducted on a 25-year-old woman with ultrasound-confirmed PCOS. Therapy included metformin and myo-inositol along with classical Ayurvedic formulations targeting Kapha–Vata Dushti, Agnimandya, and Srotorodha. Outcomes included menstrual cyclicity, ultrasound-based ovulation tracking, serial haemoglobin trends, symptomatic changes, and conception status. All biomedical safety parameters (LFT, KFT) were monitored.

Results: Menstrual cycles gradually normalized (from >45 days to 28–32 days). Ovulation was confirmed by follicular ultrasound. Haemoglobin increased from 7.3 g/dL to 10.2 g/dL over the observation period. A spontaneous conception occurred in January 2025. Safety parameters remained within normal limits. Causality cannot be inferred due to concurrent biomedical therapy and absence of hormonal markers.

Conclusion: Integrative care in this single-subject study was associated with improved cycle regularity, ovulatory function, hematological restoration, and conception. Controlled trials with standardized protocols are required to evaluate efficacy and mechanisms.

PCOS, Integrative Medicine, Ayurveda, Ovulation, Infertility, Hemoglobin, N-of-1 Study

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